Dynamics of induced glass transition of porous and nonporous silica nanoparticles

Sharma, Dipti; Farah, K.

doi:10.1007/s10973-017-6689-2

Cited by 2 publications

(2 citation statements)

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“…We observed six distinct peaks for drug at 6.0 • , 8.0 • , 10.0 • , 12.0 • , 21.0 • and 31.0 o . Furthermore, in pure silica nanoparticles we observed distinct peaks which are possible indication of ordered 2D hexagonal mesoporous structure and two broad diffusion peaks recorded around 10 o and 23 o gives indication of their amorphous nature as mentioned in the literature [45,51,64].…”

Section: X-ray Powder Diffractionsupporting

confidence: 67%

“…If the drug in the pores is in a non-crystalline state, no melting point depression can be detected [65,66]. As shown in Figure 6, the DSC curve of MSN exhibited an endothermic phase transition at 53 °C which corresponds to its glass transition temperature (Tg) where the amorphous sample went through a transition to a rubbery state as reported in the literature for porous silica nanoparticles [64].…”

Section: Differential Scanning Calorimetrysupporting

confidence: 55%

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In-Vitro and In-Vivo Evaluation of Velpatasvir- Loaded Mesoporous Silica Scaffolds. A Prospective Carrier for Drug Bioavailability Enhancement

et al. 2020

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The limited aqueous solubility of many active pharmaceutical ingredients (APIs) is responsible for their poor performance and low drug levels in blood and at target sites. Various approaches have been adopted to tackle this issue. Most recently, mesoporous silica nanoparticles (MSN) have gained attention of pharmaceutical scientists for bio-imaging, bio-sensing, gene delivery, drug solubility enhancement, and controlled and targeted drug release. Here, we have successfully incorporated the poorly water soluble antiviral drug velpatasvir (VLP) in MSN. These spherical particles were 186 nm in diameter with polydispersity index of 0.244. Blank MSN have specific surface area and pore diameter of 602.5 ± 0.7 m2/g and 5.9 nm, respectively, which reduced after successful incorporation of drug. Drug was in amorphous form in synthesized VLP-loaded silica particles (VLP-MSN) with no significant interaction with carrier. Pure VLP showed poor dissolution with progressive increment in pH of dissolution media which could limit its availability in systemic circulation after oral administration. After VLP loading in silica carriers, drug released rapidly over a wide range of pH values, i.e., 1.2 to 6.8, thus indicating an improvement in the solubility profile of VLP. These particles were biocompatible, with an LD50 of 448 µg/mL, and in-vivo pharmacokinetic results demonstrated that VLP-MSN significantly enhanced the bioavailability as compared to pure drug. The above results clearly demonstrate satisfactory in-vitro performance, biocompatibility, non-toxicity and in-vivo bioavailability enhancement with VLP-MSN.

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Section: X-ray Powder Diffractionsupporting

confidence: 67%