Dynamics of Prostate Cancer Rate and Mortality in Ukraine: Current State of Affairs

Kobilnyk, Yu. S.; Mytsyk, Yulian; Borzhievsky, Andriy; Vorobets, D. Z.; Matskevych, V. M.

doi:10.25040/ntsh2020.02.06

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…A meta-analysis by Yang L et al revealed that cancer is an independent risk factor for mortality in COVID-19 patients [8]. Moreover, the presence of malignancy has been identified as one of the key contributing factors impacting the mortality pattern in patients with ischemic heart disease, hypertension, and diabetes mellitus [9]. Additionally, anemia, which is commonly present in patients with bone marrow cancer, serves as risk determinant of severe COVID-19 outcomes [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Multiple Myeloma Patient with Secondary Liver and Tongue Involvement, Complicated by COVID-19-Induced ARDS: An Autopsy Case Report and Literature Review

Matskevych,

Ilnytska,

Lenchuk

et al. 2024

Galician med. j.

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Background. Liver involvement secondary to multiple myeloma is a rare and uncommon radiologic finding. Such extraosseous secondary lesions as well as tongue involvement require pathohistological confirmation to prevent misdiagnosis. Clinical and laboratory diagnostics are challenging in patients with COVID-19 and underlying multiple myeloma and its secondary lesions, leading to difficulties in treatment and outcomes. Case Report. A 64-year-old male patient, not vaccinated against COVID-19, with a history of multiple myeloma presented with symptoms of headache, fatigue, dyspnea, cough, and fever. The patient’s medical history was intricate, involving cholecystectomy and a diagnosis of multiple myeloma, which was subsequently treated with chemotherapy and radiation therapy. Additionally, uncommon liver and tongue involvement secondary to multiple myeloma was found. Upon admission, the patient’s peripheral oxygen saturation was 90%, accompanied by increasing shortness of breath and a respiratory rate of 26 breaths per minute. A positive COVID-19 test was recorded. A lung computed tomography revealed bilateral multifocal areas of ground-glass opacity and consolidation, encompassing the entire pulmonary regions, corresponding to CO-RADS 6. The patient was admitted to the intensive care unit. Despite initiating oxygen support and symptomatic therapy, the patient’s death occurred. Autopsy confirmed the development of severe acute respiratory distress syndrome and bilateral hemorrhagic pneumonia, with multiple myeloma as a contributing factor. Conclusions. This case report highlighted the rare occurrence of secondary liver involvement in multiple myeloma, characterized by nodules with distinct imaging features. It underscored the importance of identifying coexisting lesions, such as tongue involvement, and the diagnostic challenges they pose. Additionally, the case emphasized the need for comprehensive clinical assessment in patients with concurrent COVID-19 and underlying multiple myeloma, as it may lead to the development of acute respiratory distress syndrome.

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Section: Introductionmentioning

confidence: 99%

Multiple Myeloma Patient with Secondary Liver and Tongue Involvement, Complicated by COVID-19-Induced ARDS: An Autopsy Case Report and Literature Review

Matskevych,

Ilnytska,

Lenchuk

et al. 2024

Galician med. j.

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“…Prostate cancer (PC) is a malignant neoplasm that develops from the epithelium of the prostate. This disease is one of the most common cancers among men, as it ranked 4th after cancer of the trachea, bronchi, lungs, colon and rectum and stomach cancer in 2019 [1,2]. This type of cancer is most common for men over the age of 50 [2,3].…”

Section: Introductionmentioning

confidence: 99%

Medical and Social Substantiation of the Problem of Quality of Life of Patients With Prostate Cancer

Zub

Толстанов²

2022

Proc Shevchenko Sci Soc Med Sci

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Introduction. Prostate cancer (PC) is one of the most common cancers among men over 50. Nowadays in Ukraine, the number of new cases of PC tends to increase according to statistics. Objectives. The aim of the study is to identify the main problems in the life quality of patients with PC (C61) to optimize medical care for them. Methods. The main aspects of the quality of life of PC patients are studied by means of EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. Results. In Ukraine, as of the pre-war period (November 2021 – February 2022), the quality of life of patients with PC amounted to 52.31 on a 100-point scale. The worst indicators within the functional scale QLQ-C30 belonged to the subscale “Role functioning” (65.44). According to the QLQ-C30 symptoms scale, the highest score among the complaints of Ukrainian patients is fatigue (48.58). Given the results of our research on the QLQ-PR25 symptom scale, patients with PC were the most worried about “Urinary symptoms”, with a score of 38.54 out of 100. According to the functional scale QLQ-PR25, the worst indicators were for “Sexual activity”, which is equal to 32.22 points on a 100-point scale. Conclusions. It is important to create socio-psychological support for patients with PC and their families, which will include the development and implementation of standardized psychological care at all stages of diagnosis, treatment and rehabilitation.

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Possibilities of Radiological Scan Methods With Post-Processing Image Reconstruction in the Assessment of Atherosclerotic Plaques of the Carotid Arteries

Segin

2024

Scientific and practical journal

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The aim. To establish the informativeness of the methods of computed tomography angiography, ultrasound diagnostics and magnetic resonance arteriography without contrast in patients with atherosclerosis of carotid arteries. Materials and methods. During July 2022 - July 2024, 82 male patients were examined on the basis of the Neurological Pathology Diagnostic Center of the KNP "Regional Clinical Hospital of the Ivano-Frankivsk Regional Council". Forty-six of them were included in the study group with clinical signs of atherosclerotic lesions of the carotid arteries. Thirty-six patients with asymptomatic course of the carotid arteries atherosclerosis were chosen as the control group. Patients of both groups were aged 51-79 years, and were homogeneous in terms of concomitant diseases, duration of smoking and lipidogram results. Exclusion criteria from both cohorts were: the presence of arrhythmia, radiation treatment of oncological processes in the projection of the head and neck, diagnosed Alzheimer's disease or Fara's disease, lack of written informed consent to participate in the study, impaired legal capacity of the person, when the written consent cannot be considered truly conscious. CTA was performed using a 160-slice computer tomograph Aquilion Prime Toshiba Scanner TSX-302A (Toshiba) with SUREPlaque software to analyze atherosclerotic plaques and vessels in the Carotid CTA fast scanning mode. MRI of the head and neck with non-contrast MR-arteriography was performed using a 1.5 Tesla Phillips Achieva device using blood flow imaging sequences: s3DI MC (three-dimensional time of flight MR-angiography). Ultrasound of the carotid arteries was performed using the Esaote MyLab9eXP device using B-mode, Doppler mapping and elastography. Atherosclerotic plaques were assessed according to the new imaging-based classification - Carotid Plaque-RADS from 2024. The results. According to the classification of Carotid Plaque-RADS, the following results were obtained according to visualization by ultrasound and CT methods: a combination of plaques of categories from Plaque-RADS 2 to Plaque-RADS 4, considering the types of each category, was detected in patients of both groups. There was no significant difference between the groups in the assessment of the structure of the atherosclerotic plaque (p=0.616). For the study group, the detection of the higher percentage of the stenotic lumen of the vessel was statistically different (median - 68.5% (interquartile range 9.75%)) compared to the control group (median - 60.0% (interquartile range 7.5%)) (p =0.048). A comparison of the degree of stenosis by ultrasound and CTA methods was carried out, where a direct correlation of very high strength according to the Chaddock scale was established (r=0.934 (confidence interval: 0.881 – 0.964), p˂0.001). Atherosclerotic lesions were characterized by indirect signs on MRI, namely: wall filling defects, which most likely correspond to plaques, increased bends of main arteries. Conclusions. Ultrasound diagnostics and reconstructive post-processing capabilities of computed tomography were practically equivalent in assessing the degree of stenosis with high correlation strength (r=0.934) and highly informative images of atherosclerotic masses of carotid arteries, while non-contrast magnetic resonance arteriography allowed to suspect atherosclerotic lesions as an area of a filling defect without detailed tissue structures.

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Dynamics of Prostate Cancer Rate and Mortality in Ukraine: Current State of Affairs

Cited by 5 publications

References 7 publications

Multiple Myeloma Patient with Secondary Liver and Tongue Involvement, Complicated by COVID-19-Induced ARDS: An Autopsy Case Report and Literature Review

Multiple Myeloma Patient with Secondary Liver and Tongue Involvement, Complicated by COVID-19-Induced ARDS: An Autopsy Case Report and Literature Review

Medical and Social Substantiation of the Problem of Quality of Life of Patients With Prostate Cancer

Possibilities of Radiological Scan Methods With Post-Processing Image Reconstruction in the Assessment of Atherosclerotic Plaques of the Carotid Arteries

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