Dysplasia Associated With Atypical Glandular Cells on Cervical Cytology

Sharpless, Kathryn E.; Schnatz, Peter F.; Mandavilli, Srinivas; Greene, John F.; Sorosky, Joel I.

doi:10.1097/01.aog.0000152350.10875.02

Cited by 74 publications

(51 citation statements)

References 21 publications

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“…In this study we tested 28 AGC liquid-based cytology for HPV DNA with posterior identification of 10 types of HPV DNA, 7 being high risk HPV DNA. The HPV associated disease ratio in our study was 50% which is in agreement with existing literature that reports rates which range from 11 to 53% (average 21%) [11].…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Clinical Implication of a Typical Glandular Cells; a Five Years Experience of a Single Institution in Portugal

Ribeiro¹,

Correia²,

Aguilar³

et al. 2015

Gynecol Obstet (Sunnyvale)

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Section: Discussionsupporting

confidence: 93%

“…The association to premalignant and malignant disease is seen is approximately 30% of the cases [5,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Clinical Implication of a Typical Glandular Cells; a Five Years Experience of a Single Institution in Portugal

Ribeiro¹,

Correia²,

Aguilar³

et al. 2015

Gynecol Obstet (Sunnyvale)

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“…ACG are divided in two groups, according to their estimated significance: "possibly non-neoplastic" or "cannot exclude highgrade intraepithelial lesion", as the Nomenclatura Brasileira para Laudos de Colpocitologia (Brazilian Nomenclature for Cervical Cytology Reporting). The recommended approach, indeed, is the same, implying recommendation of immediate investigation through colposcopy with histological evaluation (5,13) .…”

Section: Introductionmentioning

confidence: 99%

Clinical implications and histological correlation of atypical glandular cells found in cervicovaginal smears

Loos¹,

Coelho²,

França³

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Introduction: Atypical glandular cells (AGC) are carriers of insufficient nuclear abnormalities for the diagnosis of adenocarcinoma, but exceed the criteria for classification as reactive glandular cells. This is an uncommon diagnosis, which may be associated with neoplastic lesions. Objective: To evaluate the clinical significance of primary cytological diagnosis of AGC through correlation with results of subsequent cyto-histologic examination. Materials and methods: 10 years retrospective study based on cervical cytologic results indicating AGC, classified as "possibly non-neoplastic" or "cannot exclude high-grade intraepithelial lesion". It was performed cyto-histopathological correlation in cases that were submitted to subsequent histopathological examination up to two years after cervical cytology analysis. Results: AGC were reported in 380 (0.06%) exams, providing 160 cases with subsequent biopsy. 85 (53.1%) of these, presented benign changes and 75 (46.9%) neoplastic lesions. From 114 "possibly non-neoplastic" cytological results, 71 (62.3%) had benign histological changes, and 43 (37.7%) neoplastic lesions, corresponding to a negative predictive value (NPV) of 62.3%. In contrast, among the 46 AGC "cannot exclude high-grade intraepithelial lesion" results, 14 (30.4%) presented benign changes and 32 (69.6%) neoplastic lesions (positive predictive value [PPV] = 69.6%). Discussion: The high rate of cancer associated with the diagnosis of AGC reassures the importance of recognizing these atypical cells in pap smears. The classification of "possibly non-neoplastic" and "cannot exclude high-grade intraepithelial lesion" may suggest the origin of cytological changes. Conclusion: Our results reinforce the importance of adequate follow-up of patients with AGC diagnosis on cervical cytology.

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“…The follow-up rate with histologic diagnosis can be as high as 94.5% [9], while other studies reported less than half this number [10]. Significant pathology diagnosed histologically on follow-up ranges from 9% [11] to over 60% [12] of cases. Reports comparing the performance of different preparations demonstrate inconsistent results on the prevalence of AGC, with some reporting higher rates on ThinPrep over conventional preparations [6, 13, 14] and others finding the opposite [15, 16].…”

Section: Discussionmentioning

confidence: 99%

Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations

Fischer¹,

Cormier²

2018

Acta Cytologica

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Objective: Detecting glandular lesions is challenging by all Pap test methodologies. As the availability of data on identifying glandular abnormalities by SurePath is scarce, we investigated the detection rates and the correlation with histology follow-up. Study Design: A total of 105,927 cases (SurePath and conventional) were searched for the diagnosis of atypical glandular cells or higher glandular abnormalities (AGC+) with the corresponding histologic diagnosis. The associations between the Pap test methods and diagnostic categories were assessed by χ² test. Results: Overall, 0.32% of SurePath (159/49,375) and 0.29% of conventional (164/56,552) cases showed AGC+ (p = 0.38). Histology confirmed significant abnormalities in 42 versus 53.5% of the cases, respectively (p = 0.064); 72.7% (SurePath) versus 65.2% (conventional) of these were glandular in nature (p = 0.37). The diagnosis of neoplasia (favored or definitive) showed malignancy on follow-up in 100% of SurePath cases (12/12). In contrast, 82.1% of these conventional cases disclosed premalignant or malignant lesions by histology (p = 0.12). Conclusions: AGC+ cases showed higher prevalence on SurePath preparations. Conventional cases had more abnormalities on follow-up, while glandular lesions represented a higher proportion of abnormal histologies following SurePath AGC+s. The positive predictive value of favored or definite neoplasia was higher in SurePath cases. Overall, these differences were not statistically significant.

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Dysplasia Associated With Atypical Glandular Cells on Cervical Cytology

Abstract: These data suggest that women with atypical glandular cells are at substantial risk for dysplasia and malignancy. The rate of disease varies with the method of Pap test collection, age, presence of persistent AGUS Pap tests, and AGUS subclassification.

Cited by 74 publications

References 21 publications

Clinical Implication of a Typical Glandular Cells; a Five Years Experience of a Single Institution in Portugal

Clinical Implication of a Typical Glandular Cells; a Five Years Experience of a Single Institution in Portugal

Clinical implications and histological correlation of atypical glandular cells found in cervicovaginal smears

Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations

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