Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish

Chen, Lianguo; Guo, Yongyong; Hu, Chen-Yan; Lam, Patrick T.I.; Lam, James C.W.; Zhou, Bingsheng

doi:10.1016/j.envpol.2017.11.074

Cited by 150 publications

(85 citation statements)

References 43 publications

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“…Because hormonal activity was still present in ex vivo tissue, it is possible that the observed difference between male and female samples could be attributed to differences in endocrine levels. In fact, there have been conclusions drawn between speci c genes and sex hormones in previous studies conducted in rodents and zebra sh [47,48]. One gene, CAV1, that was signi cantly downregulated in this study in female samples exposed to 20 nm AgNPs, has been linked previously to estrogen levels in rats [49,50].…”

Section: Discussionsupporting

confidence: 47%

Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability

Khare

Gokulan

Williams

et al. 2020

Preprint

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Background: Consumer products manufactured with antimicrobial silver nanoparticles (AgNPs) may affect the gastrointestinal (GI) system. The human GI-tract is complex and there are physiological and anatomical differences between human and animal models that limit comparisons between species. Additionally, induction of overt toxicity in animal and in vitro models by AgNP exposure can require doses that are well above what is feasible from environmental exposure or from the use of consumer products. This suggests that a practical assessment of potential AgNP effects on the human GI-tract may require tools that allow for the examination of subtle changes in inflammatory markers and indicators of epithelial perturbation. Methods: We utilize fresh tissue excised from the GI-tract of human male and female subjects to evaluate the effects of AgNPs on the GI-system. The purpose of this study was to perform an assessment on the ability of the ex vivo model to evaluate changes in levels of pro-/anti-inflammatory cytokines/chemokines and mRNA expression of intestinal permeability related genes induced by AgNPs in ileal tissues. Results: The ex vivo model preserved the structural and biological functions of the in-situ organ. Analysis of cytokine expression data indicated that intestinal tissue of male and female subjects responded differently to AgNP treatment, with male samples showing significantly elevated Granulocyte-macrophage colony-stimulating factor (GM-CSF) after treatment with 10-nm and 20-nm AgNPs for 2 hours and significantly elevated RANTES after treatment with 20-nm AgNPs for 24 hours. In contrast, tissues of female patients showed no significant effects of AgNP treatment at 2-hours and significantly decreased RANTES (20 nm), TNF-α (10 nm), and IFN-g (10 nm) at 24-hours. Smaller size AgNPs (10 nm) perturbed more permeability-related genes in samples of male subjects (38 up-regulated, 18 down-regulated), than samples of female subjects (23 up-regulated, 15 down-regulated). In contrast, exposure to 20-nm AgNPs resulted in upregulation of a greater number of genes in female-derived samples (36 genes) than in male-derived samples (8 genes). Conclusion: Results of this study suggest that the ex vivo tissue model deserves further evaluation as a tool to assess the impacts of nanomaterials and other xenobiotic compounds on human intestinal mucosa.

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Section: Discussionsupporting

confidence: 47%

Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability

Khare

Gokulan

Williams

et al. 2020

Preprint

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“…Dietary exposure to BPA also modified the gut microbiota in zebrafish [30,32]. In a study conducted by Liu et al (2016) [32], the authors concluded that exposure to BPA resulted in an increase of the phylum CKC4 in both sexes probably connected to changes in the host lipid metabolism (increased triglycerides in the muscle).…”

Section: Bpa Exposure Induced Significant Decrease Inmentioning

confidence: 99%

“…Exposure to BPA and BPA analogs in animal models such as rodents, zebrafish, rabbits, and dogs can affect the gut microbiota and have an impact on the development of metabolic diseases. Some studies have reported that there is a sexual dysmorphic effect [6,[29][30][31][32][33].…”

Section: Bpa and Analogsmentioning

confidence: 99%

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Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

et al. 2020

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Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.

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“…The dysbiosis of gut microbiota induced by the combined exposure (3 months, chronic toxicity) of TiO 2 NPs (10 nm) at a dose of 100 µg mL ‐1 along with Bisphenol A (BPA) (20 µg mL ‐1 ) severely compromised neurotransmission, epithelial permeability, inflammation, and oxidative stress ( Hyphomicrobium ) and body weight changes ( Bacteroides genus) induced by BPA (bisphenol A) in a sex and concentration‐dependent manner in adult zebrafish. Both nano‐TiO 2 and BPA (bisphenol A) shifted the gut composition of the microbiome community and interacted antagonistically at lower concentrations of BPA (2 µg mL ‐1 ), but synergistically at higher levels of BPA (20 µg mL ‐1 ) …”

Section: Enms Induced Perturbations Of Gut Microbiotamentioning

confidence: 99%

Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges

Ahmad

Wang

2019

Adv Funct Materials

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Nanoscale matter has unique attributes that potentiate their widespread application from biomedicine, engineering, food, cosmetics, sensing, to energy. Due to the rapid industrialization of engineered nanomaterials (ENMs) as a result of increasing consumer interests, more ENMs will be released into the environment, greatly increasing the probability of their contact with humans. Once these ENMs enter the human body or an ecosystem, they may initiate various biochemical responses in unprecedented ways, thus raising important concerns in regard to their effects on human health and the ecosystem. Here, the shifts in the intricate metabolic pathways instigated by ENMs are highlighted and those altered metabolic changes are extrapolated for the elucidation of environmental health and risk assessment. Furthermore, the toxico-metabolomics knowledge of ENMs provides the opportunity to design novel nanomedicine with high efficacies by capitalizing on their abilities to rewire metabolic networks for the treatment of diseases.

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Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish

Cited by 150 publications

References 43 publications

Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability

Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability

Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges

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