Early clinical experience with resorbable poly-5D/95L-lactide (PLA95) plate system for treating distal radius fractures

Chang, Ing Lin; Yang, Jen Chang; Lee, Sheng Yang; Wang, Li Fen; Hu, Hsin Tai; Yang, Sung Yu; Lin, Hwang Chi

doi:10.1016/j.jds.2012.09.009

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Most commercial resorbable synthetic polymer membranes are based on aliphatic polyesters, such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(ε-caprolactone) (PCL), or their copolymers, to match the resorption time period for various clinical needs [10]. Among these polymers, a novel copolymer composed of poly-5D/95L-lactide (PLA95) has been successfully used in distal radius fractures [11] and craniomaxillofacial applications like skull flap fixation [12] and facial fracture fixation [13] due to its relatively strong mechanical properties. The feasibility of using PLA95 resorbable GTR membranes is worth exploring.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications

et al. 2019

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The guided tissue regeneration (GTR) membrane is a barrier intended to maintain a space for alveolar bone and periodontal ligament tissue regeneration but prevent the migration of fast-growing soft tissue into the defect sites. This study evaluated the physical properties, in vivo animal study, and clinical efficacy of hydrophilic PLA95/β-TCP GTR membranes prepared by electrospinning (ES). The morphology and cytotoxicity of ES PLA95/β-TCP membranes were evaluated by SEM and 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) respectively. The cementum and bone height were measured by an animal study at 8 and 16 weeks after surgery. Fifteen periodontal patients were selected for the clinical trial by using a commercial product and the ES PLA95/β-TCP membrane. Radiographs and various indexes were measured six months before and after surgery. The average fiber diameter for this ES PLA95/β-TCP membrane was 2.37 ± 0.86 µm. The MTT result for the ES PLA95/β-TCP membrane showed negative for cytotoxicity. The significant differences in the cementum and bone height were observed between empty control and the ES PLA95/β-TCP membrane in the animal model (p < 0.05). Clinical trial results showed clinical attachment level (CAL) of both control and ES PLA95/β-TCP groups, with a significant difference from the pre-surgery results after six months. This study demonstrated that the ES PLA95/β-TCP membrane can be used as an alternative GTR membrane for clinical applications.

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Section: Introductionmentioning

confidence: 99%