(E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles as efficient Michael acceptors for cysteine: Real application in biological imaging

An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti

“…In this context, the synthesis of organic compounds including aromatic rings in their structure has been widely reported in the literature. The compounds with aromatic substructure have been reported to show a broad spectrum of pharmaceutical, agricultural, and chemical engineering applications and are scaffolding reagents for synthetic organic chemistry [1][2][3][4][5][6]. They are also ubiquitous structural units in biologically important molecules such as cyclooxygenase and -galactosidase inhibitors and anticancer porphyrins [7].…”

Synthesis and in silico analysis of the quantitative structure–activity relationship of heteroaryl–acrylonitriles as AChE inhibitors

“…In all cases, 1 H NMR analysis of all the novel derivatives revealed a single olefinic proton consistent with the formation of unique isomer E or Z. However, the derivatives were assigned to have thermodynamically more stable E configuration by considering E-acrylonitriles previously reported with similar structural characteristics [18,22,[32][33][34].…”

Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3-(pyridin-3-yl)acrylonitrile)

“…In addition, this family of compounds have been proved for having prominent biological properties as antifungal, antitumor, and antibacterial activities [3][4][5][6][7], as well as applications for the design of dendrimers [8] and uorescent probes for visualizing endogenous thiols in living cells [9,10]. They have also been reported in the literature as versatile building-blocks for molecules with potential biological or pharmaceutical applications [11][12][13][14][15][16][17].…”