Early dental loss in Sjögren's syndrome

Baudet-Pommel, Martine; Albuisson, Éliane; Kémény, Jean-Louis; Falvard, F.; Ristori, Jean‐Michel; Fraysse, M.P.; Sauvezie, B

doi:10.1016/0030-4220(94)90143-0

Cited by 46 publications

(21 citation statements)

References 29 publications

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“…It is relevant that our patients with low salivary IL-1Ra had early dental loss. The role of IL-1 in caries, which is better documented in SS [35] than periodontal disease [36], has not been investigated. The correlation of a marked decrease with early dental loss suggests that the reduction of IL-1Ra production (or its cause) precedes by several years the first symptom of dry mouth.…”

Section: Discussionmentioning

confidence: 99%

IL-1 receptor antagonist in saliva; characterization in normal saliva and reduced concentration in Sjo¨gren's syndrome (SS)

Dubost¹,

Perrier²,

Afane³

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe characterization of a salivary factor cross-reacting with IL-1 receptor antagonist (IL-1Ra) is described. The apparent molecular weights of two species were 23 kD, consistent with the secreted peptide (sIL-1Ra), and 20 kD, consistent with the intracellular peptide (icIL-1Ra). It had an inhibitory activity on IL-1-stimulated fibroblasts, which is characteristic of IL-1Ra. Its source was the oral mucosa and not the salivary glands. Saliva from patients with SS contained significantly less IL-1Ra than saliva from controls. The decrease was marked in patients with early dental loss but whose xerostomia was still partial. In SS, the salivary IL-1/IL-1Ra imbalance may promote inflammatory lesions in the mouth and impede mucosal cell differentiation.

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Section: Discussionmentioning

confidence: 99%

IL-1 receptor antagonist in saliva; characterization in normal saliva and reduced concentration in Sjo¨gren's syndrome (SS)

Dubost¹,

Perrier²,

Afane³

et al. 1996

Clinical and Experimental Immunology

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“…It was found that in patients with SS 62% of the subjects were completely or partially edentulous (>12 teeth loss) compared with 21% in the control patient group 18. Two thirds of the Sjögren patients had lost the teeth before the age of 45 compared with 10% in the control group.…”

Section: Treatment Of Oral Infectionsmentioning

confidence: 93%

Treatment of oral dryness related complaints (xerostomia) in Sjogren's syndrome

Reijden

Vissink

Veerman

et al. 1999

Annals of the Rheumatic Diseases

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Primary Sjögren's syndrome (SS) is a systemic autoimmune disorder characterised by a chronic, progressive loss of salivary and lacrimal function resulting in symptoms of oral and ocular dryness. The involvement of exocrine glands is the result of a focal, periductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells.1 As a consequence, major changes occur in both the salivary flow rate and salivary composition. 2-9

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“…Dry mouth affects 10-30% of people. 1 The clinical effects of hyposalivation are increased prevalence of rampant caries, mucosal infections and salivary gland disease, [2][3][4][5] which significantly impact upon quality of life (QoL). 6,7 People with dry mouth have difficulties in eating, swallowing and speaking, and tend to have reduced self-esteem.…”

Section: Introductionmentioning

confidence: 99%