Dynamics of the progesterone and cholesterol concentrations within the bovine corpus luteum cavity

Rizzo, Annalisa; Stefani, Anna Lisa; Piccinno, M.; Roncetti, M.; D'Onghia, G.; Sciorsci, Raffaele Luigi

doi:10.1016/j.rvsc.2016.08.006

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Our data therefore strongly suggests that cholesterol synthesis (de novo and from exogenous sources) plays a major role in sustaining luteal progesterone levels. This proposition is supported by the study of Mares et al [ 14 , 18 ] in which they showed that luteal cholesterol content was elevated throughout most of the bovine CL lifespan (until day 15).…”

Section: Discussionmentioning

confidence: 56%

Genomic profiling of bovine corpus luteum maturation

et al. 2018

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To unveil novel global changes associated with corpus luteum (CL) maturation, we analyzed transcriptome data for the bovine CL on days 4 and 11, representing the developing vs. mature gland. Our analyses revealed 681 differentially expressed genes (363 and 318 on day 4 and 11, respectively), with ≥2 fold change and FDR of <5%. Different gene ontology (GO) categories were represented prominently in transcriptome data at these stages (e.g. days 4: cell cycle, chromosome, DNA metabolic process and replication and on day 11: immune response; lipid metabolic process and complement activation). Based on bioinformatic analyses, select genes expression in day 4 and 11 CL was validated with quantitative real-time PCR. Cell specific expression was also determined in enriched luteal endothelial and steroidogenic cells. Genes related to the angiogenic process such as NOS3, which maintains dilated vessels and MMP9, matrix degrading enzyme, were higher on day 4. Importantly, our data suggests day 11 CL acquire mechanisms to prevent blood vessel sprouting and promote their maturation by expressing NOTCH4 and JAG1, greatly enriched in luteal endothelial cells. Another endothelial specific gene, CD300LG, was identified here in the CL for the first time. CD300LG is an adhesion molecule enabling lymphocyte migration, its higher levels at mid cycle are expected to support the transmigration of immune cells into the CL at this stage. Together with steroidogenic genes, most of the genes regulating de-novo cholesterol biosynthetic pathway (e.g HMGCS, HMGCR) and cholesterol uptake from plasma (LDLR, APOD and APOE) were upregulated in the mature CL. These findings provide new insight of the processes involved in CL maturation including blood vessel growth and stabilization, leucocyte transmigration as well as progesterone synthesis as the CL matures.

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Section: Discussionmentioning

confidence: 56%

Genomic profiling of bovine corpus luteum maturation

et al. 2018

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“…El CL produce hormona pregnenolona (figura 5.4) y posteriormente P4 a partir de COL (Aréchiga- Flores et al, 2019). Si la fertilización ocurre, el CL permanece y la vaca queda gestante (Rizzo et al, 2016). Sin embargo, si la fertilización no ocurre o falla, la prostaglandina F2α (PGF2α) ocasiona luteólisis, y se reactiva la foliculogénesis (Mezera et al, 2019).…”

Section: Figura 54 Esteroidogénesis Ovárica (Fase Lútea)unclassified

Sustentabilidad, Turismo y Educación TII

Gutiérrez¹

2020

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©ECORFAN-México, S.C.Ninguna parte de este escrito amparado por la Ley Federal de Derechos de Autor, podrá ser reproducida, transmitida o utilizada en cualquier forma o medio, ya sea gráfico, electrónico o mecánico, incluyendo, pero sin limitarse a lo siguiente: Citas en artículos y comentarios bibliográficos de compilación de datos periodísticos radiofónicos o electrónicos. Para los efectos de los artículos 13, 162,163 fracción I, 164 fracción I, 168, 169,209 fracción III y demás relativos de la Ley Federal de Derechos de Autor. Violaciones: Ser obligado al procesamiento bajo ley de copyright mexicana. El uso de nombres descriptivos generales, de nombres registrados, de marcas registradas, en esta publicación no implican, uniformemente en ausencia de una declaración específica, que tales nombres son exentos del protector relevante en leyes y regulaciones de México y por lo tanto libre para el uso general de la comunidad científica internacional. HSTE es parte de los medios de ECORFAN (www.ecorfan.org

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“…El CL produce hormona pregnenolona (figura 5.4) y posteriormente P4 a partir de COL (Aréchiga-Flores et al, 2019). Si la fertilización ocurre, el CL permanece y la vaca queda gestante (Rizzo et al, 2016). Sin embargo, si la fertilización no ocurre o falla, la prostaglandina F2α (PGF2α) ocasiona luteólisis, y se reactiva la foliculogénesis (Mezera et al, 2019).…”

Section: Figura 54 Esteroidogénesis Ovárica (Fase Lútea)unclassified

Fisiología del período de transición, posparto y retorno al estro en vacas lecheras: desafíos para la producción sustentable

García-Casillas¹

2020

Sustentabilidad, Turismo Y Educación TII

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Dynamics of the progesterone and cholesterol concentrations within the bovine corpus luteum cavity

Cited by 7 publications

References 7 publications

Genomic profiling of bovine corpus luteum maturation

Genomic profiling of bovine corpus luteum maturation

Sustentabilidad, Turismo y Educación TII

Fisiología del período de transición, posparto y retorno al estro en vacas lecheras: desafíos para la producción sustentable

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