Thrombotic thrombocytopenic purpura-TTP (Moschcowitz's disease) is one of the most severe forms of microangiopathy, which is characterized by intense platelet aggregation, thrombocytopenia consumption, microangiopathic hemolytic anemia, and ischemic damage to various organs. TTP is extremely rare for children and, therefore, it is difficult for clinicians to verify the disease and determine a treatment program. The disease has an aggressive course. When there is no adequate therapy, it can be fatal. The paper provides the analysis of a clinical case of an eleven-year-old girl with thrombotic thrombocytopenic purpura.

Helicobacter pylori infection is one of the most common chronic human infections, and epidemiological studies indicate a high prevalence of this infection, especially in children. [1, 3, 11]. H. pylori infection varies from 40 to 90 % in the adult population in different regions of the world, in the CIS countries-70-80 %. The prevalence of pyloric Helicobacter in different regions of the world is determined by the level of economic development of the country, and the social level of certain groups of the population within the country. According to domestic and foreign authors, 60-80 % of gastritis cases and 88-100 % of duodenal ulcer diseases are associated with H. pylori infection in childhood [2, 4, 5]. H. pylori is a special pathogenic agent that causes an asymptomatic course in most infected people. However, asymptomatic patients are a risk group in which chronic gastritis, gastric ulcer, duodenal ulcer, extranodal Bcell MALT lymphoma or gastric adenocarcinoma develop over time [6, 7]. A person acquires H.pylori in early childhood, usually after the first year of life. Transmission from mother to child and from child to child is most probable, the risk of acquiring an infection is highly correlated with the infectious status of the mother and siblings, and is also associated with living conditions in overcrowded families [8-10]. The article presents the study results of the clinical picture of upper digestive tract diseases associated with helicobacter pylori in children.