2019
DOI: 10.1016/j.yjmcc.2019.01.018
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Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis

Abstract: Microvascular dysfunction in the heart and its association with periarteriolar fibrosis may contribute to the diastolic dysfunction seen in heart failure with preserved ejection fraction. prevents global myocardial fibrosis in a pressure overloaded left ventricle by acting via its receptor, ST2 (encoded by the gene, Il1rl1); however, whether this cytokine can also modulate periarteriolar fibrosis remains unclear. We utilized two approaches to explore the role of IL-33/ST2 in periarteriolar fibrosis. First, we… Show more

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Cited by 22 publications
(23 citation statements)
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“…Furthermore, recent reports have con rmed that IL-33 promotes ST-2-dependent organ tissue brosis, such as lung [26], liver [27], and kidney brosis [28]. Conversely, IL-33 prevented global myocardial periarteriolar brosis in pressure-overloaded left ventricles [29]. However, whether and how this cytokine can modulate PF remains unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, recent reports have con rmed that IL-33 promotes ST-2-dependent organ tissue brosis, such as lung [26], liver [27], and kidney brosis [28]. Conversely, IL-33 prevented global myocardial periarteriolar brosis in pressure-overloaded left ventricles [29]. However, whether and how this cytokine can modulate PF remains unclear.…”
Section: Discussionmentioning
confidence: 99%
“…IL33 signals through suppression of tumorigenicity-2 (ST2), also called interleukin1 receptor-like 1 (IL1RL1), and exerts protective effects in the cardiovascular system. In HFpEF, myocardial periarteriolar fibrosis has recently been linked to the reduced activity of IL33 because of deficient expression of ST2 [100].…”
Section: From Systemic Inflammation To Diastolic LV Dysfunctionmentioning
confidence: 99%
“…The IL-33/IL-13 pathway is associated with the immunopathological process of liver fibrosis, and hepatic group 2 innate lymphoid cells (ILC2s) have been identified as fibrogenic immune cells in the murine liver [62]. It has been reported that IL-33 promotes fibrosis in many organs, including the liver [63], lungs [64], kidney [65] and heart [66]. In a murine model of schistosomiasis, schistosome eggs trapped tissue induced downregulation of miR-203-3p in HSCs.…”
Section: Anti-fibrogenic Role Of Mirnas In Schistosomiasismentioning
confidence: 99%