EANM/SNMMI Guideline for<sup>18</sup>F-FDG Use in Inflammation and Infection

Jamar, François; Buscombe, J. R.; Chiti, Arturo; Christian, Paul E.; Delbeke, Dominique; Donohoe, Kevin J.; Israel, Ora; Martín-Comín, J.; Signore, Alberto

doi:10.2967/jnumed.112.112524

Cited by 518 publications

(353 citation statements)

References 115 publications

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“…Elevated blood glucose is known to reduce the uptake of 18 F-FDG into metabolic active cells in malignant diseases. 30 Guidelines for the clinical use of 18 F-FDG in inflammation and infection 31 also recommend the reduction of blood glucose to the lowest possible level. In studies on atherosclerosis, there is no consensus on a cutoff value.…”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

Johnsrud

Skagen

Seierstad

et al. 2019

Journal of Nuclear Cardiology

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Background. There is currently no consensus on the methodology for quantification of 18 F-FDG uptake in inflammation in atherosclerosis. In this study, we explore different methods for quantification of 18 F-FDG uptake in carotid atherosclerotic plaques and correlate the uptake values to histological assessments of inflammation.Methods and Results. Forty-four patients with atherosclerotic stenosis ‡70% of the internal carotid artery underwent 18 F-FDG PET/CT. Maximum standardized uptake values (SUV max ) from all plaque-containing slices were collected. SUV max for the single highest and the mean of multiple slices with and without blood background correction (by subtraction (cSUV) or by division (target-to-background ratio (TBR)) were calculated. Following endarterectomy 30 plaques were assessed histologically. The length of the plaques at CT was 6-32 mm. The 18 F-FDG uptake in the plaques was 1.15-2.66 for uncorrected SUVs, 1.16-3.19 for TBRs, and 0.20-1.79 for cSUVs. There were significant correlations between the different uptake values (r 5 0.57-0.99, P < 0.001). Methods with and without blood background correction showed similar, moderate correlations to the amount of inflammation assessed at histology (r 5 0.44-0.59, P < 0.02).Conclusions. In large stenotic carotid plaques, 18 F-FDG uptake reflects the inflammatory status as assessed at histology. Increasing number of PET slices or background correction did not change the correlation. (J Nucl Cardiol 2017)

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Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

Johnsrud

Skagen

Seierstad

et al. 2019

Journal of Nuclear Cardiology

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“…Activated inflammatory cells such as neutrophils, macrophages and lymphocytes present an increased FDG uptake, causing significant FDG accumulation during inflammation [12,13]. Hence, the slight specificity of FDG PET/CT emerges as a potential advantage in the management of patients with inflammatory or infectious diseases [14]. Moreover, FDG PET/CT seems to be useful in the setting of unexplained inflammatory syndrome and fever of unknown origin (FUO) in both the overall population [15][16][17][18] and immunosuppressed patients [19,20].…”

Section: Introductionmentioning

confidence: 99%

18F-FDG PET/CT for the Diagnosis of Malignant and Infectious Complications After Solid Organ Transplantation

Muller

Kessler

Caillard

et al. 2016

Nucl Med Mol Imaging

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Purpose Infection and malignancy represent two common complications after solid organ transplantation, which are often characterized by poorly specific clinical symptomatology. Herein, we have evaluated the role of 18 F-fluoro-2-deoxy-Dglucose (FDG) positron emission tomography/computed tomography (PET/CT) in this clinical setting. Methods Fifty-eight consecutive patients who underwent FDG PET/CT after kidney, lung or heart transplantation were included in this retrospective analysis. Twelve patients underwent FDG PET/CT to strengthen or confirm a diagnostic suspicion of malignancies. The remaining 46 patients presented with unexplained inflammatory syndrome, fever of unknown origin (FUO), CMV or EBV seroconversion during post-transplant follow-up without conclusive conventional imaging. FDG PET/CT results were compared to histology or to the finding obtained during a clinical/imaging follow-up period of at least 6 months after PET/CT study. Results Positive FDG PET/CT results were obtained in 18 (31 %) patients. In the remaining 40 (69 %) cases, FDG PET/CT was negative, showing exclusively a physiological radiotracer distribution. On the basis of a patient-based analysis, FDG PET/CT's sensitivity, specificity, PPV and NPV were respectively 78 %, 90 %, 78 % and 90 %, with a global accuracy of 86 %. FDG PET/CT was true positive in 14 patients with bacterial pneumonias (n = 4), pulmonary fungal infection (n = 1), histoplasmosis (n = 1), cutaneous abscess (n = 1), inflammatory disorder (sacroiliitis) (n = 1), lymphoma (n = 3) and NSCLC (n = 3). On the other hand, FDG PET/CT failed to detect lung bronchoalveolar adenocarcinoma, septicemia, endocarditis and graft-versus-host disease (GVHD), respectively, in four patients. FDG PET/CT contributed to adjusting the patient therapeutic strategy in 40 % of cases. Conclusions FDG PET/CT emerges as a valuable technique to manage complications in the post-transplantation period. FDG PET/CT should be considered in patients with severe unexplained inflammatory syndrome or FUO and inconclusive conventional imaging or to discriminate active from silent lesions previously detected by conventional imaging particularly when malignancy is suspected.

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“…Hangi sintigrafik çalışma olursa olsun doğru tanı için, standardize işaretleme yöntemi, görüntü çekim protokolü ve yorumlama kriterleri olmalıdır. Avrupa Nükleer Tıp Derneği gibi bilimsel derneklerce çeşitli uygulama kılavuzları yayınlanmış ve yayınlanmaya devam etmektedir (39,40,68). Mevcut olan hiçbir radyofarmasötik her durumda eşit fayda sağlamamaktadır.…”

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Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

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2017

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EANM/SNMMI Guideline for¹⁸F-FDG Use in Inflammation and Infection

Cited by 518 publications

References 115 publications

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

18F-FDG PET/CT for the Diagnosis of Malignant and Infectious Complications After Solid Organ Transplantation

Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

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EANM/SNMMI Guideline for18F-FDG Use in Inflammation and Infection

Cited by 518 publications

References 115 publications

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques

18F-FDG PET/CT for the Diagnosis of Malignant and Infectious Complications After Solid Organ Transplantation

Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

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Product

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EANM/SNMMI Guideline for¹⁸F-FDG Use in Inflammation and Infection