Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Alchera, Elisa; Monieri, Matteo; Maturi, Mirko; Locatelli, Irene; Locatelli, Erica; Tortorella, Silvia; Sacchi, Angela; Corti, Angelo; Nebuloni, Manuela; Lucianò, Roberta; Pederzoli, Filippo; Montorsi, Francesco; Salonia, Andrea; Meyer, Sandra; Jose, Jithin; Giustetto, Pierangela; Franchini, Mauro Comes; Curnis, Flavio; Alfano, Massimo

doi:10.1016/j.pacs.2022.100400

Cited by 19 publications

(31 citation statements)

References 55 publications

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“…At present, GNRs have four main applications in the biological imaging field: near-infrared (NIR) fluorescence imaging, [44] photoacoustic imaging, [45] two-photon fluorescence imaging, [46,47] X-ray computed tomography (X-CT). [48] Simultaneously, with the unique optical properties of GNRs, excellent drug loading properties and biocompatibility of MSN, GNR@MSN nanoparticles can serve as the tumor imaging and therapeutical platforms.…”

Section: Biological Imagingmentioning

confidence: 99%

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Ma,

Li,

Ying

et al. 2024

ChemMedChem

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For unique surface plasmon absorption and fluorescence characteristics, gold nanorods have been developed and widely employed in the biomedical field. However, limitations still exist due their low specific surface area, instability and tendency agglomerate in cytoplasm. Mesoporous silica materials have been broadly applied in field of catalysts, adsorbents, nanoreactors, and drug carriers due to its unique mesoporous structure, highly comparative surface area, good stability and biocompatibility. Therefore, coating gold nanorods with a dendritic mesopore channels can effectively prevent particle agglomeration, while increasing the specific surface area and drug loading efficiency. This review discusses the advancements of GNR@MSN in synthetic process, bio‐imaging technique and tumor therapy. Additionally, the further application of GNR@MSN in imaging‐guided treatment modalities is explored, while its promising superior application prospect is highlighted. Finally, the issues related to in vivo studies are critically examined for facilitating the transition of this promising nanoplatform into clinical trials.

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Section: Biological Imagingmentioning

confidence: 99%

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Ma,

Li,

Ying

et al. 2024

ChemMedChem

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“…[56][57][58] The unique optical properties of nanomaterials can improve the sensitivity, specificity and accuracy of early tumor detection. Nanomaterials provide a Imaging depth and high resolution cannot be guaranteed simultaneously Strong targeting 52 Fluorescence imaging…”

Section: Nanomaterials Participate In the In Vitro Detection Of Bladd...mentioning

confidence: 99%

Application of nanotechnology in bladder cancer diagnosis and therapeutic drug delivery

Zhu

Weng

et al. 2023

J. Mater. Chem. B

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“…This approach yields high-contrast structural imaging, generated from the resultant acoustic waves through a photo-induced ultrasound imaging mechanism (115)(116)(117). Given its advantages of nonionizing radiation, non-invasiveness, deep penetration, and low cost, PAI has shown intriguing potential in facilitating the diagnostic process across diverse disciplines (118,119). Wang et al (120) engineered multifunctional NBs (PSMAP/ICG NBs) loaded with indocyanine green (ICG), with a specific targeting affinity for PSMA.…”

Section: Ultrasoundmentioning

confidence: 99%

Unleashing novel horizons in advanced prostate cancer treatment: investigating the potential of prostate specific membrane antigen-targeted nanomedicine-based combination therapy

He,

Cao,

Chi

et al. 2023

Front. Immunol.

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Prostate cancer (PCa) is a prevalent malignancy with increasing incidence in middle-aged and older men. Despite various treatment options, advanced metastatic PCa remains challenging with poor prognosis and limited effective therapies. Nanomedicine, with its targeted drug delivery capabilities, has emerged as a promising approach to enhance treatment efficacy and reduce adverse effects. Prostate-specific membrane antigen (PSMA) stands as one of the most distinctive and highly selective biomarkers for PCa, exhibiting robust expression in PCa cells. In this review, we explore the applications of PSMA-targeted nanomedicines in advanced PCa management. Our primary objective is to bridge the gap between cutting-edge nanomedicine research and clinical practice, making it accessible to the medical community. We discuss mainstream treatment strategies for advanced PCa, including chemotherapy, radiotherapy, and immunotherapy, in the context of PSMA-targeted nanomedicines. Additionally, we elucidate novel treatment concepts such as photodynamic and photothermal therapies, along with nano-theragnostics. We present the content in a clear and accessible manner, appealing to general physicians, including those with limited backgrounds in biochemistry and bioengineering. The review emphasizes the potential benefits of PSMA-targeted nanomedicines in enhancing treatment efficiency and improving patient outcomes. While the use of PSMA-targeted nano-drug delivery has demonstrated promising results, further investigation is required to comprehend the precise mechanisms of action, pharmacotoxicity, and long-term outcomes. By meticulous optimization of the combination of nanomedicines and PSMA ligands, a novel horizon of PSMA-targeted nanomedicine-based combination therapy could bring renewed hope for patients with advanced PCa.

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Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Cited by 19 publications

References 55 publications

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy

Application of nanotechnology in bladder cancer diagnosis and therapeutic drug delivery

Unleashing novel horizons in advanced prostate cancer treatment: investigating the potential of prostate specific membrane antigen-targeted nanomedicine-based combination therapy

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