Early cleavage: an additional predictor of high implantation rate following elective single embryo transfer

Giorgetti, C.; Hans, E.; Terriou, Philippe; Salzmann, J.; Barry, B.; Chabert-Orsini, V.; Chinchole, J. M.; Franquebalme, J. P.; Glowaczower, E; Sitri, M.-C.; Thibault, M.; Roulier, R.

doi:10.1016/s1472-6483(10)60768-7

Cited by 53 publications

(32 citation statements)

References 55 publications

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“…Moreover, although it is currently recommended to preferentially select early cleaved embryos for ET, our data failed to show any relationship between early cleavage and the onset of pregnancy, as previously reported in patients eligible for eSET by Thurin et al (19) and recently confirmed (30). However, this conclusion is not shared by other authors (23,31,32), attesting to the need of further investigation about the predictive value of this morphologic marker.…”

contrasting

confidence: 58%

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Sifer¹,

Sermondade²,

Poncelet³

et al. 2011

Fertility and Sterility

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contrasting

confidence: 58%

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Sifer¹,

Sermondade²,

Poncelet³

et al. 2011

Fertility and Sterility

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“…Furthermore, blastocysts quality was better when early cleavage was present, with a higher proportion of good quality blastocysts in the group of early cleavage embryos. This finding confirms the value of early cleavage as a strong indicator, not only for blastocyst formation but also for its quality (Lundin et al, 2001;neuber et al, 2003;Van Montfoort et al, 2004;Giorgetti et al, 2007), which appears to have a very close relation with implantation rates and the success of blastocyst transfer (Balaban et al, 2000). Embryo morphology at day three has been reported to be a good predictor for the chances of an embryo to achieve the blastocyst stage (Rijnders & Jansen 1998;Stone et al, 2005;nomura et al, 2007).…”

Section: Resultssupporting

confidence: 75%

Embryo early cleavage, number of blastomeres and morphology at day three as factors to predict blastocyst development

Mackenna¹,

Crosby²,

Zegers‐Hochschild³

2013

JBRA Assisted Reproduction

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Copyright -Todos os direitos reservados a SBRA -Sociedade Brasileira de Reprodução AssistidaEmbryo early cleavage, number of blastomeres and morphology at day three as factors to predict blastocyst development Clivagem precoce do embrião, número de blastocistos e morfologia embrionária no dia 3 como fatores preditivos para o desenvolvimento até blastocisto ABSTRACTObjective: the objective of this study is to evaluate markers of embryo quality, applied on day three of in vitro culture, in their capacity to predict whether embryos will reach blastocyst stage. Methods: a retrospective analysis of embryology database coming from 2772 zygotes obtained in 564 oocyte retrievals was performed; embryos were observed from day one to five: 23 to 26 hours after insemination all zygotes were evaluated to assess early cleavage, the number of blastomeres and embryo morphology were registered on day three and blastocyst formation was evaluated on day five; early first cleavage, number of blastomeres and embryo morphology at day three were correlated with embryo development until day five. Results: blastocyst formation rate was 36% in embryos with early cleavage and 19% in embryos without early the probability of a good quality embryo (grade 1 and 2a) at day three to reach the blastocyst stage was 48%, which was significantly higher than the chances of lower quality embryos. Conclusion: factors reported in this study -early cleavage, number of blastomeres and embryo morphology -are key words: blastocyst, expanded blastocyst, early cleavage, blastomere number, embryo morphology. RESUMENObjetivo: el objetivo del presente trabajo es evaluar los marcadores de calidad embrionaria, observados el tercer día de cultivo, para predecir el desarrollo del embrión hasta blastocisto. Métodos: se realizó un análisis retrospectivo de la base de datos del Laboratorio de Embriología, que proviene de 2772 cigotos obtenidos de 564 aspiraciones foliculares; los embriones fueron evaluados desde el día uno al quinto de desarrollo, registrando lo siguiente, 23 a 26 horas después de la inseminación, todos los cigotos fueron evaluados para determinar el clivaje temprano; el día 3 de desarrollo se evaluó el número de blastómeros y morfología embrionaria; el día quinto se evaluó la formación de un blastocisto, se correlacionó el clivaje temprano, el número de blastomeros y la morfología embrionariaa con el desarrollo embrionario hasta el día quinto. Resultados: la tasa de blastulación fue 36% en embriones con clivaje temprano y 19% en los embriones sin -día 3, la probabilidad de los embriones de buena calidad (grado 1 y 2a) en día 3 de desarrollo de alcanzar el estadío de blastocisto fue de 48%, que fue significativamente mejor que la probabilidad de los embriones de peor morfología. Conclusión: los factores reportados en este estudioclivaje temprano, número de blastomeros y morfología embrionaria -son útiles para decidir el cultivo prolongado in vitro hasta día quinto de desarrollo embrionario.

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“…In addition to developmental speed, there are other morphological characteristics involved in embryo evaluation such as zygote quality, early cleavage at 25 h after insemination or microinjection, blastomere symmetry, extent of fragmentation, and the presence of multi-nucleation at the 4-or 8-cell stage [21][22][23][24][25]. It has been suggested that a cumulative embryo classification scheme that encompasses all the above criteria is urgently needed to improve the efficiency of embryo assessment [26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Zhao

Liu

et al. 2019

Gynecol Obstet Invest

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Background/Aim: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. Methods: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group. Results: In the ET group, the clinical pregnancy and live birth rates of the > 10-cell transfer patients were comparable with those of the 8-cell transfer group (62.67 vs. 69.27%, 60.00 vs. 59.90%, respectively); however, the miscarriage rate of > 10-cell transfers was significantly lower than that of 8-cell transfers (4.26 vs. 13.53%, p < 0.05). In the FET group, there were no statistically significant differences found in the clinical pregnancy, live birth, and miscarriage rates between one > 10-cell-derived and one 8-cell-derived blastocyst transfers (71.04 vs. 65.78%, 59.02 vs. 54.19%, and 16.92 vs. 17.62%, respectively). Conclusions: The results suggested that > 10- and 8-cell, good quality embryos on day 3, had comparable viability and clinical outcomes.

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Early cleavage: an additional predictor of high implantation rate following elective single embryo transfer

Cited by 53 publications

References 55 publications

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Biological predictive criteria for clinical pregnancy after elective single embryo transfer

Embryo early cleavage, number of blastomeres and morphology at day three as factors to predict blastocyst development

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

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