Dynamics of pseudorabies virus infections in vaccinated pig populations: A review

Stegeman, Arjan; Jong, M.C.M. de; Nes, A. van; Bouma, A.

doi:10.1080/01652176.1997.9694754

Cited by 12 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…including only a few parameters, the model greatly facilitates analysis of data on infectious diseases (see also (5)) and clarifies various major characteristics of population dynamics in epidemics. Its outcomes have been found to be quantitatively comparable with data from experiments and observations (7,15,25,40).…”

Section: Stochastic Sir Modelsupporting

confidence: 79%

“…When there are a few herds with a high seroprevalence, regional eradication of PRV can be achieved by culling these herds. The other 'positive' samples incidently found with the gE-ELISA might have been the result of minor outbreaks (see (25,40)) or might have been false positive results (41). This means that if no new instances of (finishing) herds with a high seroprevalence are detected after selectively culling the herds with a high seroprevalence, then it can be assumed that all single reactors in a herd are the result of false positive test results, and vaccination can be stopped.…”

Section: Prospects For Prv Eradicationmentioning

confidence: 99%

“…This implied that eradicating PRV from sow herds by vaccination is feasible, although questions remained about the impact of reactivation on transmission and whether the transmission ratio among sows with more contacts, such as group-housed sows, would be higher, resulting in reproduction ratios significantly higher than 1. PRV transmission in and the growth performance of finishing pigs vaccinated either once or twice were estimated and compared (40). The study was performed with a randomized block design; all pigs in a compartment were vaccinated either once or twice.…”

Section: Applications Of the Model To Prvmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Nes

2001

Veterinary Quarterly

Self Cite

View full text Add to dashboard Cite

Section: Stochastic Sir Modelsupporting

confidence: 79%

Section: Prospects For Prv Eradicationmentioning

confidence: 99%

Section: Applications Of the Model To Prvmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Nes

2001

Veterinary Quarterly

Self Cite

View full text Add to dashboard Cite

“…In 2001, Germany was listed as Aujeszky's disease-free. Eradication efforts included selective culling of PRV-positive herds, widespread vaccination programs with marker viruses such as gE-null vaccine strains, restricted importation of swine, and improved herd management practices to isolate swine from potential reservoirs of infection such as wild boar (295,381,417). In 2003, countries with documented cases of PRV (in alphabetical order) included Belarus, Brazil, Cuba, France, Hungary, Italy, Mexico, Panama, Poland, Portugal, Romania, Russia, Slovakia, Slovenia, Taiwan, and Ukraine.…”

Section: Worldwide Distribution Of Pseudorabiesmentioning

confidence: 99%

Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine

Pomeranz

Reynolds

Hengartner

2005

Microbiol Mol Biol Rev

724

657

View full text Add to dashboard Cite

Pseudorabies virus (PRV) is a herpesvirus of swine, a member of the Alphaherpesvirinae subfamily, and the etiological agent of Aujeszky's disease. This review describes the contributions of PRV research to herpesvirus biology, neurobiology, and viral pathogenesis by focusing on (i) the molecular biology of PRV, (ii) model systems to study PRV pathogenesis and neurovirulence, (iii) PRV transsynaptic tracing of neuronal circuits, and (iv) veterinary aspects of pseudorabies disease. The structure of the enveloped infectious particle, the content of the viral DNA genome, and a step-by-step overview of the viral replication cycle are presented. PRV infection is initiated by binding to cellular receptors to allow penetration into the cell. After reaching the nucleus, the viral genome directs a regulated gene expression cascade that culminates with viral DNA replication and production of new virion constituents. Finally, progeny virions self-assemble and exit the host cells. Animal models and neuronal culture systems developed for the study of PRV pathogenesis and neurovirulence are discussed. PRV serves as a self-perpetuating transsynaptic tracer of neuronal circuitry, and we detail the original studies of PRV circuitry mapping, the biology underlying this application, and the development of the next generation of tracer viruses. The basic veterinary aspects of pseudorabies management and disease in swine are discussed. PRV infection progresses from acute infection of the respiratory epithelium to latent infection in the peripheral nervous system. Sporadic reactivation from latency can transmit PRV to new hosts. The successful management of PRV disease has relied on vaccination, prevention, and testing

show abstract

“…The vaccination scheme used in the Dutch eradication programme for pseudorabies virus was developed with knowledge about the transmission obtained from transmission experiments combined with mathematical modelling [9].…”

Section: Introductionmentioning

confidence: 99%

Transmission of Actinobacillus pleuropneumoniae in pigs is characterized by variation in infectivity

Velthuis

Jong

Stockhofe³

et al. 2002

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYTen transmission trials with Actinobacillus pleuropneumoniae were carried out. The observed transmission was highly variable, which was surprising since the design of the trials was very similar. We investigated whether the variable transmission could be explained by variation in infectivity of A. pleuropneumoniae infected pigs. We looked for measurable characteristics, which could be indicative for infectious pigs or for the level of infectivity. The characteristic that appeared to be most indicative for a pig being infectious was an A. pleuropneumoniae positive tonsil at necropsy. The characteristic that was correlated to the level of infectivity was the number of A. pleuropneumoniae colonies isolated from the nasal swab, i.e. the probability for an infectious pig to infect a susceptible pig was tenfold higher on days where at least ten colonies were isolated. In this study it is shown that it is possible to measure the bacterial transmission of A. pleuropneumoniae under controlled circumstances if variation in infectivity is taken into account.

show abstract

Dynamics of pseudorabies virus infections in vaccinated pig populations: A review

Cited by 12 publications

References 20 publications

Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Epidemiology: Mathematical modelling of pseudorabies virus (Syn. Aujeszky's disease virus) outbreaks aids eradication programmes: A review

Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine

Transmission of Actinobacillus pleuropneumoniae in pigs is characterized by variation in infectivity

Contact Info

Product

Resources

About