Early detection of kidney dysfunction in Egyptian patients with beta-thalassemia major

Bekhit, Osama; Dash, Hanaa H. El; Ahmed, Marwa S

doi:10.1016/j.epag.2017.02.002

Cited by 10 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Glomerular capillary wall stretching, and subsequent endothelial and epithelial injury, can induce the transudation of macromolecules into the mesangium and glomerular dysfunction, which may cause a progressive decline in GFR [ 19 ]. Bekhit et al [ 20 ] showed that the serum creatinine was higher in 40% of thalassemic compared with controls, but within a normal range, while the GFR was significantly lower in thalassemic patients compared with the controls. In addition, other studies found classical kidney function impairment (elevated serum creatinine and decreased eGFR) and early glomerular function impairment markers in children with beta-TM compared with controls [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Aldudak et al [ 28 ] illustrated an increased level of urinary protein/creatinine ratio in children with beta-TM. Bekhit et al [ 20 ] demonstrated increased urinary calcium in 26% of patients and increased urinary uric acid in 38% of patients. This may be explained by a decreased reabsorption of filtered uric acid from damaged renal tubules, combined with rapid erythrocyte turnover and excess uric acid urinary excretion [ 21 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ongazyooth et al [ 42 ] found that tubular defects were more common in splenectomized patients. In addition, Bekhit et al [ 20 ] reported higher levels of urinary NAG in splenectomized patients than in patients with splenomegaly. Belhoul et al [ 43 ] stated that, after splenectomy, the transaminases were higher and serum albumin was lower compared with nonsplenectomized patients.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

et al. 2021

View full text Add to dashboard Cite

Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C (p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls (p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr (p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

et al. 2021

View full text Add to dashboard Cite

show abstract

“…1 Patofisiologi talasemia mayor mencakup 3 faktor utama, yaitu anemia kronis dan hemolisis, eritropoesis yang tidak efektif, kelebihan besi, dan toksisitas kelasi besi. 2 Tata laksana yang lebih baik bagi penyandang talasemia-β mayor berdampak peningkatan kelangsungan hidup, tetapi berisiko mengalami kelebihan besi pada berbagai organ, seperti hati, pankreas, dan jantung, terutama bila konsumsi kelasi besi tidak optimal. Pada keadaan ini, keterlibatan ginjal masih belum banyak diperhatikan.…”

unclassified

“…Penyebab pasti disfungsi ginjal pada talasemia-β mayor belum diketahui sepenuhnya, tetapi dipastikan bahwa penyebabnya bersifat multifaktorial. [1][2][3] Saat ini, penanda kerusakan ginjal yang digunakan adalah kadar kreatinin serum. Pemeriksaan kreatinin tidak dapat digunakan untuk mendeteksi gangguan fungsi ginjal secara dini karena peningkatan kadar kreatinin serum mulai muncul ketika telah terjadi penurunan fungsi ginjal yang signifikan.…”

unclassified

Evaluasi Fungsi Ginjal pada Penyandang Talasemia-β Mayor Anak

Manurung

Susanah

Gurnida

2019

View full text Add to dashboard Cite

Latar belakang. Informasi keterlibatan ginjal pada penyandang talasemia-β mayor anak masih sedikit. Disfungsi ginjal dipengaruhi berbagai faktor seperti anemia kronis, hipoksia kronis, dan hemosiderosis. Neutrophil gelatinase associated lipocaline urin (NGALu) merupakan penanda biologis dini yang sensitif dan spesifik terhadap gangguan ginjal. Tujuan. Menilai disfungsi ginjal pada penyandang talasemia-β mayor anak menggunakan NGALu.Metode. Penelitian dengan rancang potong lintang dilaksanakan Oktober–November 2018. Subjek adalah penyandang talasemia β mayor anak di RS. Hasan Sadikin yang menggunakan kelasi besi deferiprondan dipilih secara consecutive sampling. Heteroanamnesis pada orang tua mengenai riwayat penyakit dan frekuensi transfusi. Terhadap subjek penelitian dilakukan pemeriksaan feritin serum, kreatinin serum, dan NGALu. Uji statistik menggunakan uji korelasi rank Spearman dengan nilai kemaknaan p<0,05.Hasil. Sebanyak 71 subjek yang memenuhi kriteria penelitian, terdiri dari 46 laki-laki dan 25 perempuan. Kadar rerata kreatinin serum 0,38±0,08 mg/dL, median feritin 2897,1 ng/mL, median NGALu 13,8 ng/mL. Peningkatan kadar NGALu ditemukan 11 (15%) subjek. Didapatkan korelasi negatif antara frekuensi transfusi dan kadar NGALu (r= -0,294, p=0,006). Tidak terdapat korelasi baik antara feritin serum dengan kreatinin serum maupun feritin serum dan NGALuKesimpulan. Disfungsi ginjal sudah terindikasi terjadi pada penyandang talasemia-β mayor anak.

show abstract

Hyperuricemia, urine uric excretion, and associated complications in thalassemia patients

et al. 2019

View full text Add to dashboard Cite

Early detection of kidney dysfunction in Egyptian patients with beta-thalassemia major

Cited by 10 publications

References 20 publications

Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Evaluasi Fungsi Ginjal pada Penyandang Talasemia-β Mayor Anak

Hyperuricemia, urine uric excretion, and associated complications in thalassemia patients

Contact Info

Product

Resources

About