Dyslipidemia in adult offspring induced by high fat diet rats at perinatal period.

Abstract

Studies have shown that hormonal, metabolic and nutritional disorders during the early phase of development and/or in the gestation may lead to transitory or permanent structural and functional changes of several organs of the offspring. Our aim was to investigate the impact of high fat diet during the gestation and lactation on biochemical parameters in the offspring of rats. High fat diet was given from day 1 of gestation until weaning of puppies. The biochemical evaluation was performed at 30, 60 and 90 days after birth from High Fat Diet dams (HFDD, n= 6) or Normal Diet dams (NDD, n= 6). Animals from HFDD group presented hyperglycemia starting from day 30 (119 ± 1.6 vs 94.03 ± 2 mg/dl, p<0.05) and LDL (45 ± 7 vs 23 ± 4 mg/dl, p<0.05). In the day 60 OHFD showed difference at TAG ( 61 ± 3 vs 51 ± 1 mg/dl, p<0.05), TC ( 98 ± 5 vs 75 ± 2 mg/dl, p<0.05), VLDL ( 13 ± 0.69 vs 10 ± 0.2 mg/dl, p<0.05) and decrease HDL (42 ± 3 vs 61.42 ± 4 mg/dl, p<0.05). These findings suggest that high fat diet during pregnancy and lactation leads dyslipidemia in adult offspring rats.Support: CNPq, Fapitec and CAPES