Dynamics of Oxidative Stress in Helicobacter pylori-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer

Цуканов, В. В.; Смирнова, О. В.; Kasparov, Edward Vilyamovich; Sinyakov, Alexander Alexandrovich; Vasyutin, A. V.; Tonkikh, Yu.L.; Cherepnin, Mikhail Alexandrovich

doi:10.3390/diagnostics12051203

Cited by 6 publications

(5 citation statements)

References 58 publications

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“…Current evidence indicates a pivotal role of oxidative stress in the onset of H. pylori infection, underscoring the importance of identifying antioxidant elements with protective effects from a public health standpoint 23 . In a Mediterranean cohort of Spanish graduates, a robust inverse association was identified between the OBS and mortality rates related to all causes, cardiovascular diseases (CVD), and cancer 24 .…”

Section: Discussionmentioning

confidence: 99%

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

Xiong,

Xu,

Zhu

et al. 2024

Int. J. Med. Sci.

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Background: Limited research has examined the association between Oxidative Balance Score (OBS) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This study investigates the correlation between OBS and H. pylori infection and their impacts on all-cause mortality within a cohort of individuals, considering both infected and uninfected individuals. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, comprising 4,532 participants, were analyzed. Logistic regression analyses assessed the relationship between H. pylori infection and relevant covariates. Cox regression and restricted cubic spline analysis evaluated the association between total OBS, lifestyle OBS, dietary OBS, and all-cause mortality in H. pylori -positive and -negative individuals. Results: Restricted cubic spline modeling revealed a linear relationship between total OBS and all-cause mortality, particularly in H. pylori -negative patients. Total OBS, dietary OBS, and lifestyle OBS inversely correlated with H. pylori infection, even after adjusting for confounders. Higher dietary OBS was associated with decreased mortality risk exclusively in H. pylori -positive individuals, while lifestyle OBS was associated with mortality only in H. pylori -negative individuals. These findings underscore the complex relationships between OBS, H. pylori infection, and mortality, stressing the importance of infection status in assessing oxidative balance's impact on health. Conclusion: In this sample, higher OBS was associated with lower H. pylori infection risks. Dietary OBS correlated significantly with all-cause mortality in H. pylori -positive individuals, while lifestyle OBS was notably associated with mortality in H. pylori -negative participants. Further research is necessary to elucidate the underlying mechanisms and clinical implications of these findings.

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Section: Discussionmentioning

confidence: 99%

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

Xiong,

Xu,

Zhu

et al. 2024

Int. J. Med. Sci.

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“…168,169 In line with conception, higher MDA abundance has been determined among individuals with H. pylori-infected gastric mucosa, which dramatically decreased after H. pylori elimination, and showed no significant difference compared to control group. 170 Similarly, higher levels of MDA have been detected in H. pylori-induced chronic gastritis and gastric cancer patients, 171,172 revealing a noteworthy positive correlation between H. pylori induced MDA and the risk of gastric cancer. 162,163,171 4-hydroxy-2,3-nonenal (4HNE), a byproduct of lipid peroxidation, is widely recognized as a key "second messenger of free radicals" and growth-regulating factor in carcinogenesis.…”

Section: Lipid Damagementioning

confidence: 99%

Reactive oxygen species and gastric carcinogenesis: The complex interaction between Helicobacter pylori and host

Wu,

Chen,

Chen

et al. 2023

Helicobacter

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Helicobacter pylori (H. pylori) is a highly successful human pathogen that colonizes stomach in around 50% of the global population. The colonization of bacterium induces an inflammatory response and a substantial rise in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), mostly derived from host neutrophils and gastric epithelial cells, which play a crucial role in combating bacterial infections. However, H. pylori has developed various strategies to quench the deleterious effects of ROS, including the production of antioxidant enzymes, antioxidant proteins as well as blocking the generation of oxidants. The host's inability to eliminate H. pylori infection results in persistent ROS production. Notably, excessive ROS can disrupt the intracellular signal transduction and biological processes of the host, incurring chronic inflammation and cellular damage, such as DNA damage, lipid peroxidation, and protein oxidation. Markedly, the sustained inflammatory response and oxidative stress during H. pylori infection are major risk factor for gastric carcinogenesis. In this context, we summarize the literature on H. pylori infection‐induced ROS production, the strategies used by H. pylori to counteract the host response, and subsequent host damage and gastric carcinogenesis.

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“…H. pylori can also produce numerous factors with stabilization effects. For example, catalase and superoxide dismutase (SOD) implicates in scavenging reactive oxygen species (ROS) and toxic long‐chain fatty acids 19 . Other enzymes include arginases and phospholipase 13 .…”

Section: Virulence Factors and Pathogenesis Of H Pylorimentioning

confidence: 99%

“…implicates in scavenging reactive oxygen species (ROS) and toxic long-chain fatty acids. 19 Other enzymes include arginases and phospholipase. 13 Arginase is a part of the urea cycle.…”

mentioning

confidence: 99%

Helicobacter pylori antigens as immunomodulators of immune system

Marzhoseyni,

Mousavi,

Ghotloo

2024

Helicobacter

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Helicobacter pylori (H. pylori) is one of the most prevalent human pathogens and the leading cause of chronic infection in almost half of the population in the world (~59%). The bacterium is a major leading cause of chronic gastritis, gastric and duodenal ulcers, and two type of malignancies, gastric adenocarcinoma and mucosa‐associated lymphoid tissue (MALT) lymphoma. Despite the immune responses mounted by the host, the bacteria are not cleared from the body resulting in a chronic infection accompanied by a chronic inflammation. Herein, a review of the literature discussing H. pylori antigens modulating the immune responses is presented. The mechanisms that are involved in the modulation of innate immune response, include modulation of recognition by pattern recognition receptors (PRRs) such as modulation of recognition by toll like receptors (TLR)4 and TLR5, modulation of phagocytic function, and modulation of phagocytic killing mediated by reactive oxygen species (ROS) and nitric oxide (NO). On the other hands, H. pylori modulates acquired immune response by the induction of tolerogenic dendritic cells (DCs), modulation of apoptosis, induction of regulatory T cells, modulation of T helper (Th)1 response, and modulation of Th17 response.

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Dynamics of Oxidative Stress in Helicobacter pylori-Positive Patients with Atrophic Body Gastritis and Various Stages of Gastric Cancer

Cited by 6 publications

References 58 publications

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

Reactive oxygen species and gastric carcinogenesis: The complex interaction between Helicobacter pylori and host

Helicobacter pylori antigens as immunomodulators of immune system

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