Early cerebrovascular and long-term neurological modifications ensue following juvenile mild traumatic brain injury in male mice

Ichkova, Aleksandra; Rodriguez‐Grande, Beatriz; Zub, Emma; Saudi, Amel; Fournier, Marie‐Line; Aussudre, Justine; Sicard, Pierre; Obenaus, André; Marchi, Nicola; Badaut, Jérôme

doi:10.1016/j.nbd.2020.104952

Cited by 29 publications

(47 citation statements)

References 61 publications

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“…These injured rats exhibited significantly lower neurological severity score (NSS) and neurobehavioral score (NBS) at 2 and 24 h after injury (Katz et al, 2015). Additionally, Ichkova et al (2020) found that an early cerebrovascular pathology including BBB disruption may contribute to long-term behavioral deficits in mice following experimental juvenile mTBI, while the exact topographical coherence and the direct causality between these two events require further investigation.…”

Section: Blood-brain Barrier Dysfunction and Cognitive Impairment In mentioning

confidence: 93%

“…Using peripherally injected radiotracer, 14 C-sucrose and 99m Tcalbumin, Logsdon et al (2018) found BBB disruption by mild blast exposure in just 15 min. Moreover, based on immunostaining of endogenous IgG, BBB disruption was detected in both adult and juvenile mice from 6 h to 2 days after mTBI (Laurer et al, 2001;Huh et al, 2008;Ichkova et al, 2020). By administering exogenous tracers Evans blue dye or fluoresce labeled albumin, the BBB breakdown was also detected from the mTBI between 1 and 24 h after mTBI based on extravascular leakages (Yang et al, 2013;Chen et al, 2014;Katz et al, 2015;Yates et al, 2017).…”

Section: Blood-brain Barrier Dysfunction In Acute and Subacute Stagesmentioning

confidence: 99%

“…Functional assessments revealed that repeated impacts cause sustained decreases of CBF and cerebrovascular reactivity, along with neuronal function deficits and astrogliosis in peri-contusion areas (Adams et al, 2018). In addition, mTBI can elicit an early and long-lasting cerebrovascular dysfunction in juvenile mice (Wendel et al, 2018;Ichkova et al, 2020), accompanied by astrocyte response and gliovascular changes (Rodriguez-Grande et al, 2018;Clément et al, 2020). Furthermore, pediatric mTBI can morphologically alter the vasculature of the ipsilateral corpus callosum differentially between the acute/subacute stage and the chronic stage (Wendel et al, 2018).…”

Section: Blood-brain Barrier Dysfunction In the Chronic Stage Of Mildmentioning

confidence: 99%

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Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Guo

et al. 2020

Front. Physiol.

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Mild traumatic brain injury (mTBI) represents more than 80% of total TBI cases and is a robust environmental risk factor for neurodegenerative diseases including Alzheimer's disease (AD). Besides direct neuronal injury and neuroinflammation, bloodbrain barrier (BBB) dysfunction is also a hallmark event of the pathological cascades after mTBI. However, the vascular link between BBB impairment caused by mTBI and subsequent neurodegeneration remains undefined. In this review, we focus on the preclinical evidence from murine models of BBB dysfunction in mTBI and provide potential mechanistic links between BBB disruption and the development of neurodegenerative diseases.

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Section: Blood-brain Barrier Dysfunction and Cognitive Impairment In mentioning

confidence: 93%

Section: Blood-brain Barrier Dysfunction In Acute and Subacute Stagesmentioning

confidence: 99%

Section: Blood-brain Barrier Dysfunction In the Chronic Stage Of Mildmentioning

confidence: 99%

See 1 more Smart Citation

Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Guo

et al. 2020

Front. Physiol.

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“…In the visible and NIR-spectrum, there are also multiple isosbestic points (390, 422, 452, 500, 530, 545, 570, 584, and 797 nm), where signals reflect total hemoglobin (Hb T ), regardless of the hemoglobin oxygenation level [ 31 , 102 , 103 ]. Owing to this capability, OAI has been widely used to visualize blood vessels and microcirculation, and to measure blood oxygenation levels, both experimentally in multiple organs [ 93 , 104 ] and clinically in patients [ 105 ]. Additionally, OAI has the potential to image blood flow velocity, although this has proved challenging at clinically relevant depths due to poor velocity signal-to-noise ratio [ 106 , 107 , 108 ].…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

“…Park et al used this approach to visualize inflammation related to Alzheimer’s disease (AD) changes by visualizing more CDnir7 in the AD mouse cerebral cortex compared to that of normal mice [ 92 ]. Another study demonstrated the potential of utilizing dual-wavelength OAI (at 750 nm and 850 nm) to monitor cerebrovascular damage and hypo-oxygenation following brain injury, which is increasingly linked to neurodegenerative disease [ 93 ].…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

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Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of “light in” and “sound out” offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications.

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Photoacoustic imaging in brain disorders: Current progress and clinical applications

Liu,

Li,

Pang

et al. 2024

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Over the past few decades, the number of patients with neurological diseases has increased significantly, posing huge challenges and opportunities for the development of brain imaging technology. As a hybrid imaging method combining optical excitation and acoustic detection techniques, photoacoustic tomography (PAT), has experienced rapid development, due to high optical contrast and spatial resolution at depth inside tissues. With the development of lasers, ultrasonic detectors, and data computations, PAT has been widely applied for the diagnosis of oncology, dermatosis, etc. However, the energy of light and ultrasound would be greatly attenuated while penetrating the skull, due to the reflection, absorption, and scattering effects, resulting in limited application of PAT in brain imaging. In this review, we summarized the achievements of PAT and its application in the detection of brain diseases including glioma, stroke, traumatic brain injury, Alzheimer's disease, epilepsy, and Parkinson's disease. Moreover, various PAT systems and multi‐modality photoacoustic imaging are introduced for potential clinical applications. Finally, the challenges and current limitations of PAT for further brain imaging are also discussed.

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Early cerebrovascular and long-term neurological modifications ensue following juvenile mild traumatic brain injury in male mice

Cited by 29 publications

References 61 publications

Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Blood–Brain Barrier Dysfunction in Mild Traumatic Brain Injury: Evidence From Preclinical Murine Models

Optoacoustic Imaging in Inflammation

Photoacoustic imaging in brain disorders: Current progress and clinical applications

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