Early auditory gamma band response abnormalities in first hospitalized schizophrenia

Taylor, Grantley W.; McCarley, Robert W.; Salisbury, Dean F.

doi:10.1016/b978-0-7020-5307-8.00009-0

Cited by 13 publications

(12 citation statements)

References 68 publications

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“…Here, the GBO occur at a lower frequency and with a lower degree of phase locking, a feature which is associated with slower reaction time and symptoms of visual hallucinations, thought disorder, and disorganization. Taylor et al [18] analyzed the early auditory GBO occurring during presentation of standard (noncounted) stimuli during the auditory oddball P300 paradigm in which the counted oddball stimuli differ in frequency from the standard stimuli; they found both reduced power and lower PLF in first-episode schizophrenia, confirming previous studies in patients with chronic schizophrenia. No abnormalities were found in a similar study of individuals at clinical high risk for psychosis [19].…”

Section: Importance Of γ Band Oscillation Activity In Brain Circuit Cmentioning

confidence: 68%

Gamma band oscillations

McNally

McCarley²

2016

Current Opinion in Psychiatry

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120

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Purpose of review We review our current understanding of abnormal γ band oscillations in schizophrenia, their association with symptoms and the underlying cortical circuit abnormality, with a particular focus on the role of fast-spiking parvalbumin gamma-aminobutyric acid (GABA) neurons in the disease state. Recent findings Clinical electrophysiological studies of schizophrenia patients and pharmacological models of the disorder show an increase in spontaneous γ band activity (not stimulus-evoked) measures. These findings provide a crucial link between preclinical and clinical work examining the role of γ band activity in schizophrenia. MRI-based experiments measuring cortical GABA provides evidence supporting impaired GABAergic neurotransmission in schizophrenia patients, which is correlated with γ band activity level. Several studies suggest that stimulation of the cortical circuitry, directly or via subcortical structures, has the potential to modulate cortical γ activity, and improve cognitive function. Summary Abnormal γ band activity is observed in patients with schizophrenia and disease models in animals, and is suggested to underlie the psychosis and cognitive/perceptual deficits. Convergent evidence from both clinical and preclinical studies suggest the central factor in γ band abnormalities is impaired GABAergic neurotransmission, particularly in a subclass of neurons which express parvalbumin. Rescue of γ band abnormalities presents an intriguing option for therapeutic intervention.

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Section: Importance Of γ Band Oscillation Activity In Brain Circuit Cmentioning

confidence: 68%

Gamma band oscillations

McNally

McCarley²

2016

Current Opinion in Psychiatry

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120

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“…Auditory oddball tasks were used in 6 first episode studies. Evoked power was decreased in one (Taylor, McCarley et al 2013). In another, there was no overall…”

Section: First Episode Psychosismentioning

confidence: 88%

“…These comprised a total of 1125 participants; 522 patients and 603 healthy controls. Most patients had a diagnosis of schizophrenia, defined by DSM-IV criteria in 11 studies (Gallinat, Winterer et al 2004, Yeragani, Cashmere et al 2006, Kikuchi, Koenig et al 2007, Flynn, Alexander et al 2008, Spencer, Salisbury et al 2008, Williams, Whitford et al 2009a, Williams, Whitford et al 2009b, Minzenberg, Firl et al 2010, Kikuchi, Hashimoto et al 2011, Taylor, McCarley et al 2013, Tada, Nagai et al 2014, ICD-10 criteria in 3 , Garakh, Zaytseva et al 2015, Ramyead, Studerus et al 2016, and a composite of these in 4 (Slewa-Younan, Gordon et al 2004, Symond, Harris et al 2005). Five studies were of participants who were naïve to antipsychotic medication (Kikuchi, Koenig et al 2007, Kikuchi, Hashimoto et al 2011, Ramyead, Studerus et al 2016, Yeragani, Cashmere et al 2006.…”

Section: First Episode Psychosismentioning

confidence: 99%

Gamma band oscillations in the early phase of psychosis: A systematic review

Reilly

Nottage

Studerus

et al. 2018

Neuroscience & Biobehavioral Reviews

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Abnormal gamma oscillations, measured by electroencephalography (EEG), have been associated with chronic psychotic disorders, but their prevalence in the early phase of psychosis is less clear. We sought to address this by systematically reviewing the relevant literature. We searched for EEG studies of gamma band oscillations in subjects at high risk for psychosis and in patients with first episode psychosis. The following measures of gamma oscillations were extracted: resting power, evoked power, induced power, connectivity and peak frequency. Forty-five studies with a total of 3099 participants were included. There were potential sources of bias in the study designs and potential artefacts. Although there were few consistent findings, several studies reported decreased evoked or induced power in both high risk subjects and first episode patients. Studies using larger samples with serial EEG measurements, and designs that minimise artefacts that occur at the gamma frequency may advance work in this area.

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“…Quantifying between-groups differences on voltage over the entire ERP time-range, frequency variations in neural oscillations as a function of time, and integrating information over the whole head all may capture additional complexity of neural responding not evident in ERP peak voltage measurements (30) and may help elucidate differences between nosologically similar diagnostic groups (23,31). Quantifying event-related oscillations (EROs) has revealed early gamma band abnormalities during the auditory oddball task which are both heritable in twin studies (32) and present in first episode (33) and chronic SZ (34). Early gamma responses have been relatively understudied in BPD but have been reported as heritable but not abnormal in one study of non-psychotic bipolar patients (35) so this response may prove to be a candidate endophenotype of SZ.…”

mentioning

confidence: 99%

Event-Related Potential and Time-Frequency Endophenotypes for Schizophrenia and Psychotic Bipolar Disorder

Ethridge¹,

Hamm²,

Pearlson³

et al. 2015

Biological Psychiatry

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Background The investigators compared event related potential (ERP) amplitude measurements and event-related oscillations across a broad frequency range during an auditory oddball task using a comprehensive analysis approach to describe shared and unique neural auditory processing characteristics among healthy subjects (HP), schizophrenia probands (SZ) and their first-degree relatives (SZrel), and bipolar disorder I with psychosis probands (BDP) and their first-degree relatives (BDPrel). Methods This Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) sample consisted of clinically stable SZ (n=229) and BDP (n=188), healthy subjects (HP, n=284), SZrel (n=264) and BDPrel (n=239). They were administered an auditory oddball task in the electroencephalography (EEG) environment. Principal components analysis (PCA) derived data-driven frequency bands for measurement of evoked power. Spatial PCA reduced ERP and frequency data to component waveforms for each subject. Clusters of time-bins with significant group differences on magnitude of response were assessed for patterns of proband/relative differences from HP and familiality. Results Nine variables survived a linear discriminant analysis between HP, SZ, and BDP. Of those, two showed evidence (deficit in relatives and familiality) as genetic risk markers more specific to SZ (N1, P3b) while one was specific to BDP (P2) and one for psychosis in general (N2). Conclusions This study provides support for both shared and unique deficits in early sensory and late cognitive processing across psychotic diagnostic groups Additional ERP and time-frequency component alterations (frontal N2/P2, late high, early mid and low- frequency) may provide insight into deficits in underlying neural architecture and potential protective/compensatory mechanisms in unaffected relatives.

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Early auditory gamma band response abnormalities in first hospitalized schizophrenia

Cited by 13 publications

References 68 publications

Gamma band oscillations

Gamma band oscillations

Gamma band oscillations in the early phase of psychosis: A systematic review

Event-Related Potential and Time-Frequency Endophenotypes for Schizophrenia and Psychotic Bipolar Disorder

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