Dynein Family Classification

Diamant, Aristides G.; Carter, Andrew P.

doi:10.1007/978-3-642-16712-6_765

Cited by 2 publications

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“…Unlike cytoplasmic dyneins which walk on microtubules while carrying cargos, axonemal dyneins are anchored firmly on the doublet microtubules (Goodenough & Heuser, 1982; Bui et al , 2008, 2009). The ODA complex is composed of two or three heavy chains (HCs) depending on the species (Diamant & Carter, 2013), two intermediate chains (ICs) and numerous light chains (LCs). For example, human cilia have two‐headed ODA (DNAH5 and DNAH9) while ODA of Tetrahymena contains three heavy chains (Dyh3, Dyh4, and Dyh5).…”

Section: Introductionmentioning

confidence: 99%

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM

et al. 2021

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Cilia are thin microtubule‐based protrusions of eukaryotic cells. The swimming of ciliated protists and sperm cells is propelled by the beating of cilia. Cilia propagate the flow of mucus in the trachea and protect the human body from viral infections. The main force generators of ciliary beating are the outer dynein arms (ODAs) which attach to the doublet microtubules. The bending of cilia is driven by the ODAs' conformational changes caused by ATP hydrolysis. Here, we report the native ODA complex structure attaching to the doublet microtubule by cryo‐electron microscopy. The structure reveals how the ODA complex is attached to the doublet microtubule via the docking complex in its native state. Combined with coarse‐grained molecular dynamic simulations, we present a model of how the attachment of the ODA to the doublet microtubule induces remodeling and activation of the ODA complex.

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Section: Introductionmentioning

confidence: 99%

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM

et al. 2021

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Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM

Kubo

Yang

Black

et al. 2020

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Cilia are thin microtubule-based protrusions of eukaryotic cells, beating at high frequency to propel the cell in sperms or clear mucus in the respiratory tract. The ciliary beating is driven by the outer arm dynein arms (ODAs) which anchor on the doublet microtubules. Here, we report the ODA complex structure from the native doublet microtubules by cryo-electron microscopy. Our structure reveals how the ODA complex is attached to the doublet microtubule via the docking complex in its native state. Combined with molecular dynamics simulations, we present a model of how the attachment of the ODA complex to the doublet microtubule induces rearrangements and activation mechanisms within the ODA complex.

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Dynein Family Classification

Cited by 2 publications

References 0 publications

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM

Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM

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