E15 Investigation of the effects of Phyllanthus niruri on in vitro calcium oxalate crystallization

Ramsout, Ronica; Rodgers, Allen L.; Webber, Dawn

doi:10.1016/s1569-9056(11)61164-0

Cited by 5 publications

(4 citation statements)

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“…Although the same method of evaluation was utilized in the study performed by Nishiura et al, those authors did not show a change in the number and size of calculi before and after the use of a P. niruri extract in individuals with urinary lithiasis ( 11 ). In contrast, it has been reported that P. niruri promoted a reduction in the number of calculi and their appearance in relation to the most fragile aspect of the calculi structure ( 7 , 17 - 19 ).…”

Section: Discussionmentioning

confidence: 84%

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

et al. 2018

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Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking.Objective:To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis.Materials and Methods:We studied 56 patients with kidney stones <10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P. niruri) and after a 12-week (wash out) Statistical analysis included ANOVA for repeated measures and Tukey's/McNemar's test for categorical variables. Significance was set at 5%.Results:Mean age was 44±9.2 and BMI was 27.2±4.4kg/m2. Thirty-six patients (64%) were women. There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5±20.4 to 56.2±21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58±22.5 to 69.1±28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3±15.1 to 51.3±34.7mg/gCr24-hour (p=0.008) from baseline to wash out. The kidney stones decreased from 3.2±2 to 2.0±2per patient (p<0.001). In hyperoxaluria patients, urinary oxalate reduced from 59.0±11.7 to 28.8±16.0mg/24-hour (p=0.0002), and in hyperuricosuria there was a decrease in urinary uric acid from 0.77±0.22 to 0.54±0.07mg/24-hour (p=0.0057).Conclusions: P.niruri intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P.niruri contributed to the elimination of urinary calculi.

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Section: Discussionmentioning

confidence: 84%

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

et al. 2018

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“…According to a study on the evaluation of patients with metabolic alterations at the baseline, a significant normalization of urinary uric acid and oxalate values occurred in those with hyperuricosuria and hyperoxaluria, respectively, and urine pH in the sample urinalysis did not change throughout that study and remained at a mean value between 6.0 and 6.1 [33][34][35]. In this study, there was a slight increase in the mean score of the urine pH from 6.03 ± 0.27 to 6.59 ± 0.31.…”

Section: Effect On Urinary Biochemicals Parametersmentioning

confidence: 99%

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

et al. 2020

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The study purpose was to investigate the effect of Phaseolus Vulgaris (PV) on urinary biochemical parameters among patients with kidney stones. We conducted a randomized controlled study among 60 patients with kidney stones (size < 10 mm) in the nephrology unit of both government and private hospitals, Al-Ahsa. Urinary volume, calcium, magnesium, potassium, oxalate, uric acid, and power of hydrogen (pH) were assessed before and after the intervention of giving 250 g of PV consumption as an extract thrice weekly (2.2 L to 2.5 L per week) for 6 weeks, which was compared with control. A ‘t’ test was used with the significance at 5%. Mean score of age was 44.5 ± 10.16 in PV group and 43.73 ± 9.79 in control. Four (13.3%) and two (6.7%) had family history of kidney stones. Body mass Index (BMI) mean was 26.44 ± 2.7 and 26.36 ± 2.65 in pre and post-test, respectively, which were significant (p = 0.01017). There were significant changes (p = 0.000) in urine volume from 1962 ± 152.8 to 2005 ± 148.8, calcium 205.4 ± 11.99 to 198.4 ± 12.52, potassium 44.07 ± 3.66 to 52.15 ± 4.37, oxalate 37.12 ± 5.38 to 33.02 ± 5.71, and uric acid 6.88 ± 0.7 to 6.31 ± 0.58. In conclusion, PV is effective management for the patients with kidney stones as it increases the urinary volume and enhances the elimination of small kidney stones.

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“…O extrato metanólico da planta inibiu moderadamente a xantina oxidase, apresentando concentração inibitória (IC 50 ) de 39,39 µg/mL. Ramsout et al (2011) avaliaram o efeito do extrato aquoso à 5% (v/v) sobre a cristalização de CaOx em urina sintética e real, incubadas por 2 h a 37 0 C. A cristalização foi monitorada pelas taxas de nucleação, agregação e crescimento de cristais de CaOx, avaliada por microscopia eletrônica de varredura. Na urina sintética ocorreu redução da taxa de crescimento com menores quantidades de cristais agregados, o que não foi observado em relação à urina real.…”

Section: Inibiu a Deposição De Cristais De Caox E A Incidência De Cálunclassified

Plantas medicinais no controle de urolitíase

Cruces

Patelli

Tashima

et al. 2013

Rev. bras. plantas med.

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Norte do Paraná (UENP/Bandeirantes).RESUMO: Plantas medicinais têm sido utilizadas mundialmente para o controle de urolitíases na medicina humana. A ocorrência desta afecção tem aumentado em humanos, ruminantes, cães e gatos. Nos animais, fatores patofisiológicos adquiridos, congênitos ou familiares podem estar envolvidos, havendo similaridade ao que se observa em seres humanos. Porém, apesar dos avanços nas pesquisas, o emprego de plantas medicinais na medicina veterinária, ainda é pouco utilizado. Dessa forma, objetivou-se apresentar uma revisão bibliográfica dos resultados do uso de plantas medicinais no controle de urolitíase. As plantas utilizadas são: Ammi visnaga, Bergenia ligulata, Cynodon dactylon, Herniaria hirsuta e Phyllanthus niruri. A atividade antilitogênica foi relacionada às alterações da composição iônica da urina, atividade diurética, inibição de cristalização e agregação de cristais. Destaca-se o uso de Phyllanthus niruri, pela eficácia na prevenção dos urólitos. Extratos de Phyllanthus niruri normalizaram níveis altos de cálcio urinário, desfavorecendo os estágios iniciais de formação dos urólitos. Adicionalmente, foram associados à elevação da filtração glomerular e excreção urinária de ácido úrico sugerindo utilização potencial não só como efeito lítico e preventivo das calculoses, mas também em pacientes hiperuricêmicos e portadores de insuficiência renal. A partir dos resultados relatados, pode-se concluir que os trabalhos apresentados pela literatura atual são capazes de comprovar os efeitos benéficos do uso de plantas medicinais no controle de urolitíase. Entretanto, ainda são escassos os estudos realizados em animais domésticos, predominando ensaios desenvolvidos em roedores. Palavras-chave: ervas medicinais, Phyllanthus niruri, urina, urólitos.ABSTRACT: Using medicinal plants in the control of urolithiasis. Medicinal plants have been used worldwide in the prevention of urolithiasis. The occurrence of this disease has increased in men, ruminants, dogs and cats. With regard to animals, acquired (congenital or hereditary) pathophysiological factors may be involved, a fact that bears similarity to what has been observed in humans. Yet, despite advances in research, the use of medicinal plants in veterinary medicine remains still underutilized. Thus, the purpose of this study is to conduct a literature review on the use of medicinal plants in the control of urolithiasis. The plants used are: Ammi visnaga, Bergenia ligulata, Cynodon dactylon, Herniaria hirsute and Phyllanthus niruri. Antilithogenic activity was related to changes in the ionic composition of urine, diuretic activity and inhibition of crystallization and aggregation of crystals. It is worth highlighting the use of Phyllanthus niruri due to its efficiency in the prevention of uroliths. Phyllanthus niruri extracts normalized high levels of urinary calcium, inhibiting the formation of uroliths in the initial stages. Additionally, they were associated with a higher glomerular filtration and higher urinary excretion of uric acid....

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E15 Investigation of the effects of Phyllanthus niruri on in vitro calcium oxalate crystallization

Cited by 5 publications

References 0 publications

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention

Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

Plantas medicinais no controle de urolitíase

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