Early changes of protein-kinase (glycogen-synthetase kinase) in denervated muscle

Bergamini, Ettore; Paoli, Anna A. de

doi:10.1016/0014-4886(74)90049-1

Experimental Neurology

1974

DOI: 10.1016/0014-4886(74)90049-1

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Early changes of protein-kinase (glycogen-synthetase kinase) in denervated muscle

Ettore Bergamini

Anna A. de Paoli

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1977

1983

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Cited by 3 publications

References 11 publications

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Effect of denervation on glycogen metabolism in fast and slow muscle of rat

Moruzzi

Bergamini

1983

Muscle and Nerve

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The postdenervation changes in glycogen metabolism were explored in fast (extensor digitorum longus, EDL), and slow (soleus, S) muscle of rat. During the first 12-14 hours after denervation, glycogen accumulates to a similar content in the two muscles, an effect reproduced by paralysis. Increase in the molecular weight of glycogen and decrease in the turnover rate of similar degree occur. During the ensuing 12-24 hours the glycogen concentration decreases in EDL (but not in S). This decrease is influenced by factors such as muscle type, longer or shorter nerve stump, age, and previous training of the animal. In both EDL and S, the rate of glucose incorporation into glycogen and the glycogen synthase [l/(l + D)] activity were depressed by denervation. The cAMP concentration increased 36 hours after denervation. This may have consequences on the muscle sensitivity to hormones. In fact, at this time, insulin did not increase glycogen synthase I activity or the glycogen content (with the exception of glycogen in S) and the effects of epinephrine on glycogen metabolism became more significant.

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Effect of denervation on glycogen metabolism in fast and slow muscle of rat

Moruzzi

Bergamini

1983

Muscle and Nerve

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Covalent phosphorylation in the regulation of glycogen synthase activity

Roach

Larner

1977

Mol Cell Biochem

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Effect of denervation on muscle glycogen synthase kinase activity

DePaoli-Roach

Villar-Palasí

Bergamini

1978

Experimental Neurology

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Early changes of protein-kinase (glycogen-synthetase kinase) in denervated muscle

Cited by 3 publications

References 11 publications

Effect of denervation on glycogen metabolism in fast and slow muscle of rat

Effect of denervation on glycogen metabolism in fast and slow muscle of rat

Covalent phosphorylation in the regulation of glycogen synthase activity

Effect of denervation on muscle glycogen synthase kinase activity

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