Early Detection of Lung Cancer With Laser-Induced Fluorescence Endoscopy and Spectrofluorometry

Kusunoki, Yoko; Imamura, Fumio; Uda, Hiroshi; Mano, Masayuki; Horai, Takeshi

doi:10.1378/chest.118.6.1776

Cited by 101 publications

(79 citation statements)

References 16 publications

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“…Auto fluorescence emission was blocked by the thickened layer of the bronchus in subjects with chronic inflammation. It remains difficult to predict pathological diagnosis from the observed grade of auto fluorescence, as studies have found that some lesions identified as class III turned out to be inflammatory lesions on biopsy (22,23). Although the specificity of AF in our study was statistically significantly lower than that of WL, we do not think that this difference is clinically relevant.…”

Section: Discussioncontrasting

confidence: 83%

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

et al. 2011

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Section: Discussioncontrasting

confidence: 83%

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

et al. 2011

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“…Examples of translational research of fluorescence spectroscopy for cancer detection in vivo include studies for cervical cancer, [12][13][14] lung cancer, 15 colon cancer, 16 and oral neoplasia. 17 …”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

144

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Various types of optical spectroscopy have been investigated as methods to effect a non-invasive, real-time in-situ assessment of tissue pathology. All of these methods have one basic principle in common: the optical spectrum of a tissue contains information about the biochemical composition and/or the structure of the tissue, and that information conveys diagnostic information. The biochemical information can be obtained by measuring absorption, fluorescence, or Raman scattering signals. Structural and morphological information may be obtained by techniques that assess the elastic-scattering properties of tissue. These basic approaches are useful for the detection of cancer as well as for other diagnostic applications such as hemoglobin saturation, intra-luminal detection of atherosclerosis, and simply the identification of different tissue types during procedures. Optical spectroscopic measurements can also be employed in the management of disease treatment. The site-specific pharmacokinetics of chemotherapy and photodynamic therapy agents can be used to customize dosage to the patient, and diagnostic spectroscopy can be used to monitor response to treatment. In recent years clinical studies have provided indications of potential efficacy, and some of these modalities are now entering a translational research stage, with an eye to approval and commercialization. A benefit of these methods is their inherent low cost and ease of implementation, generally mediated with small portable instruments, not requiring any specialized facilities, and eventually not requiring expert interpretation. This paper reviews briefly the most common methods of diagnostic optical spectroscopy, and reviews in greater depth recent clinical translational research invoking scattering spectroscopy as the enabling technology, which has been the experience of the authors.

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24] Images are also much easier to interpret for the examining doctor than results presented from selected positions. For some applications exogenous substances providing high fluorescence signals can be utilized.…”

Section: Introductionmentioning

confidence: 99%

Compact medical fluorosensor for minimally invasive tissue characterization

Klinteberg

Andreasson

Sandström

et al. 2005

Review of Scientific Instruments

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A compact fiber-optic point-measuring fluorosensor fully adapted to clinical studies is described. The system can use two excitation wavelengths, 337 and 405nm, obtained from a nitrogen laser directly, or after dye laser conversion, respectively. The image intensifier used in the spectrometer can be gated with a variable time delay, allowing also time-resolved spectra to be extracted, with a time resolution of about 4ns. Moreover, diffusely scattered white light can be spectrally recorded. The system is fully computer controlled enabling short recording times in clinical application, which are illustrated.

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Early Detection of Lung Cancer With Laser-Induced Fluorescence Endoscopy and Spectrofluorometry

Cited by 101 publications

References 16 publications

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Compact medical fluorosensor for minimally invasive tissue characterization

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