Dysregulation of Regulatory ncRNAs and Diseases

El-Gewely, Mohamed Raafat

doi:10.3390/ijms25010024

IJMS

2023

DOI: 10.3390/ijms25010024

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Dysregulation of Regulatory ncRNAs and Diseases

Mohamed Raafat El-Gewely

Abstract: Cancer was initially attributed to genetic mutations and gene alterations, which resemble genetic diseases caused by various modifications of a specific gene in the genome sequence [...]

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Cited by 15 publications

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Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Fang,

Xu,

Jin

et al. 2024

Macromolecular Bioscience

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Peripheral nerve injuries represent a prevalent and severe category of damage resulting from traumatic incidents. Predominantly, the deficiency in nerve regeneration can be ascribed to enduring inflammatory reactions, hence imposing substantial clinical implications for patients. Fisetin, a flavonoid derived from plants, is naturally present in an array of vegetables and fruits, including strawberries, apples, onions, and cucumbers. It exhibits immunomodulatory properties through the reduction of inflammation and oxidative stress. In the present research, a nerve defect was addressed for the first time utilizing a scaffold primed for controlled fisetin release. In this regard, fisetin‐loaded chitosan hydrogels were incorporated into the lumen of polycaprolactone (PCL) nerve guide conduits (NGCs). The hydrogel maintained a steady release of an appropriate fisetin dosage. The study outcomes indicated that the fisetin/chitosan/polycaprolactone (FIS/CS/PCL) NGCs amplified Schwann cell proliferation and neural expression, curtailed oxidative stress, alleviated inflammation, and improved functions, electrophysiological properties, and morphology. This pioneering scaffold has potential to contribute significantly to the field of neuroengineering.This article is protected by copyright. All rights reserved

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Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Fang,

Xu,

Jin

et al. 2024

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

Regulation of TGF-β/BMP signaling during osteoblast development by non-coding RNAs: Potential therapeutic applications

Saranya,

Selvamurugan

2024

Life Sciences

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Immune Subtypes and Characteristics of Endometrial Cancer Based on Immunogenes

Zhang,

Xu,

Wang

et al. 2024

CMAR

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Dysregulation of Regulatory ncRNAs and Diseases

Abstract: Cancer was initially attributed to genetic mutations and gene alterations, which resemble genetic diseases caused by various modifications of a specific gene in the genome sequence [...]

Cited by 15 publications

References 6 publications

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration

Regulation of TGF-β/BMP signaling during osteoblast development by non-coding RNAs: Potential therapeutic applications

Immune Subtypes and Characteristics of Endometrial Cancer Based on Immunogenes

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