Early B Cell Development

Eibel, Hermann

doi:10.1007/978-3-319-22714-6_1

Agammaglobulinemia

2015

DOI: 10.1007/978-3-319-22714-6_1

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Early B Cell Development

Hermann Eibel

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2020

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“…B lymphopoiesis follows a series of well-defined, highly regulated processes to confer broad immunity to foreign pathogens and simultaneously prevent self-recognition (1,2). Developing B cells depend on extracellular cues to facilitate maturation from the common lymphoid progenitor (CLP) to a mature plasma cell (3,4).…”

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confidence: 99%

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling

Greenberg

Monlish

Bartnett

et al. 2020

The Journal of Immunology

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The tetraspanin CD53 has been implicated in B cell development and function. CD53 is a transcriptional target of EBF1, a critical transcription factor for early B cell development. Further, human deficiency of CD53 results in recurrent infections and reduced serum Igs. Although prior studies have indicated a role for CD53 in regulating mature B cells, its role in early B cell development is not well understood. In this study, we show that CD53 expression, which is minimal on hematopoietic stem and progenitor cells, increases throughout bone marrow B cell maturation, and mice lacking CD53 have significantly decreased bone marrow, splenic, lymphatic, and peripheral B cells. Mixed bone marrow chimeras show that CD53 functions cell autonomously to promote B lymphopoiesis. Cd53−/− mice have reduced surface expression of IL-7Rα and diminished phosphatidylinositol 3 kinase and JAK/STAT signaling in prepro- and pro-B cells. Signaling through these pathways via IL-7R is essential for early B cell survival and transition from the pro-B to pre-B cell developmental stage. Indeed, we find increased apoptosis in developing B cells and an associated reduction in pre-B and immature B cell populations in the absence of CD53. Coimmunoprecipitation and proximity ligation studies demonstrate physical interaction between CD53 and IL-7R. Together, these data, to our knowledge, suggest a novel role for CD53 during IL-7 signaling to promote early B cell differentiation.

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mentioning

confidence: 99%

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling

Greenberg

Monlish

Bartnett

et al. 2020

The Journal of Immunology

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Early B Cell Development

Cited by 1 publication

References 121 publications

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling

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