Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

Sharma, Praveen; Sahni, Narinder Singh; Tibshirani, Robert; Skaane, Per; Urdal, Petter; Berghagen, Hege; Jensen, Mette Munk; Kristiansen, Lena; Moen, Cecilie; Sharma, Pradeep; Zaka, Alia; Arnes, Jarle B.; Sauer, Torill; Akslen, Lars A.; Schlichting, Ellen; Børresen-Dale, Anne Lise; Lönneborg, Anders

doi:10.1186/bcr1203

Cited by 120 publications

(115 citation statements)

References 21 publications

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“…11,12 Tumour-recruited BMDC are likely to initiate differentiation and effector programs during their mobilisation from the bone marrow, which might be detectable during their transition in the blood. 13,14 The report of signatures derived from peripheral blood mononuclear cells (PBMC) gene expression profiles and associated with breast, 15 renal, 16,17 pulmonary, 18 bladder 19 and digestive cancers 8,9,20 further corroborates these observations. The aim of this study was to demonstrate whether the feasibility of identifying gene expression signatures in PBMC was able to discriminate patients with AP and CRC from subjects without these lesions.…”

Section: Introductionsupporting

confidence: 66%

“…20 Similar results have been reported for other type of tumours, such as breast, bladder, small cell lung cancer and renal carcinoma. [15][16][17][18][19] In particular, different panels of peripheral blood biomarkers based on gene expression have been described in recent studies to differentiate CRC from controls. Han et al identified and validated a five-gene combination that could discriminate CRC from non-CRC samples with sensitivity and specificity of 94% and 77% respectively.…”

mentioning

confidence: 99%

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A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Nichita

Ciarloni

Monnier-Benoit³

et al. 2014

Aliment Pharmacol Ther

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These authors are regarded as joint first authors, having contributed equally to the manuscript. SUMMARY BackgroundEarly detection and treatment of colorectal adenomatous polyps (AP) and colorectal cancer (CRC) is associated with decreased mortality for CRC. However, accurate, non-invasive and compliant tests to screen for AP and early stages of CRC are not yet available. A blood-based screening test is highly attractive due to limited invasiveness and high acceptance rate among patients.

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Section: Introductionsupporting

confidence: 66%

mentioning

confidence: 99%

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Nichita

Ciarloni

Monnier-Benoit³

et al. 2014

Aliment Pharmacol Ther

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“…28 A study comparing DNA methylation profiles between WBC and EBV-transformed LCL from the same individuals found that the majority of genes have similar 3 H]-methyl acceptance assay and concluded that the two assays had good and DNA methylation status of specific sequences has also been found to be correlated with neutrophil count, suggesting different cell types have alternative ways to regulate expression of their genome. 30 While such evidence supports the presence of differential methylation patterns in different blood cell subsets, it cannot readily explain some of our results, such as why MN DNA methylation correlates so closely with WBC methylation. We might expect that Gran, which represents a larger proportion of cells in the blood (70%), would be more correlated with WBC DNA methylation profile.…”

Section: Discussionmentioning

confidence: 41%

Global methylation profiles in DNA from different blood cell types

et al. 2011

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“…This concept has received increasing interest by those examining diverse disorders including autoimmunity, asthma, osteoporosis, Huntington's disease and breast cancer (Borovecki et al 2005, Hakonarson et al 2005, Liu et al 2005, Olsen et al 2004, Sharma et al 2005). Blood is a particularly fitting surrogate for atherosclerotic tissue, because it contains the inflammatory cells such as monocytes that are involved in its pathogenesis (Hansson 2005).…”

Section: Blood As a Tissue Surrogatementioning

confidence: 99%

Genomic Analysis of Circulating Cells: A Window Into Atherosclerosis

Kang

Patino

Matoba

et al. 2006

Trends in Cardiovascular Medicine

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Translational studies using genomic techniques in cardiovascular diseases are still in their infancy. Access to disease-associated cardiovascular tissues from patients has been a major impediment to progress in contrast to the diagnostic advances made by oncologists using gene expression on readily available tumor samples. Nonetheless, progress is being made for atherosclerosis by carefully designed experiments using diseased tissue or surrogate specimens. This review details the rationale and findings of a study using freshly isolated blood mononuclear cells from patients undergoing carotid endarterectomy due to atherosclerotic stenosis and from matched normal subjects. Using this cardiovascular tissue surrogate, the mRNA levels of the Finkel-Biskis-Jinkins osteosarcoma (FOS) gene in circulating monocytes were found to correlate with atherosclerosis severity in patients, and with HMG CoA reductase inhibitor (statin) therapy in normal subjects. The major finding of this investigation is discussed in relation to observations from other human atherosclerosis gene expression studies. These distinct studies converge to demonstrate the unequivocal importance of inflammation in atherosclerosis. Although the clinical utility of the specific findings remains open, the identification of similar genes by different investigations serves to validate their reports. They also provide us with insights into pathogenesis that may impact future translational applications. Diagnostic markers of inflammation and atherosclerosisBased on our current understanding of atherosclerosis, the pathogenesis of this leading cause of morbidity and mortality in westernized societies is best described by chronic vascular inflammation that starts early in life and exacerbates with aging (Glass and Witztum 2001, Hansson 2005). Multiple hereditary and environmental factors contribute to the initiation and progression of this disease (Lusis 2000). However, some well established clinical risk factors such as low density lipoprotein (LDL) and the metabolic syndrome (including obesity and insulin-resistance, diabetes) and basic factors such as angiotensin II all appear to promote oxidative stress and inflammation (Daugherty and Cassis 2004, Glass and Witztum 2001, Libby 2002. Though a number of molecules linked to inflammation have been proposed for use as atherosclerosis markers, C-reactive protein (CRP) has gained prominence because of its association with increased cardiovascular risk in clinical trials (Jain and Ridker 2005). Revealing insights into statins' mechanism of action, the recent clinical trial PROVE IT-TIMI 22 separated the cholesterol lowering and anti-inflammatory effects of statin therapy by demonstrating the independent and additive predictive values of serum cholesterol and CRP levels on cardiovascular events, respectively (Jain andRidker 2005, Ridker et al. 2005). A question that follows such fundamental observations is whether there exist other predictive markers that have equal or greater sensitivity and specificity. Th...

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Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

Cited by 120 publications

References 21 publications

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer

Global methylation profiles in DNA from different blood cell types

Genomic Analysis of Circulating Cells: A Window Into Atherosclerosis

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