Early alteration of urinary exosomal aquaporin 1 and transforming growth factor β1 after release of unilateral pelviureteral junction obstruction

Li, Zhen Zhen; Zhao, Zhanzheng; Wen, Jian Guo; Xing, Lihong; Zhang, Hong; Zhang, Yan

doi:10.1016/j.jpedsurg.2011.12.024

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…Currently available clinical tests are not adequate for predicting the course of urinary tract obstruction. Li et al [ 47 ] have reported that AQP1 in urinary EVs could be a possible candidate marker. They observed that urinary exosomal release of AQP1 was reduced in patients with unilateral pelviureteral junction obstruction who underwent pyeloplasty.…”

Section: Aquaporins In Urinary Extracellular Vesicles As Potentialmentioning

confidence: 99%

Aquaporins in Urinary Extracellular Vesicles (Exosomes)

Oshikawa¹,

Sonoda²,

Ikeda³

2016

IJMS

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Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.

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Section: Aquaporins In Urinary Extracellular Vesicles As Potentialmentioning

confidence: 99%

Aquaporins in Urinary Extracellular Vesicles (Exosomes)

Oshikawa¹,

Sonoda²,

Ikeda³

2016

IJMS

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“…A PCN catheter should remain inserted for about 4-12 weeks [1], but patients with PCN drainage are at increased risk of further renal function loss and infection [4,11]. Transforming growth factor-β and urinary tubular enzymes have also been used to predict the recoverability of renal function after the relief from obstruction, though the efficacy and feasibility of these biological agents need further evaluation [14,15]. Renal biopsy may cause infection and bleeding, and given that the histopathological changes in the kidneys are often heterogeneous, the biopsy sample may not reflect the true extent of the effects of UPJO [11].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Recoverability of Renal Function after Pyeloplasty in Adults with Ureteropelvic Junction Obstruction

Wu¹,

Wei²,

Chen³

et al. 2018

Urol Int

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Background: This study aimed to identify factors predicting the recoverability of renal function after pyeloplasty in adult patients with ureteropelvic junction obstruction. Methods: We retrospectively reviewed 138 adults with unilateral renal obstruction-induced hydronephrosis and who underwent Anderson-Hynes dismembered pyeloplasty from January 2013 to January 2016. Hydronephrosis was classified preoperatively according to the Society for Fetal Urology (SFU) grading system. All patients underwent Doppler ultrasonography, excretory urography, computed tomography, and technetium-99m-diethylenetriamine pentaacetic acid radioisotope (99mTc DTPA) renography before and after surgery. Renal resistive index (RRI) and 99mTc DTPA renography were repeated at 1, 3, 6, and 12 months. Results: Multivariate analysis identified age, renal pelvic type, SFU grade, preoperative RRI, decline of RRI, and renal parenchyma to hydronephrosis area ratio (PHAR) as independent predictors of renal function recoverability after pyeloplasty. However, preoperative RRI and RRI decline were not significantly associated with recoverability of renal function in patients aged >35 years. Lower preoperative RRI, greater decline in RRI, higher PHAR, lower SFU grade, and extrarenal pelvis were associated with greater improvements in postoperative renal function. Conclusions: Preoperative differential renal function cannot independently predict the recoverability of postoperative renal function in adult patients with unilateral renal obstruction-induced hydronephrosis. SFU grade, renal pelvic type, PHAR, preoperative RRI, and decline in RRI were significantly associated with the recoverability of renal function in adult patients aged <35 years, while only SFU grade, renal pelvic type, and PHAR were significantly associated with renal function recoverability in patients aged ≥35 years. Renal function recovery was better in patients younger than 35 years when compared with older patients.

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“…Differences in renal AQP expression levels in normal vs AKI tissue could help identify AKI in patients. AQPs 1, 2 expression is reduced in AKI rat models [36] and children with renal blockage injury show reduced expression of AQP1 [38] . Evidence suggests that AQP-uEV concentration in patient urine can be used as a biomarker to determine AKI severity; Sonoda et al have identified changes in AQP1 concentration in uEV in AKI rats with early AKI, without reduced urine osmolality or increased urine volume.…”

Section: Aqp-ev In the Urinary Systemmentioning

confidence: 92%

“…uEVs, exosomes, microparticles) depending on the focus of the study and findings; within the body of this review all are discussed as EV. System Aquaporin/s identified EV terminology Pathology/treatment Experimental model Authors Urinary 2 Low density exosomes Healthy Human [25] 2 Exosome-like Hepatic disease Mouse & rat [26] 1, 2 & 7 Exosomes Healthy Human [28] 1 & 2 Exosomes Healthy Human [29] 2 Exosomes Healthy Human [31] 1 & 2 Exosomes Healthy Human [32] 2 Exosomes Healthy Human [33] 2 Exosomes Desmopressin treatment Human cell line [35] 1 & 2 uEVs Acute Kidney Injury Rat [36] 1 Exosomes Acute Kidney Injury Rat [37] 1 Exosomes Pelviureteric junction obstruction Human [38] 1 & 2 Exosomes Transplant Human [39] 2 Exosomes Nephrosis Human [40] 2 ...…”

Section: Introductionmentioning

confidence: 99%