2018
DOI: 10.3390/cancers10070221
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Dynamics of p14ARF and Focal Adhesion Kinase-Mediated Autophagy in Cancer

Abstract: It has been widely shown that the focal adhesion kinase (FAK) is involved in nearly every aspect of cancer, from invasion to metastasis to epithelial–mesenchymal transition and maintenance of cancer stem cells. FAK has been shown to interact with p14ARF (alternative reading frame)—a well-established tumor suppressor—and functions in the negative regulation of cancer through both p53-dependent and -independent pathways. Interestingly, both FAK and ARF (human and mouse counterpart) proteins, as well as p53, are … Show more

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Cited by 9 publications
(6 citation statements)
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“…As an important non-selective degradation machinery, autophagy is found to regulate the focal adhesion disassembly, β1 integrin membrane recycling, and the acquisition of mesenchymal markers, all of which are crucial for cell migration. While the precise positive or negative role for autophagy in cell migration varies depending on the cellular context (Tuloup-Minguez et al, 2013; Liu et al, 2017; Fontana and Vivo, 2018). To our knowledge, we firstly revealed the involvement of autophagy in the migration of keratinocyte under HG treatment.…”
Section: Discussionmentioning
confidence: 99%
“…As an important non-selective degradation machinery, autophagy is found to regulate the focal adhesion disassembly, β1 integrin membrane recycling, and the acquisition of mesenchymal markers, all of which are crucial for cell migration. While the precise positive or negative role for autophagy in cell migration varies depending on the cellular context (Tuloup-Minguez et al, 2013; Liu et al, 2017; Fontana and Vivo, 2018). To our knowledge, we firstly revealed the involvement of autophagy in the migration of keratinocyte under HG treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Although for several years ARF was considered to be dysfunctional when over-expressed in cancer tissues, surprisingly, ARF silencing was shown to limit the progression of Myc-driven lymphomas in mouse xenograft models [123]. In this study, Humbey and co-authors proposed for the first time that ARF can promote tumor progression through its ability to induce autophagy [60,124,125,126,127]. Autophagy is a lysosome-mediated process of self-digestion occurring during periods of nutrient deprivation.…”
Section: Arf Has Pro-oncogenic Functionsmentioning
confidence: 99%
“…Target proteins and organelles are enveloped by the autophagosome, a double-membrane vesicle, that fuses with the lysosome leading to the degradation of its contents. The released amino acids are thus recycled for the synthesis of essential proteins [124]. ARF silencing in Myc-driven lymphoma cells impaired autophagy and decreased the ability of these cells to form tumors in vivo.…”
Section: Arf Has Pro-oncogenic Functionsmentioning
confidence: 99%
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“…So far it has been shown how p14ARF exerts a broader role in cell protection as, in addition to oncogenic stimuli, it can respond to a variety of different stresses arising in both pathological and physiological conditions, such as development, differentiation, aging and autophagy [ 6 , 7 , 8 , 9 ]. In particular, although since its discovery ARF was linked to anti-oncogenic functions, several experimental observations suggested for the first time that ARF can promote tumour progression [ 3 ].…”
Section: Introductionmentioning
confidence: 99%