Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis: A single-center experience

Al‐Mayouf, Sulaiman M.; Shaikh, Ahmad Al; Al-Sheikh, Haifa; Alshomar, Ahmad; Humaidan, Hind Al; Dalaan, A N Al; Saleh, Salman S Al

doi:10.4103/1319-2442.265452

Cited by 2 publications

(2 citation statements)

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“…Neurological diseases make up a considerable share of the new diagnoses that have been added to the list since then. 2 …”

Section: Introductionmentioning

confidence: 99%

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Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital

Dr Tooba Fateen,

Dr Nighat Sultana,

Dr Muhammad Sarwar

et al. 2023

Pak J Med Sci

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Objective: To find the incidence of various complications of therapeutic plasma exchange (TPE) in ICU admitted children and to determine their association with age, gender, blood group and diagnosis of the patients. Methods: In this observational study, data of 24 patients who underwent 125 sessions of TPE was collected from the Pediatric Intensive care unit (PICU) and Hematology department of The Children’s Hospital, Lahore from December 2020 to November 2021. Age, gender, blood group, indications and complications observed during and after the TPE procedure were documented on a pre-designed proforma. The data was analyzed by using SPSS version 23. Quantitative variables were presented in the form of mean and standard deviation. Qualitative variables like gender, blood groups, indications and complications of plasmapheresis were presented as frequency and percentage. Chi square test was applied for comparison of variables. Results: Among the 24 patients, 45.8% were of age group five to ten years with mean age of 7.58 years± 2.04 years and male to female ratio of 0.84:1. Guillain-Barré syndrome (GBS) and Neuromyelitis Optica spectrum disorder (NMO-SD) were the most prevalent among the patients who underwent TPE. Most common complication was hypotension (44.9%), others were febrile reactions (11.6%), unstable vital signs (14.5%) and allergic reactions (24.6%). Blood group, clinical condition and diagnosis of the patient showed significant association with the incidence of TPE related complications. Conclusion: The majority of problems caused by TPE are considered to be minor. Sudden fall in blood pressure, pruritus, urticarial rash and fever are the common adverse consequences among pediatric patients. Blood group and diagnosis of the patient can determine the development of such complications during plasmapheresis procedure. doi: https://doi.org/10.12669/pjms.39.4.7002 How to cite this: Fateen T, Sultana N, Sarwar M, Saqlain N. Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7002 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Neurological diseases make up a considerable share of the new diagnoses that have been added to the list since then. 2 …”

Section: Introductionmentioning

confidence: 99%

“…Neurological diseases make up a considerable share of the new diagnoses that have been added to the list since then. 2 Three to five different exchange operations are commonly included in a TPE course, which is performed every 24 to 48 hours. Exchange-dependent kinetics explain why this happens in the first place.…”

Section: Introductionmentioning

confidence: 99%

Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital

Dr Tooba Fateen,

Dr Nighat Sultana,

Dr Muhammad Sarwar

et al. 2023

Pak J Med Sci

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Efficiency of therapeutic plasma exchange in critically ill systemic rheumatologic diseases: A single‐center 9‐year experience

Guo,

Huang,

et al. 2024

Ther Apher Dial

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IntroductionTherapeutic plasma exchange (TPE), an effective method to eliminate harmful soluble mediators associated with tissue injury, serves as a crucial intervention for systemic rheumatologic diseases (SRDs). However, its value in critically ill SRDs remains uncertain. This retrospective study aims to evaluate the efficacy of TPE in SRDs.MethodsCritically ill SRD patients admitted to the department of intensive care unit of a large tertiary hospital receiving TPE from January 2011 to December 2019 were included.ResultsA total of 91 critically ill SRD patients received TPE were enrolled. Their mean age was 47.67 ± 16.35 years with a female predominance (n = 68). Significant decrease in SOFA score post‐TPE treatment was observed (p < 0.05). There were no TPE‐related fatalities. Improvement was observed in 64 (70.32%) patients.ConclusionThis study shows favorable clinical outcomes. TPE may be an acceptable treatment option for critically ill SRD patients.

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Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis: A single-center experience

Cited by 2 publications

References 20 publications

Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital

Complications of Therapeutic Plasma Exchange in pediatric patients: An experience at a tertiary care hospital

Efficiency of therapeutic plasma exchange in critically ill systemic rheumatologic diseases: A single‐center 9‐year experience

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