Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

Stojanović, Vesna; Vuckovic, Nada; Barišić, Nenad; Srdić, Biljana; Doronjski, Aleksandra; Antic, Andrija

doi:10.1038/pr.2014.50

Cited by 8 publications

(12 citation statements)

References 32 publications

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“…While a direct effect of the Ucns on IL-18 is not known, inhibition by Ucn2 of the renal angiotensin system, which has IL-18-stimulatory activity [38], may have contributed to its suppression. As with Il-18, CysC is promoted as a marker of renal impairment [39], and increased protein/expression has been demonstrated in the kidney following hypoxia [40]. Cystatin C is also postulated to have a role in remodeling via its actions to inhibit formation and activity of cathepsins (cysteine proteases that degrade ECM proteins), and stimulate accumulation of ECM proteins (including collagen I, collagen III, and fibronectin) [41].…”

Section: Discussionmentioning

confidence: 99%

Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine

Rademaker¹,

Ellmers²,

Charles³

et al. 2015

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine

Rademaker¹,

Ellmers²,

Charles³

et al. 2015

International Journal of Cardiology

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“…KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased in post ischemic kidney (Stojanović et al, 2014) [12]. Urinary KIM-1 levels are strongly related to tubular KIM-1 expression in experimental and in human renal disease (Waanders et al, 2010) [13].…”

Section: Introductionmentioning

confidence: 99%

Urinary Kidney Injury Molocule-1 Level in Preterm Neonates with Respiratory Distress Syndrome

Youssef¹,

Abdel-Salam²,

Saeed³

et al. 2016

OJPed

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Background: Despite recent advances in perinatal and neonatal care in respiratory distress syndrome (RDS) prevention and treatment, a considerable number of these neonates suffer from acute kidney injury (AKI), and it is associated with poor outcome as an independent risk factor. KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased in post ischemic kidney. Aim: The aim is to detect the value of urinary KIM-1 measurement as an early predictor marker of acute kidney injury in preterm neonates with respiratory distress syndrome. Patients and methods: The study included 30 preterm newborn with (RDS) ≤36 weeks during the period from October 2014 to March 2015. Also the study included 30 apparently healthy newborn ≤36 weeks as controls. They were selected from NICU of Manshiate Elbakry hospital Cairo, Egypt. uKIM-1 along with serum creatinine levels and eGFR were assessed in days 1 of life for both groups and in day 3 for cases. Results: In day one of life, we found a significant increase in uKIM-1 levels in preterm newborn with RDS compared to their controls (2.88 ± 1.01 ng/ml and 0.95 ± 0.52 ng/ml respectively (p = 0.001)). There is no significant difference between both groups regarding serum creatinine and eGFR. In day 3 of life, preterm with RDS had significant decrease in uKIM-1 levels compared to day 1 of life with significant increase in non-survivor compared to survivor group ( 2.30 ± 1.56 ng/ml and 1.30 ± 0.90 ng/ml respectively (p = 0.03)). The sensitivity and specificity of uKIM-1 and serum creatinine was calculated (100.00%, 86.67% and 33.33%; 95.00%) respectively. Conclusion: Preterm neonate with RDS is at high risk of developing AKI. Early and serial uKIM-1 measurements can be used as a non-invasive indicator of kidney injury in premature newborn with RDS.

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“…While acute and high level exposure to toxic metals causes acute GFR changes, chronic and low level exposures can lead to mild clinical manifestations, which is really obscure that can prevent the accurate diagnosis. In these conditions, Cyctatin C seems to be a better and more sensitive biomarker than creatinine [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…In these conditions, Cyctatin C seems to be a better biomarker than creatinine. The studies aiming the most accurate calculation of GFR are still continuing in scientific area [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

Bal

Güngör

Çelik

et al. 2015

Turkish Journal of Biochemistry

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Objective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared.Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels.Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant difference between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups.Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.Özet: Amaç: Çocuklarda akut civa maruziyetine bağlı hızlı glomerüler fitrasyon hızı azalmalarında sistatin C düze-yinin böbrek fonksiyonlarını değerlendirme açısından Ceylan Bal et al.: Children with acute exposure of mercury 259 kreatinine üstün olup olmadığını belirlemeyi amaçladık. Ayrıca kreatinin ve/veya sistatin C kullanılan 8 ayrı glomerular filtrasyon hızı hesaplama formülünü birbiriyle karşılaştırdık.Metod: Civa maruziyeti yaşayan 39 çocuğun serum üre, kreatinin ve sistatin C düzeyleri ölçüldü. Glomerular filtrasyon hızı 8 farklı formülle hesaplandı. Hasta grubu civa seviyelerine göre üç subgruba bölündü. Bulgular: Hastaların sistatin C ve civa düzeyleri kontrol grubundan anlamlı olarak farklı bulundu (p<0.001). Kreatinin ve üre açısından iki grup arasında anlamlı bir fark bulunmadı (p=0.913, p=0.236). Serum kreatinini ve boy kullanılarak veya bunlara ilaveten üre değerleri kullanıla-rak yapılan GFR hesaplamalarında hasta ve kontrol grupları arasında anlamlı bir fark yokken (sırasıyla, p=0.069, p=0.559, p=0.424, p=0.945 ), yalnızca sistatin C veya buna ek olarak kreatinin, üre ve boyun kullanıldığı GFR hesaplamalarında hasta ve kontrol grupları arasında anlamlı bir fark vardı (sırasıyla, ...

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Early biomarkers of renal injury and protective effect of erythropoietin on kidneys of asphyxiated newborn rats

Cited by 8 publications

References 32 publications

Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine

Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine

Urinary Kidney Injury Molocule-1 Level in Preterm Neonates with Respiratory Distress Syndrome

Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

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