Dynamics of Helicobacter pylori infection in infants during the first six months of life

Merino, José S.; Araneda, Liliana; Lincoñir-Campos, Paulina; Parra, Cristian; Sáez, Katia; García, Antonio Manuel Rodríguez

doi:10.1016/j.eimce.2018.03.011

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…During the first month of life, prevalence and incidence of the infection were 23.9% and 13%, respectively. These results suggest that there is a high risk of H pylori infection during the first month of life 18 …”

Section: Helicobacter Pylori Acquisitionmentioning

confidence: 66%

Review: Epidemiology of Helicobacter pylori

et al. 2020

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This review summarizes the recent knowledge on the epidemiology of Helicobacter pylori and the potential modes of transmission. In addition to English language publications, the authors have included original full‐text publications from Russia and Latin America published in the original languages. High H pylori prevalence has been reported in Russia, Jordan, Iran, China, and Latin American countries as well as in Arctic populations in Canada. Indigenous inhabitants in the Arctic were found to be infected substantially more frequently than non‐indigenous inhabitants. In Amsterdam, the Netherlands, the ethnic minority groups were at a significantly higher risk of being H pylori seropositive compared to the Dutch population. For the first time, data on the prevalence from Armenia have been published indicating 41.5% H pylori prevalence. Convincing evidence on the decline of H pylori prevalence in Southeast Hungary and Taiwan was published. A study from Chile suggested high infection rates in newborns during the first month after birth. Two meta‐analyses covered the potential correlation between H pylori and periodontal diseases, therefore addressing the potential oro‐oral transmission rates. Periodontal disease was found to be more prevalent in H pylori‐infected subjects. Other studies addressed the potential role of drinking water and food products as well as socioeconomic factors in transmitting the infection. Several studies in Asia addressed annual reinfection rates of H pylori, ranging from 1.5% in China to 3.1% in Korea. Finally, a review was published on the current evidence and future perspective of analysing H pylori in ancient human remains by a metagenomic approach.

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Section: Helicobacter Pylori Acquisitionmentioning

confidence: 66%

Review: Epidemiology of Helicobacter pylori

et al. 2020

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“…Since L. fermentum UCO-979C is a good biofilm-forming bacterium, it may help to protect the gastric epithelium from the colonization of H. pylori [ 21 ]. The prophylactic effect of L. fermentum UCO-979C was already described by Merino et al in an in vivo model [ 25 ], demonstrating that Mongolian gerbils which previously received the probiotic L. fermentum UCO-979C strain showed reduced colonization by H. pylori in the stomach antrum (87% reduction, p = 0.004) and stomach body (77% reduction, p = 0.0476). To the best of our knowledge, the prophylactic activity of the strain L. fermentum UCO-979C against H. pylori has been also previously reported for other lactobacilli [ 52 , 58 ].…”

Section: Discussionmentioning

confidence: 65%

“…Our research group conducted a detailed characterization of the probiotic properties and the anti- H. pylori activity of the Limosilactobacillus fermentum UCO-979C strain, previously known as Lactobacillus fermentum UCO-979C, a lactic acid bacterium isolated from the human stomach [ 21 , 22 ], demonstrating that this strain is capable of tolerating an acidic pH and bile salts, producing hydrogen peroxide, and that it is highly hydrophobic [ 23 , 24 ]. Moreover, it was observed that this strain is able to efficiently adhere to the gastric mucosa, as shown by its in vitro adherence to gastric carcinoma human cells (AGS) and its in vivo adherence to the gastric mucosa in the Mongolian gerbil model [ 25 ]. Furthermore, it was demonstrated that L. fermentum UCO-979C strongly inhibits the adhesion, growth and the urease activity of H. pylori and that it improves resistance against infection by this pathogen, modulating the gastric innate immune response [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved

Parra-Sepúlveda

Sánchez-Alonzo

Olivares-Muñoz

et al. 2022

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Helicobacter pylori is a bacterium associated with various gastrointestinal diseases of high worldwide prevalence. Since probiotics are an emerging alternative to managing infection by this pathogenic bacterium, the present work evaluated, in a randomized double-blind study controlled by a placebo, if consuming Limosilactobacillus fermentum UCO-979C prevents H. pylori infection in humans. Participants consumed either L. fermentum UCO-979C-supplemented gelatin (67 participants) or placebo-supplemented gelatin (64 participants) once a day, five days per week for 12 weeks. H. pylori infection in the participants was controlled before and after the intervention detecting H. pylori antigens in stools. Regarding H. pylori-infected participants before the study, 100% remained infected at the end of the study in the placebo group, while 96.7% of those receiving the probiotic remained infected after the intervention. Most importantly, of the non-infected participants, 34.2% became infected and 65.8% remained non-infected in the placebo group, while 2.7% became infected and 97.3% remained as non-infected individuals in the intervened group. Therefore, consuming the L. fermentum UCO-979C strain significantly reduced H. pylori infection, demonstrating a 92.6% efficacy in avoiding infection by this pathogen in non-infected individuals; thus, this probiotic is an excellent candidate to prevent H. pylori infections in non-infected individuals.

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“…For example, the proportion of seropositive children aged 10-15 years ranged from 6.6 % in New Zealand, 11 % in the UK, 13.4 % in Italy, 16.1 % in Sweden, and up to 17.9 % in the USA. As for developing countries, N. pylori infection is found in Albania in 96 %, India -84 %, China -67 %, Czech Republic -63 %, Mexico -55.3 % of adolescents [2][3][4]11].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Infection in Children

Бораева¹,

Remizov²,

Ревазова³

et al. 2019

Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

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Helicobacter pylori infection is one of the most common chronic human infections, and epidemiological studies indicate a high prevalence of this infection, especially in children. [1, 3, 11]. H. pylori infection varies from 40 to 90 % in the adult population in different regions of the world, in the CIS countries-70-80 %. The prevalence of pyloric Helicobacter in different regions of the world is determined by the level of economic development of the country, and the social level of certain groups of the population within the country. According to domestic and foreign authors, 60-80 % of gastritis cases and 88-100 % of duodenal ulcer diseases are associated with H. pylori infection in childhood [2, 4, 5]. H. pylori is a special pathogenic agent that causes an asymptomatic course in most infected people. However, asymptomatic patients are a risk group in which chronic gastritis, gastric ulcer, duodenal ulcer, extranodal Bcell MALT lymphoma or gastric adenocarcinoma develop over time [6, 7]. A person acquires H.pylori in early childhood, usually after the first year of life. Transmission from mother to child and from child to child is most probable, the risk of acquiring an infection is highly correlated with the infectious status of the mother and siblings, and is also associated with living conditions in overcrowded families [8-10]. The article presents the study results of the clinical picture of upper digestive tract diseases associated with helicobacter pylori in children.

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Dynamics of Helicobacter pylori infection in infants during the first six months of life

Cited by 3 publications

References 13 publications

Review: Epidemiology of Helicobacter pylori

Review: Epidemiology of Helicobacter pylori

Consumption of a Gelatin Supplemented with the Probiotic Strain Limosilactobacillus fermentum UCO-979C Prevents Helicobacter pylori Infection in a Young Adult Population Achieved

Helicobacter Pylori Infection in Children

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