The degree and variants of structural changes in the vessels of the skin are important pathomorphological signs of the degree of tissue damage and potential possibilities and the course of its regeneration in various skin injuries, including burns. Objective: to identify arteries and veins with 3D optical coherence tomography during the experiment, describing their distinctive features. Materials and methods. To identify the vessels on OCT images of the skin, the rabbit ear was examined in vivo over the superficially located central artery and marginal vein and the vascular-free zone with a needle mark in the lumen of the vessel. Histo-tomographic comparisons were performed. Result. OCT signs of arterial and venous vessels are formulated.