Dysphagia in Adult Japanese Is Not Equivalent to the Grade of Endoscopic Reflux Esophagitis

Yamaguchi, Kuniko; Kuroki, Tsukasa; Takashima, T; Inoue, Norie; Sakata, Hiroyuki; Tsunada, Seiji; Shiraishi, Ryosuke; Mannen, Kotaro; Fujise, Takehiro; Nakayama, Masayuki; Shimoda, Ryo; Iwakiri, Ryuichi; Fujimoto, Kazuma

doi:10.2169/internalmedicine.46.0301

Cited by 3 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An investigation of the relationship between RE endoscopic findings and GERD symptoms also demonstrated that about 60% of RE relapsed cases had developed no GERD symptoms at the time of RE relapse. Several reports to date have also indicated that RE endoscopic findings were not accompanied by GERD symptoms (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), and this trend was often found in elderly (28). It has also been reported that the percentage of severe RE is higher in the elderly than in juveniles, whereas the frequency of severe heartburn in patients with severe RE is lower in the elderly (27,36).…”

Section: Discussionmentioning

confidence: 91%

Safety and Efficacy of Long-Term Maintenance Therapy with Oral Dose of Rabeprazole 10 mg Once Daily in Japanese Patients with Reflux Esophagitis

Fujimoto

Hongo

Group³

2011

Intern. Med.

Self Cite

View full text Add to dashboard Cite

Objective The aim of this prospective clinical study was to evaluate the efficacy and safety of long-term proton pump inhibitor (PPI) treatment for two years in Japanese patients with reflux esophagitis (RE). Methods The efficacy and safety of two-year (104-week) treatment with rabeprazole (RPZ) 10 mg were studied in patients confirmed to have been cured of RE by PPI and who required long-term maintenance therapy with PPI. We performed serial endoscopy, checked gastroesophageal reflux disease (GERD) symptoms, adverse events, laboratory values and serum gastrin. We also monitored gastric mucosal histology, atrophy and polyps. Results The endoscopic non-relapse rate for RE was 87.3% for the 104-week period. GERD symptoms improved based on the fact that the mean change from baseline in GERD symptom score after treatment was a negative value. Treatment was safe; and atrophy was found to have developed in virtually no cases. A few new benign fundic gland or hyperplastic polyps developed throughout the study, but no ECL carcinoids were found to have developed. Serum gastrin levels tended to increase up to 24 weeks, but there were no subsequent changes thereafter up to 104 weeks. Conclusion The results confirmed oral RPZ 10 mg to be effective for maintenance therapy in Japanese patients with RE. Although effects on the gastric mucosa were not ruled out, long-term use of RPZ was confirmed to be safe overall.

show abstract

Section: Discussionmentioning

confidence: 91%

Safety and Efficacy of Long-Term Maintenance Therapy with Oral Dose of Rabeprazole 10 mg Once Daily in Japanese Patients with Reflux Esophagitis

Fujimoto

Hongo

Group³

2011

Intern. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, we evaluated endoscopy-positive patients who did not complain of symptoms by brief questions by nursing staffs, as in our previous studies [8, 18], and who had not been given medication for gastrointestinal disease. Precise and structured questionnaires for reflux symptoms are useful for diagnosis of gastroesophageal reflux disease, and heartburn is a major and specific symptom that is associated with abnormal manometric and pH results [19–25].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical symptoms might vary between countries and races [4, 5], and several studies from Japan have indicated a relationship between symptoms and reflux esophagitis [6–17]. Our coworkers have previously indicated that clinical symptoms detected by short questions before endoscopic examination were not always equivalent to grading of reflux esophagitis, especially regarding dysphagia, in a cross-sectional study of 8031 subjects [8, 18]. The present study aimed to assess limitation of brief asking of symptoms before endoscopic examination by nursing staffs, and to assess clinical characteristics of patients reflux esophagitis without any symptoms by this process.…”

Section: Introductionmentioning

confidence: 99%

Brief Questioning by Nursing Staffs before Endoscopic Examination May Not Always Pick Up Clinical Symptoms of Endoscopic Reflux Esophagitis

Takashima

Yamaguchi

Hara

et al. 2010

J. Clin. Biochem. Nutr.

Self Cite

View full text Add to dashboard Cite

The clinical features of patients reflux esophagitis without any symptoms have not been clearly demonstrated. This study evaluated the clinical features of patients with endoscopy-positive reflux esophagitis, who did not complain of symptoms, as detected by brief questioning by nursing staffs. Eight thousand and thirty-one patients not taking medication for gastrointestinal disease, were briefly asked about the presence of heartburn, dysphagia, odynophagia and acid regurgitation by nursing staffs before endoscopy for assessment of esophagitis utilizing the Los Angeles Classification. Endoscopically, 1199 (14.9%) patients were classified as positive for reflux esophagitis. The endoscope positive subjects who complain heartburn were 539/1199 (45.0%).The endoscope positive subjects who do not complain symptoms were 465 in 1199 positive reflux esophagitis (38.8%). We compared endoscopic positive subjects without any complain by brief question by nursing staffs to endoscopic positive subjects with heartburn. Male gender, no obesity, absence of hiatus hernia, and low-grade esophagitis were associated with endoscopy-positive patients who do not complain of symptoms. The results of this study indicated correct detection of clinical symptoms of reflux esophagitis might be not easy with brief questioning by nursing staffs before endoscopic examination.

show abstract

Association between Skeletal Muscle Strength and Dysphagia among Chinese Community-Dwelling Elderly Adults

Zhang

Guo

Tang

et al. 2020

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Dysphagia in Adult Japanese Is Not Equivalent to the Grade of Endoscopic Reflux Esophagitis

Cited by 3 publications

References 20 publications

Safety and Efficacy of Long-Term Maintenance Therapy with Oral Dose of Rabeprazole 10 mg Once Daily in Japanese Patients with Reflux Esophagitis

Safety and Efficacy of Long-Term Maintenance Therapy with Oral Dose of Rabeprazole 10 mg Once Daily in Japanese Patients with Reflux Esophagitis

Brief Questioning by Nursing Staffs before Endoscopic Examination May Not Always Pick Up Clinical Symptoms of Endoscopic Reflux Esophagitis

Association between Skeletal Muscle Strength and Dysphagia among Chinese Community-Dwelling Elderly Adults

Contact Info

Product

Resources

About