Dyslipidemia in Patients with Kidney Disease

Thobani, Aneesha; Jacobson, Terry A.

doi:10.1016/j.ccl.2021.04.008

Cited by 24 publications

(16 citation statements)

References 59 publications

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“…This discrepancy in prevalence in these studies can be attributed to differences in study populations and extent of urbanization between the cities. The prevalence of dyslipidemia among individuals with uncontrolled hypertension and CKD is high and is associated with signi cant risk of morbidity, mortality from CVD and rapid progression of CKD to ESRD and adverse renal outcomes (45,46) (47). The prevalence of dyslipidemia among patients with uncontrolled hypertension was 60.0%; previous studies reported a prevalence range of 45.5%-67.8% across the CKD stage I to CKD stage IV respectively(48,49).…”

Section: Discussionmentioning

confidence: 96%

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

Katatwire

Meremo

2022

Preprint

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Background The prevalence of uncontrolled hypertension has been increasing globally including Sub-Saharan Africa (SSA) accelerating the burden of chronic kidney disease (CKD), cardiovascular diseases (CVD) and non-communicable diseases (NCDs). Methods A cross-sectional study was conducted among adult patients with early-stage CKD attending the medical outpatient department (MOPD) clinics of two tertiary hospitals in Dodoma between November 2020 to March 2021. Descriptive and inferential statistics were performed using SPSS software version 26 and multivariable logistic regression analysis was used to identify variables associated with uncontrolled hypertension. Results A total of 352 patients were enrolled; 64 (18.2%) were in CKD stage 2 and 288 (81.8%) in CKD stage 3, median age was 54 (47–59) years, 182 (51.7%) were males, the prevalence of hypertension was 58.5% and the prevalence of uncontrolled hypertension was 58.3%. For patients with uncontrolled hypertension, the median SBP was 146 (142–150) mmHg, the median DBP was 86(82–90) mmHg, the median BMI was 26.1 (24.0-27.5) kg/m2, the median waist circumference was 97(90–104) cm, the median eGFR of 48 (43–55) mil/min/1.73m2. Among patients with uncontrolled hypertension; 88.3% patients had CKD stage 3, 80.0% patients reported non-adherence to antihypertensives, 76.7% patients had overweight/ obesity, 72.5% patients reported current alcohol use, 60.0% patients had dyslipidemia, 43.3% patients reported current smoking, 36.7% patients had significant proteinuria and 26.7% patients had diabetes mellitus. Variables with higher odds for uncontrolled hypertension were; age ≥ 50 years (OR = 5.17, 95% CI 2.37–13.33, P = 0.001), alcohol use (OR = 11.21, 95% CI 3.83–32.84, P = 0.001), Overweight/obesity (OR = 6.28, 95% CI 2.54–15.53, P = 0.001), non-adherence to antihypertensives (OR = 10.19, 95% CI 4.22–24.61, P = 0.001) and CKD stage 3 (OR = 3.52, 95% CI 1.32–9.42, P = 0.012). Conclusion Uncontrolled hypertension is highly prevalent among patients with early-stage CKD in our settings and it’s associated with age, current alcohol use, overweight/obesity and non-adherence to antihypertensives.

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Section: Discussionmentioning

confidence: 96%

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

Katatwire

Meremo

2022

Preprint

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“…The copyright holder for this preprint this version posted June 28, 2022. ; https://doi.org/10.1101/2022.06.22.22276767 doi: medRxiv preprint Dyslipidemia (DLD), defined as abnormally imbalance amounts of lipids, has a multifaceted but strong contribution to CKD development [2], mortality [1] [2], progression to more severe stages and end-stage renal disease [3], and cardiovascular disease [3]. Lipids are absorbed from the intestines and used for a plethora of functions: energy, steroid production, bile formation, etc.…”

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

Differential Impact of Dyslipidemia on Chronic Kidney Disease between Men and Women

Dalal

2022

Preprint

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Dyslipidemia (DLD), defined as an imbalance of lipids in the blood, is proven to have a strong association with chronic kidney disease (CKD). CKD is more frequent in women than men, although men are more likely to progress to severe stages. Whether sex differences drive the effect of DLD on CKD severity remains unclear. In this study, the relationship between biological sex and CKD severity was investigated by parsing the public electronic health records of 491 CKD patients in Abu Dhabi. Sex-specific relative risks (RRs) were calculated using a history of DLD as a risk factor for severe CKD (stages 3 - 5). The RR was 2.98 (95% CI: 1.78 - 4.18) in women and 2.86 (95 CI%: 2.02 - 3.70) in men. Smoking was identified as a confounding variable because it has a higher incidence in men and a known negative impact on CKD. Thus, we validated the findings in a subsetted group excluding any patient with a history of smoking: the RR was 2.96 (95% CI: 1.76 - 4.16) in women and 2.61 (95% CI: 1.57 - 3.65) in men. These results indicate that, among CKD patients, women with DLD are more likely to progress to severe stages of CKD than men with DLD. The excess risk may be explained by notably higher rates of obesity in women and the idea that women have poorer adherence to DLD medications, although this is newly discovered evidence. Future studies are needed to investigate mechanisms behind this observed disparity.

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“…Obesity has been reported to be associated with the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and CKD in addition to dyslipidemia (8,9). Dyslipidemia, defined as having elevated levels of triglyceride (TG), total cholesterol, and low-density lipoprotein-cholesterol (LDL-C) or low levels of high-density lipoprotein-cholesterol (HDL-C), is an important risk factor for CVD and CKD (10,11). In individuals with dyslipidemia, it has been found that higher TG/HDL-C could increase the risk of CVD by affecting the vessel wall and causing insulin resistance (12).…”

Section: Introductionmentioning

confidence: 99%

Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study

et al. 2022

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Globally, obesity is a major health problem and can markedly increase the risk of various diseases, including type 2 diabetes mellitus, hypertension (HTN), dyslipidemia, and chronic kidney disease (CKD). The association of obesity-related parameters, such as lipid parameters and their ratio, with CKD in clinical settings is not well understood. This study aimed to investigate the association of obesity-related parameters with CKD in the middle-aged and elderly population in Taiwan. This cross-sectional, community-based study recruited 400 participants (141 males and 259 females) aged 50 years or over from a community health promotion project at the Linkou Chang Gung Memorial Hospital (Guishan District, Taoyuan City) in 2014. Each participant completed a questionnaire including personal information and medical history during a face-to-face interview. Laboratory data were obtained from blood and urine sampling. The data were analyzed using t-test, chi-square test, Pearson's correlation test, multivariate logistic regression, and receiver operating characteristic (ROC) analysis. A total of 81 participants were identified as having CKD [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 or urine albumin/creatinine ratio ≥30 mg/g], and their mean triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio was 3.37 ± 2.72. The mean TG/HDL-C ratio of the 319 participants without CKD was 2.35 ± 1.66. After adjusting for age, TG/HDL-C was significantly positively correlated with blood pressure, body mass index, waist circumference, and fasting plasma glucose but not low-density lipoprotein cholesterol. There was a negative correlation between TG/HDL-C and eGFR. Multiple logistic regression model analysis showed that TG/HDL-C was still significantly associated with CKD (OR: 1.17, 95% CI: 1.01–1.36, p = 0.04) after adjusting for multiple covariates. The cut-off point of TG/HDL-C as a predictor of CKD was 2.54 with an area under the ROC curve of 0.61 (95% CI: 0.53–0.68). There was a significant positive correlation between TG/HDL-C and several cardiovascular disease risk factors, including obesity indices. The TG/HDL-C ratio was significantly associated with the risk of CKD and demonstrated predictive ability for CKD in the middle-aged and elderly population. Further studies on its application in clinical settings are warranted.

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Dyslipidemia in Patients with Kidney Disease

Cited by 24 publications

References 59 publications

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

Differential Impact of Dyslipidemia on Chronic Kidney Disease between Men and Women

Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study

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