Dynamics of human milk nutrient composition of women from singapore with a special focus on lipids

Thakkar, Sagar K.; Giuffrida, Francesca; Cruz‐Hernandez, Cristina; Castro, Carlos Antonio De; Mukherjee, Rajat; Tran, Liên-Anh; Steenhout, Philippe; Lee, Le Ye; Destaillats, Frédéric

doi:10.1002/ajhb.22446

Cited by 114 publications

(108 citation statements)

References 49 publications

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“…Although bST was able to overwhelm sex-biased milk synthesis among multiparous cows, significant sex-bias remained among primiparous cows whose mammary glands had functionally developed for the first time in the context of the fetal sex of the first gestation. The magnitude of sex bias is strongest among first parity rhesus monkeys [25][26] and possibly humans [28][29] and Tamar wallabies [31] in which primiparous females have been disproportionately represented in published studies. The effect of fetal sex may diminish to some extent among multiparous females due to the aggregate effects on mammary gland architecture of sequential gestations of different fetal sexes.…”

Section: Discussionmentioning

confidence: 99%

“…Suckling behavior, however, is not useful for estimating milk energy transfer as verified by experimental use of radio-labeled isotopes in Equus caballus [22]. Direct evidence for sex-biased milk synthesis among nondomesticated species has now been reported in ungulates (Cervus elaphus hispanicus, [23]), rodents (Myodes glareolus [24]), primates (Macaca mulatta [25][26]; Homo sapiens [27][28][29], but see also [30] for exception), and marsupials (Macropus eugenii, [31]). Drawing systematic conclusions from the studies to date, however, is challenging in part because most have been limited by relatively small sample sizes or report milk composition without accounting for milk yield.…”

Section: Introductionmentioning

confidence: 99%

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Holsteins Favor Heifers, Not Bulls: Biased Milk Production Programmed during Pregnancy as a Function of Fetal Sex

Hinde

Carpenter

Clay

et al. 2014

Preprint

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Mammalian females pay high energetic costs for reproduction, the greatest of which is imposed by lactation. The synthesis of milk requires, in part, the mobilization of bodily reserves to nourish developing young. Numerous hypotheses have been advanced to predict how mothers will differentially invest in sons and daughters, however few studies have addressed sexbiased milk synthesis. Here we leverage the dairy cow model to investigate such phenomena. Using 2.39 million lactation records from 1.49 million dairy cows, we demonstrate that the sex of the fetus influences the capacity of the mammary gland to synthesize milk during lactation. Cows favor daughters, producing significantly more milk for daughters than for sons across lactation. Using a sub-sample of this dataset (N = 113,750 subjects) we further demonstrate that the effects of fetal sex interact dynamically across parities, whereby the sex of the fetus being gestated can enhance or diminish the production of milk during an established lactation. Moreover the sex of the fetus gestated on the first parity has persistent consequences for milk synthesis on the subsequent parity. Specifically, gestation of a daughter on the first parity increases milk production by ,445 kg over the first two lactations. Our results identify a dramatic and sustained programming of mammary function by offspring in utero. Nutritional and endocrine conditions in utero are known to have pronounced and long-term effects on progeny, but the ways in which the progeny has sustained physiological effects on the dam have received little attention to date.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Holsteins Favor Heifers, Not Bulls: Biased Milk Production Programmed during Pregnancy as a Function of Fetal Sex

Hinde

Carpenter

Clay

et al. 2014

Preprint

View full text Add to dashboard Cite

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“…Additionally, as our previous work and other studies have observed differences in breast milk composition by infant sex, we also tested for sex interactions. 3,26,27 …”

Section: Introductionmentioning

confidence: 99%

Associations of Maternal Weight Status Before, During, and After Pregnancy with Inflammatory Markers in Breast Milk

Whitaker¹,

Marino²,

Haapala³

et al. 2018

Obesity

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Objective-To examine the associations of maternal weight status before, during, and after pregnancy with breast milk C-Reactive Protein (CRP) and Interleukin-6 (IL-6), two bioactive markers of inflammation, measured at one and three months postpartum.Methods-Participants were 134 exclusively breastfeeding mother-infant dyads taking part in the Mothers and Infants LinKed for Health (MILK) study, who provided breast milk samples. Prepregnancy body mass index (BMI) and gestational weight gain (GWG) were assessed by chart abstraction; postpartum weight loss was measured at the one and three month study visits. Linear regression was used to examine the associations of maternal weight status with repeated measures of breast milk CRP and IL-6 at one and three months, after adjustment for potential confounders.Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms Contact Information for Corresponding Author: Ellen W. Demerath, 1300 S 2 nd Street, Suite 300, Minneapolis, MN 55454, ewd@umn.edu, Telephone: 612-624-8231. Disclosures:No other conflicts of interest were reported.Author Contributions: DAF and EWD conceived the project and were responsible for data collection. KMW ran the statistical analyses and wrote the manuscript. LF and KDS assisted with data collection. AMT conducted all breast milk assays. JLH was responsible for data management. DRJ and EWD assisted with statistical analyses. RM completed the literature review. All authors critically reviewed the manuscript and had final approval of the submitted and published versions. HHS Public AccessAuthor manuscript Obesity (Silver Spring). Author manuscript; available in PMC 2018 April 06. Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptResults-Pre-pregnancy BMI and excessive GWG, but not total GWG or postpartum weight loss, were independently associated with breast milk CRP after adjustment (β=0.49, p<0.001 and β=0.51, p=0.011, respectively). No associations were observed for IL-6.Conclusions-High pre-pregnancy BMI and excessive GWG are associated with elevated levels of breast milk CRP. The consequences of infants receiving varying concentrations of breast milk inflammatory markers are unknown; however, we speculate that there are implications for the intergenerational transmission of disease risk.

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“…All recently published HBM ganglioside data have been generated using high-performance liquid chromatographymass spectrometry (HPLC-MS) techniques [12][13][14][15], given the greater sensitivity and specificity of this technique, whereas earlier data were generated using traditional highperformance thin layer chromatography (HPTLC) methods, which are less sensitive and selective [9,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Lactational changes in concentration and distribution of ganglioside molecular species in human breast milk from Chinese mothers

Liu

MacGibbon

et al. 2015

Lipids

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Gangliosides play a critical role in human brain development and function. Human breast milk (HBM) is an important dietary source of gangliosides for the growing infant. In this study, ganglioside concentrations were measured in the breast milk from a cross-sectional sample of Chinese mothers over an 8-month lactation period. The average total ganglioside concentration increased from 13.1 mg/l during the first month to 20.9 mg/l by 8 months of lactation. The average concentration during the typically solely breast-feeding period of 1‒6 months was 18.9 mg/l. This is the first study to report the relative distribution of the individual ganglioside molecular species through lactation for any population group. The ganglioside molecular species are made up of different fatty acid moieties that influence the physical properties of these gangliosides, and hence affect their function. The GM(3) molecular species containing long-chain acyl fatty acids had the most prominent changes, increasing in both concentration and relative distribution. The equivalent long-chain acyl fatty acid GD(3) molecular species typically decreased in concentration and relative distribution. The lactational trends for both concentration and relative distribution for the very long-chain acyl fatty acid molecular species were more varied. The major GM(3) and GD(3) molecular species during lactation were d40:1 and d42:1, respectively. An understanding of ganglioside molecular species distribution in HBM is essential for accurate application of mass spectrometry methods for ganglioside quantification.

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Dynamics of human milk nutrient composition of women from singapore with a special focus on lipids

Abstract: Collectively, the current observations affirm that HM secretion, especially the lipid composition, is a very dynamic and personalized biological process.

Cited by 114 publications

References 49 publications

Holsteins Favor Heifers, Not Bulls: Biased Milk Production Programmed during Pregnancy as a Function of Fetal Sex

Holsteins Favor Heifers, Not Bulls: Biased Milk Production Programmed during Pregnancy as a Function of Fetal Sex

Associations of Maternal Weight Status Before, During, and After Pregnancy with Inflammatory Markers in Breast Milk

Lactational changes in concentration and distribution of ganglioside molecular species in human breast milk from Chinese mothers

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