Early assessment of rapidly progressive interstitial pneumonia associated with amyopathic dermatomyositis

Miyazaki, Eishi; Ando, Masayuki; Muramatsu, Tomoko; Fukami, Tetsujiro; Matsuno, Osamu; Nureki, Shin-ichi; Ueno, Takamasa; Tsuda, Toshihide; Kumamoto, Toshihide

doi:10.1007/s10067-005-0147-4

Cited by 52 publications

(50 citation statements)

References 18 publications

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“…Regarding the anti-Jo-1 antibody, only one patient with chronic ILD-ADM had this antibody among the present ILD-ADM study. To date, several studies have reported a low incidence of anti-Jo-1 antibody in ILD-ADM patients [11][12][13][17][18][19]. The current results were consistent with those studies.…”

Section: Discussionsupporting

confidence: 92%

“…As ADM is a rare disease, previous studies of ILD-ADM included only one, or a few patients [7][8][9][10][11][12][13]. The present study investigated the highest number of patients with ILD-ADM so far.…”

Section: Discussionmentioning

confidence: 98%

“…To date, contradictory data have been reported in the prognosis of ILD-ADM. Previous studies, mainly from Asia, have demonstrated that ILD-ADM generally runs an aggressive course, leading to fatal respiratory failure [7][8][9][10][11][12]. In contrast, COTTIN et al [13] recently described a benign form of ILD-ADM.…”

Section: Discussionmentioning

confidence: 99%

“…Cyclosporine was given to eight patients, but five died. Several recent studies reported that early administration of cyclosporine might improve the prognosis of acute ILD-ADM [11,17]. Thus, the duration between the start of corticosteroids and addition of cyclosporine, and the duration between onset of respiratory symptoms and the start of cyclosporine among survivors and nonsurvivors was compared.…”

Section: ¡2092 7286¡2090mentioning

confidence: 99%

“…Several studies have demonstrated that rapidly progressive interstitial lung disease (ILD) with a poor prognosis occurs in patients with ADM [7][8][9][10][11][12]. These patients were often resistant to intensive therapy, such as highdose corticosteroids plus immunosuppressive agents, resulting in fatal respiratory failure.…”

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confidence: 99%

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Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

Eur Respir J

152

116

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The aim of the present study was to clarify the clinical characteristics and prognosis of patients with interstitial lung disease (ILD) associated with amyopathic dermatomyositis (ILD-ADM).The study consisted of 14 consecutive patients with ILD-ADM. Patients were classified into two categories, acute/subacute and chronic forms, according to the clinical presentation of ILD. The clinical features, responsiveness to therapy, and prognosis between the two forms were compared.Nine ILD-ADM patients were categorised as the acute/subacute form, and five as the chronic form. Arterial oxygen tension was significantly lower in the acute/subacute ILD than chronic ILD patients. On high-resolution computed tomography, ground-glass opacities were frequently found in the two forms, but consolidation was more common in acute/subacute ILD than chronic ILD. Bronchoalveolar lavage analysis showed higher numbers of total cells and lymphocytes in acute/subacute ILD than chronic ILD. Histologically, the most common finding was nonspecific interstitial pneumonia in the two forms, while diffuse alveolar damage was only found in acute/ subacute ILD. Acute/subacute ILD was generally resistant to therapy, while chronic ILD responded well. Notably, the mortality of acute/subacute ILD was much higher than that of chronic ILD (67 versus 0%, respectively).In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: ¡2092 7286¡2090mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Interstitial lung diseases associated with amyopathic dermatomyositis

Suda¹,

Fujisawa²,

Enomoto³

et al. 2006

Eur Respir J

152

116

View full text Add to dashboard Cite

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Evaluation and management of pulmonary disease in ataxia‐telangiectasia

McGrath‐Morrow

Gower

Rothblum-Oviatt³

et al. 2010

Pediatric Pulmonology

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Summary Ataxia-telangiectasia (A-T) is a rare autosomal recessive disorder caused by mutations in the ATM gene, resulting in faulty repair of breakages in double-stranded DNA. The clinical phenotype is complex, and is characterized by neurologic abnormalities, immunodeficiencies, susceptibility to malignancies, recurrent sinopulmonary infections, and cutaneous abnormalities. Lung disease is common in patients with A-T and often progresses with age and neurological decline. Diseases of the respiratory system cause significant morbidity and are a frequent cause of death in the A-T population. Lung disease in this population is thought to exhibit features of one or more of the following phenotypes: recurrent sinopulmonary infections with bronchiectasis, interstitial lung disease, and lung disease associated with neurological abnormalities. Here, we review available evidence and present expert opinion on the diagnosis, evaluation, and management of lung disease in A-T, as discussed in a recent multidisciplinary workshop. Although more data are emerging on this unique population, many recommendations are made based on similarities to other more well-studied diseases. Gaps in current knowledge and areas for future research in the field of pulmonary disease in A-T are also outlined.

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Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature

et al. 2008

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Amyopathic dermatomyositis (ADM) is recognized as a variant phenotype of dermatomyositis and characterized by typical skin manifestations without evidence of muscular inflammation. While interstitial lung disease (ILD) is occasionally found as one of the lung manifestations in ADM patients, the development of a pneumomediastinum and/or subcutaneous emphysema in this disease entity is one of the extremely rare pulmonary complications. These latter complicated pulmonary manifestations have been usually reported in idiopathic ADM with ILD without any other associated medical conditions. We report a case presented with the spontaneous pneumomediastinum and subcutaneous emphysema in both ADM and cryptogenic organizing pneumonia during adjuvant chemotherapy based on cyclophosphamide for breast cancer.

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Early assessment of rapidly progressive interstitial pneumonia associated with amyopathic dermatomyositis

Cited by 52 publications

References 18 publications

Interstitial lung diseases associated with amyopathic dermatomyositis

Interstitial lung diseases associated with amyopathic dermatomyositis

Evaluation and management of pulmonary disease in ataxia‐telangiectasia

Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature

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