Information, Communication and Technology (ICT) was growing rapidly. E-commerce creates new economic activities through technology, especially in the field of trade. The main objective of the studied was to analyze the effect of e-commerce on national income. The analysis was performed by EC2SLS (Error Component-Two Stage Least Square) method. Analysis using panel data with cross section data of 114 countries in the 2016-2017 period. The data used were GDP data based on purchasing power parity (PPP); previous year's GDP; e-commerce users; ICT services exports and imports; government spending; investment (FDI); country dummy. The analysis shows that e-commerce had a significant effect on national income. E-commerce for 113 other countries had a positive influence of 0.0026% while e-commerce for indonesia had a positive influence of 0.0080%.