Early changes in capillary flow and transport following missile wounds

Rybeck, B; Lewis, David H.; Sandegård, J; Seeman, T

doi:10.1016/0026-2862(75)90031-x

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…In zones C and D a significant increase in creatine phosphate in comparison to control muscle tissue was observed in the penicillin-treated animals. This could be due to the early hyperemia in these zones as found in isotope and angiographic studies [26,32], possibly in combination with a pro tective effect of penicillin G against progres sive bacterial invasion [13].…”

Section: Discussionmentioning

confidence: 99%

Effects of Penicillin G on Local Metabolic Changes in Skeletal Muscle following High Velocity Missile Injury

Almskog¹,

Haljamäe²,

Nordström³

et al. 1984

Eur Surg Res

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The effect of systemic penicillin G treatment on the local tissue damage 12 h after a high velocity missile injury in skeletal muscle has been studied in pigs (n = 13). Blood pressure, rectal temperature, hemoglobin concentrations, hematocrits, blood gases and acid base balances were followed and the tissue levels of ATP, creatine phosphate, glucose-6-phosphate, glucose and lactate were determined in control skeletal muscle as well as in muscle samples taken from the wound area. After 12 h all devitalized tissue was debrided and weighed. Penicillin G treatment slightly diminished the local tissue metabolic deterioration and significantly reduced the amount of debrided tissue as compared to untreated animals. It may be concluded that early treatment with penicillin G will considerably diminish the local tissue damage during the first 12-hour period following a high velocity missile injury.

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Section: Discussionmentioning

confidence: 99%