Early antithrombotic prophylaxis with low molecular weight heparin in neurosurgery

Kleindienst, Andrea; Harvey, H. B.; Mater, E.; Bronst, J.; Flack, Joseph E.; Herenz, K.; Haupt, Walter F.; Schön, R

doi:10.1007/s00701-003-0142-y

Cited by 72 publications

(57 citation statements)

References 15 publications

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“…[16][17][18][19][20][21] Three small randomized trials have also been completed. [22][23][24] In 68 patients with ICH, low-dose heparin starting on day 2 led to a statistically lower rate of PE when compared with 4th or 10th day of initiation.…”

Section: February 2015mentioning

confidence: 99%

Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After Intracerebral Hemorrhage?

Prabhakaran

Herbers

Khoury

et al. 2015

Stroke

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Background and Purpose— Prophylactic anticoagulation for deep venous thrombosis prevention after intracerebral hemorrhage (ICH) is safe. Current guidelines recommend prophylactic anticoagulation after cessation of hematoma growth. We aimed to evaluate nationwide trends in deep venous thrombosis prophylaxis after ICH. Methods— In an analysis of the Premier database, we identified adult patients with ICH ( International Classification of Diseases Ninth edition code 431) from 2006 to 2010 who survived to day 2 of hospitalization. We excluded those with trauma or who underwent craniotomy or angiography. We abstracted type of anticoagulant used and date of first administration. We used univariate statistics and multivariable logistic regression to assess factors associated with prophylactic anticoagulation after ICH. Results— Among 32 690 (mean age, 69.7 years; 50.1% men) patients with spontaneous ICH, 5395 (16.5%) patients received any prophylactic anticoagulation during the hospital stay. Among these patients, 2416 (44.8%) received prophylactic anticoagulation by day 2. The most commonly used agents were heparin (71.1%), enoxaparin (27.5%), and dalteparin (1.4%). The proportion of patients receiving prophylactic anticoagulation increased slightly during the study period from 14.3% to 18.0% ( P <0.01 for trend). Use of prophylactic anticoagulation varied by geographic region ( P <0.001) in the United States: Northeast (23.2%), South (19.0%), Midwest (10.8%), and West (9.8%). In multivariable analysis, geographic region remained an independent predictor of prophylactic anticoagulation. Conclusions— Less than 20% of patients with ICH receive anticoagulation for deep venous thrombosis in the United States. When used, the time to initiation is <2 days in less than half of the patients. Further study should focus on understanding variations in practice and emphasize guideline-driven care.

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Section: February 2015mentioning

confidence: 99%

Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After Intracerebral Hemorrhage?

Prabhakaran

Herbers

Khoury

et al. 2015

Stroke

View full text Add to dashboard Cite

show abstract

“…The majority of cases if they are not related to trauma, surgery or puncture; are due to ruptured renal lesions (such as angiomyolipomas [7][8][9]; however, vascular disorders [10,11] and anticoagulation therapy [12][13][14][15][16][17][18], may also be the underlying cause. Sometimes is not possible to find an abnormality responsible for the bleeding [19] Renal tumours account for 58% to 79% of cases of non-traumatic retroperitoneal haemorrhage [7,20].…”

Section: Introductionmentioning

confidence: 99%

Case report: Delayed spontaneous retroperitoneal haematoma after unilateral total hip replacement

Fairén¹,

Duart²,

Alonso³

et al. 2017

Rheumatol Orthop Med

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We present the case of a 59-year-old woman who developed a major spontaneous retroperitoneal haematoma after performing a unilateral total hip arthroplasty. We reviewed the literature to see that a retroperitoneal haematoma is a rare event which can potentially be life-threatening.In our patient, the abdominal pain instead of being acute, as it happens on the majority of retroperitoneal haematomas, it started at day five postop associated to a sensation of abdominal fullness. An urgent CT was ordered to achieve de diagnose.A selective angiographic embolization was employed to stop the bleeding. Even if a total hip arthroplasty is a safe procedure, we need to be alert on operated patients with abdominal pain after the surgery and perform a careful evaluation.

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“…Studies have shown that other risk factors for VTE include age, sex, ethnicity, blood type, length of hospital stay, operative duration, and coagulation status [3,6,[8][9][10]14,[25][26][27][28][29][30][31][32][33][34][35][36][37][38]. Standard prophylactic measures for VTE include chemical anticoagulation, mechanical prophylaxis, and increased ambulation during the post-operative period [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. This paper seeks to review the relevant and current literature on VTE in brain tumor patients, with particular focus on the risk factors and presenting symptoms of VTE, treatment options for those with VTE, and a review of current prophylactic measures for VTE.…”

Section: Introductionmentioning

confidence: 99%

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Coté¹,

Smith

2015

J Hematol Thrombo Dis

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Venous thromboembolism (VTE) is a relatively common and well-described condition, affecting approximately 1-2% of the general population. VTE can lead to significant morbidity and death via pulmonary embolism (PE). During the post-operative period, VTE occurs at higher rates due to natural thrombotic responses to injury and limited post-operative mobility. In general, rates of post-operative VTE are higher in patients undergoing operations for cranial and spinal lesions than for lesions of other types, a phenomenon that is not fully explained. Several studies have demonstrated that other risk factors for VTE include age, sex, ethnicity, hospital stay length, and coagulation state. Aggressive chemical and mechanical measures for VTE prophylaxis are indicated in the postoperative period to prevent the formation of VTE. Here we review the literature on VTE in brain tumor patients, with a focus on their etiology, diagnosis, treatment, and prophylaxis.

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Early antithrombotic prophylaxis with low molecular weight heparin in neurosurgery

Cited by 72 publications

References 15 publications

Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After Intracerebral Hemorrhage?

Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After Intracerebral Hemorrhage?

Case report: Delayed spontaneous retroperitoneal haematoma after unilateral total hip replacement

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

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