1968
DOI: 10.1085/jgp.52.1.29
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Dynamics of Transcapillary Fluid Exchange

Abstract: Fluid balance at the capillary level has been simulated with an analogue computer program, based on experimental data on regional differences in capillary permeability, surface areas, and hydrostatic pressures. The program takes into account fluid and protein fluxes into and out of the interstitial space. Solutions are obtained for tissue hydrostatic pressure, tissue fluid osmotic pressure, interstitial space volume, and lymph flow. Simulation of a variety of physiological experiments and clinical disease stat… Show more

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Cited by 120 publications
(31 citation statements)
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“…This interpretation is also supported by the finding that an increase in mucosal water content (representing interstitial edema) did not become detectable below the threshold venous pressure. These results strongly suggest that the chief compensatory factor is not elevated tissue fluid pressure, and hence that most likely it is decreased tissue fluid colloid osmotic pressure, as concluded by others (29,30).…”
Section: Discussionsupporting
confidence: 78%
“…This interpretation is also supported by the finding that an increase in mucosal water content (representing interstitial edema) did not become detectable below the threshold venous pressure. These results strongly suggest that the chief compensatory factor is not elevated tissue fluid pressure, and hence that most likely it is decreased tissue fluid colloid osmotic pressure, as concluded by others (29,30).…”
Section: Discussionsupporting
confidence: 78%
“…Similarly, in vivo studies that examine the kinetics of signaling and transporter mobilization show that the two processes occur within 10 min of insulin binding (31,32). However, even before receptor binding and signaling, insulin must diffuse through the gel-like matrix of skeletal muscle interstitium to distribute itself among its receptors (33). To our knowledge, this is the first in vivo study to examine the kinetics of insulin arriving at its receptor sites once it has entered the interstitial matrix.…”
Section: Discussionmentioning
confidence: 82%
“…The initial values of variables used for this simulation are listed in Table 1. The protein concentration of lymph fluid in the control period was used for the interstitial fluid (WIEDERHIELM, 1968;AUKLAND and NICOLAYSEN, 1981), and the initial value of interstitial fluid volume was determined by a study on another 7 rats using the 51Cr-EDTA dilution method. Mean circulatory filling pressure (MCFP) was used for the initial value of Poas.…”
Section: Simulationmentioning
confidence: 99%