Dynamischer Scheimpflug-Analyzer (Corvis ST) zur Bestimmung kornealer biomechanischer Parameter

Herber, Robert; Terai, Naim; Pillunat, Karin R; Raiskup, Frederik; Pillunat, Lutz E; Spörl, E.

doi:10.1007/s00347-018-0716-y

Cited by 19 publications

(13 citation statements)

References 46 publications

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“…More recently, Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) was introduced which measures the corneal deformation process in response to an air impulse and allows in vivo imaging of corneal biomechanical responses. [13–17] It has been suggested to measure the changes in the elastic properties of the cornea, such as how stiff or soft the cornea is, and has been reported to be more useful in detecting the true biomechanical property of the cornea than ORA. [18]…”

Section: Introductionmentioning

confidence: 99%

Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

2019

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Purpose To investigate the relationship between corneal deflection amplitude and visual field progression rate in patients with primary open-angle glaucoma (POAG). Methods This study included 113 eyes of 65 patients with POAG followed for an average of 4.81 ± 1.24 years. Evaluation of visual field progression rate was performed using mean deviation of standard automated perimetry. Corneal deflection amplitude was measured using Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany). Linear mixed models were performed to determine the relationship between corneal deflection amplitude, intraocular pressure (IOP), and visual field progression rate. Results Mean age was 56.36 ± 14.58 years. Baseline average mean deviation was -8.20 ± 9.12 dB and mean treated IOP was 14.38 ± 3.08 mmHg. Average deflection amplitude was 0.90 ± 0.13 mm. In both univariate and multivariate analysis, IOP ( P = 0.028 and P < 0.001, respectively) and deflection amplitude ( P = 0.034 and P < 0.001, respectively) significantly affected visual field progression rate. Eyes with high IOP and greater deflection amplitude showed faster progression rate. Conclusions Corneal deflection amplitude was significantly related with glaucoma progression. Eyes with greater corneal deflection amplitude showed faster visual field progression rate in patients with POAG.

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Section: Introductionmentioning

confidence: 99%

Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

2019

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“…B. die optische Kohärenzelastografie (OCE) [13], Brillouin-Spektroskopie [14] oder die Phase-Decorrelation-OCT (OCT: optische Kohärenztomografie) [15] liefern im Gegensatz zu den Non-Kontakt-Tonometriemethoden wie dem Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Deutschland) oder dem ORA (Reichert, Depew, NY, USA) ortsaufgelöste Information und bilden so die Realität besser ab. Der Vorteil der Non-Kontakt-Tonometrieverfahren liegt in einer einfachen Messung und der schnellen Akquisitionszeit [16]. In dieser Arbeit soll der gegenwärtige Stand der Erforschung der Brillouin-Spektroskopie für die ophthalmologische Klinik dargestellt und bewertet werden.…”

Section: Resultsunclassified

“…In contrast to noncontact tonometry methods such as the Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) or the ORA (Reichert, Depew, NY, USA), the clinically acceptable corneal elasticity examination methods proposed in recent years, such as optical coherence elastography (OCE) [13], Brillouin spectroscopy [14], or phase decorrelation optical coherence tomography [15], provide space-resolved information and thus better reflect reality. The advantage of noncontact tonometry methods lies in the ease of measurement and the rapid acquisition time [16]. This paper aims to present and evaluate the current state of research on Brillouin spectroscopy in ophthalmology.…”

Section: Brillouin Spectroscopy In Ophthalmologymentioning

confidence: 99%

Gegenwärtiger Stand der Brillouin-Spektroskopie in der Ophthalmologie

Seiler

Geerling

2023

Klin Monbl Augenheilkd

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DEUTSCH Hintergrund: Die korneale Biomechanik hat einen erheblichen Einfluss auf das Ergebnis von hornhautchirurgischen Eingriffen, wie astigmatische Keratotomien und kann Ursache für Komplikationen, wie z. B. einer iatrogenen Keratektasie sein. Bisherige Ansätze die korneale Biomechanik und Spannungsverteilung in vivo zu bestimmen, um Komplikationen zu vermeiden und Operationsergebnisse besser vorherzusagen waren nicht erfolgreich. Ziel der Arbeit: In dieser Übersichtsarbeit soll die Funktionsweise der Brillouin-Spektroskopie erläutert und der gegenwärtige wissenschaftliche Stand der Technik für den Einsatz in der Ophthalmologie dargelegt werden. Methoden: Pubmed-Recherche relevanter experimenteller und klinischer Arbeiten, sowie eigene Erfahrungen mit der Brillouin-Spektroskopie. Ergebnisse: Die Brillouin-Spektroskopie kann verschiedene biomechanische Moduli von okulären Geweben mit einer hohen räumlichen Auflösung bestimmen. Mit den derzeit verfügbaren Geräten können an der Hornhaut fokale Schwächungen (Keratokonus) ebenso wie Versteifungen (nach Crosslinking) identifiziert werden. Auch die biomechanischen Eigenschaften der Linse können gemessen werden. Die Anisotropie und Hydratation der Kornea, ebenso wie die Winkel-Abhängigkeit des Laserstrahls während der Brillouin-Messung erschweren jedoch die Interpretation der gemessenen Daten erheblich. Eine klare Überlegenheit in der Früherkennung von Keratektasien gegenüber der kornealen Tomographie konnte bisher noch nicht gezeigt werden. Schlussfolgerung: Die Brillouin-Spektroskopie ist eine neue Technik zur biomechanischen in vivo-Charakterisierung von okulären Geweben, welche die bisherige diagnostische Lücke schliessen kann. Publizierte Ergebnisse sind vielsprechend, bis zum Einsatz im klinischen Alltag sind jedoch Verbesserungen der Messtechnik, insbesondere hinsichtlich der kornealen Anisotropie erforderlich. ENGLISH Background: Information about corneal biomechanics is crucial for achieving satisfactory outcomes after surgical corneal interventions, e. g. for astigmatic keratotomies, but also to identify corneas that are at risk for postoperative complications such as corneal ectasia. Hitherto, approaches to characterize corneal biomechanics in an in vivo setting have yielded only minor success, demonstrating the unmet medical need for a diagnostic technique to measure ocular biomechanics. Objective: This review shall explain the mechanism of Brillouin spectroscopy and summarize the current scientific knowledge for ocular tissue. Methods: Pubmed research of relevant experimental and clinical publications, as well as reporting of own experience using Brillouin spectroscopy. Results: Brillouin spectroscopy can measure different biomechanical moduli with a high spatial resolution. Currently available devices are able to detect focal corneal weakening, e.g. in keratoconus as well as stiffening after corneal crosslinking. Also, the mechanical properties of the crystalline can be measured. Corneal anisotropy and hydration, together with the dependence on the angle of the incident laser-beam in Brillouin spectroscopy are challenges in the precise interpretation of measured data. A clear advantage in the detection of subclinical keratoconus compared to corneal tomography, however, has not been shown yet. Conclusion: Brillouin spectroscopy is a technique to characterize biomechanical properties of ocular tissue in vivo. Published results confirm ex vivo data of ocular biomechanics, however, further improvements in the acquisition and interpretation of measured data are required until this technique can be used in clinically viable setting.

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“…In addition, corneal tomographic maps can only detect corneal morphological changes, which have certain limitations for the diagnosis of subclinical or forme fruste keratoconus (Herber et al, 2018). In recent years, the development of corneal biomechanical measurement techniques such as Corvis ST and ORA grow rapidly, which can help us to understand the dynamic characteristics of cornea (Herber et al, 2019).…”

Section: Medical Examinationmentioning

confidence: 99%

Comprehensive management of post‐LASIK ectasia: From prevention to treatment

Zhao

Yin

et al. 2023

Acta Ophthalmologica

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Post‐laser in situ keratomileusis (post‐LASIK) ectasia (PLE) is one of the most serious complications after refractive surgery, mainly manifested as progressive thinning and trembling thinning of the cornea, accompanied by increased myopia and astigmatism. The mechanisms behind mainly include genetic risk factors and external environmental factors such as eye rubbing and cornea surgery. In order to achieve the goal of reducing the incidence of ectasia, preoperative screening strategies need to be continuously improved, through the collection and assessment of genetic and environmental risk factors. Although previous preoperative screening methods did not have a uniform standard, the emergence of artificial intelligence (AI) can help us process a large amount of information and make rational use of the data. By using high‐fidelity finite element modelling, differences in preoperative and postoperative strain distributions can be observed, which can predict the risk of postoperative ectasia. In this review, we describe the incidence, aetiology, prevention and treatment of PLE for the purpose of comprehensive management. In terms of treatment, corneal collagen cross‐linking has been widely used to treat progressive keratoconus and other ectasia disease, either as a preventive measure during surgery or as a therapeutic modality after surgery to prevent progression of corneal dilation. Although the standard Dresden protocol has been identified as the gold standard treatment for corneal dilatation, a series of refinements, investigations and long‐term studies have been conducted in recent years. Thus, understanding the factors involved in delaying the onset and slowing progression of cornea ectasia will be key to reducing the incidence worldwide.

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Dynamischer Scheimpflug-Analyzer (Corvis ST) zur Bestimmung kornealer biomechanischer Parameter

Abstract: The Corvis ST allows a reliable characterization of the tissue structure and consistency of the cornea.

Cited by 19 publications

References 46 publications

Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

Gegenwärtiger Stand der Brillouin-Spektroskopie in der Ophthalmologie

Comprehensive management of post‐LASIK ectasia: From prevention to treatment

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