E -2-Benzylidenebenzocycloalkanones. Stereostructure and NMR spectroscopic investigation

Investigation of Interaction of Some Chalcones and Cyclic Chalcone Analogues with Outer Mitochondrial Membrane by UV-VIS and Fluorescence Spectroscopy

“…Compounds 1b,c and 2b,c Figure 1 were synthesized, and their structures were characterized as described before [5,10]. Their structures were characterized by IR and 1 H NMR spectroscopy.…”

Synthesis and structure of some (E)-ferrocene-methylenecycloalkanones and their benzylidene analogs

“…8,9 Recently, we have synthesized some E-2-ferrocenemethylenebenzocyclanones and compared their electronic and stereochemical characteristics with the respective benzylidene analogues. 10,11 As a continuation of this work here we report on the synthesis and the spectroscopic investigation of some E-2-ferrocenemethylene-3 and E,E-diferrocenemethylenecycloalkanones 4 as well as their complete 5,6 and partial 7-11 benzylidene analogues (Figure 1). n = 1 (a), 2 (b), 3 (c); X = H (7), CH 3 (8), OCH 3 (9), NO 2 (10), N(CH 3 ) 2 (11).…”

“…10,11 The stereohomogeneous E,Econfiguration of 4a and 6a-c is proved by the symmetrical pattern of their NMR spectra. The change in substituents bonded to the cyclanone ring (arylmethylene or ferrocenylmethylene) has no significant influence on the structures and spectral characteristics in the new compounds.…”

“…In accordance with our earlier investigations the stereostructure (conformation) of E-2-benzylidene-and E-2-ferrocenmethylenebenzocyclanones depend on the size of the cyclanone ring. 10,11 Similar to the respective benzocyclanones, in the series 6 (dibenzylidenecyclanones) the molecule with 5-membered ring (6a) is almost fully planar: in the solid state the two benzylidene moieties subtend an angle of 10 º . 26 In the cyclohexanone (6b) and the cycloheptanone (6c) derivatives the molecules are more distorted and the conformers with out of plane aryl group to the C=C double bonds are preferred.…”

(E)-2-Benzylidenecycloalkanones XII.* Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry

“…Based on the literature, chalcones and cyclic chalcone analogues seem to be promising molecular tools to investigate changes of molecular surroundings both in solution and in biological systems [10]- [13]. Earlier results indicated that the ring size of the cyclic chalcone analogues has a remarkable impact on their spectroscopic properties [14]- [17]. In order to gain a better understanding, the dynamic interaction of the compounds with proteins, UV-VIS kinetic investigations of selected 4-X-chalcones (1c) and cyclic chalcone analogues: (E)-2-(4'-X-benzylidene)-1-indanones (2b) and (E)-2-(4'-X-benzylidene)-1-benzosuberones (4a, 4c) have been performed (Figure 1).…”