Dynamics of Irig in Treatment of Heart Transplant Rejections

Self Cite

Background. Cardiovascular diseases are very common among solid organ recipients. They are associated with worsening transplant outcomes. Arterial vascular wall elasticity is an important prognostic indicator and a risk marker for cardiovascular events. Noninvasive measurement of common carotid artery (CCA) elasticity may be useful in assessing cardiovascular risk in solid organ recipients.Objective: To conduct a comparative analysis of indicators of CCA elasticity in solid organ recipients and to study their relationship with factors that potentially have a negative impact on the risk of adverse events.Materials and methods. The study included 154 patients aged 10 to 75 years, including heart (n = 77), liver (n = 9), and kidney (n = 35) recipients, as well as 33 patients with end-stage heart failure waitlisted for heart transplantation (HT). In all participants, carotid artery ultrasound was performed, pulse wave velocity was measured, and CCA elasticity was calculated.Results. CCA elasticity was found to be strongly inversely correlated with age, body mass index, systolic blood pressure, renal tubular filtration rate, CCA intima media thickness, and aortic pulse wave velocity. In heart recipients, CCA elasticity was significantly lower than in liver and kidney recipients (p = 0,002) and it inversely correlated with the length of time elapsed after transplantation, which is probably associated with cardiac denervation.Conclusion. CCA elasticity calculated via noninvasive ultrasound reflects the degree of adverse effects of pathological factors on the main arteries in solid organ recipients.

Changes in common carotid artery elasticity in solid organ recipients

Shevchenko,

Tyunyaeva,

Lysenko

et al. 2023

Self Cite

Functional indicators of peripheral arterial stiffness in solid organ recipients (literature review)

Lysenko,

Tyunyaeva,

Shevchenko

2024

Increased arterial stiffness is an important preclinical indicator of cardiovascular dysfunction, arterial hypertension and target organ injury. This condition increases the risk of long-term adverse events. Solid organ recipients face multiple risk factors for cardiovascular complications due to transplant rejection, lifelong medication use and adaptive features of the transplanted organ. The review presents an analysis of the results of studies on the main functional indicators of peripheral arterial stiffness, as well as the potential effect of immunosuppressive therapy on indicators of vascular stiffness in solid organ recipients.

Predictive value of non-invasive common carotid artery elasticity in heart recipients

Shevchenko,

Tyunyaeva,

Lysenko

et al. 2024

Objective: to study the predictive value of the local noninvasive elasticity index of the common carotid artery (CCA) wall in heart transplant recipients. Materials and methods. The study included 101 heart recipients. All study subjects underwent ultrasound examination of carotid arteries with assessment of the damping function of arteries and measurement of local and regional indicators of elastic properties of the CCA. The vascular wall elasticity index (iCOMPL) of the CCA was calculated according to the formula using the CCA diameters in systole and diastole and measurements of systolic and diastolic blood pressure. All-cause death, heart retransplantation, and clinically significant heart transplant coronary artery disease were evaluated as combined endpoints (adverse outcomes).Results. In heart recipients without morphological and immunohistochemical signs of heart graft rejection, detection of relatively low iCOMPL of CCA is a predictor of earlier development of adverse events (p = 0.03). Conclusion. iCOMPL of the CCA is a noninvasive and easily reproducible predictor of adverse out- comes in the long-term period after heart transplantation and can be used in clinical practice for the purpose of risk stratification in heart recipients.