Early Diagnosis of Cardiotoxicity in Patients Undergoing Chemotherapy for Acute Lymphoblastic Leukemia

Militaru, Anda; Zus, Sebastian; Cîmpean, Anca Maria; Iurciuc, Stela; Matusz, Petru; Iurciuc, Mircea; Lighezan, Daniel; Militaru, Marius

doi:10.21873/anticanres.13467

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…In this study, acute lymphoid leukemia high-risk patients presented cardiotoxicity with 150 mg/m 2 anthracycline cumulative doses at a median of 99 days. This lower frequency is similar to that reported by Militaru et al 's prospective study, which found an LVEF drop below 50% in 28.5% of children with acute lymphoid leukemia at three months of treatment 22 . It is not clear why the difference in the incidence of this condition with a similar evaluation period.…”

Section: Discussionsupporting

confidence: 91%

Early-onset Cardiotoxicity assessment related to anthracycline in children with leukemia. A Prospective Study

Ballesteros

Lobo²,

Valencia

et al. 2021

Colomb Med

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Background: Acute leukemias are the most frequent malignancies in children. Advances in treatment have improved the overall survival to 80%. Almost 10% of children with cancer develop clinical cardiac toxicity. Total anthracycline cumulative dose is a risk factor for early-onset cardiotoxicity. Objective: To describe the incidence of early-onset cardiotoxicity in children with acute leukemia treated with chemotherapy. Methods: A prospective descriptive study of patients >1 y and <18 years diagnosed with acute leukemia. Assessed with electrocardiogram, echocardiography, and blood biomarkers at diagnosis and during the follow-up. Results: 94 patients with acute lymphoblastic leukemia and 18 with acute myeloid leukemia were included. 20 patients (17.9%) developed early-onset cardiotoxicity. Statistically significant data was seen after anthracycline dose >150 mg/m2, between the first echocardiographic evaluation and posterior analyses in the left ventricular fraction ejection with Teicholz p 0.05, Simpson p 0.018 and GLS p 0.004. In this study, there was no relation between blood biomarkers and cardiotoxicity. Conclusions: Cancer therapeutic-related cardiac dysfunction is related to anthracycline cumulative dose. In this study, echocardiographic follow-up was useful to predict risk factors for early cardiac dysfunction.

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Section: Discussionsupporting

confidence: 91%

Early-onset Cardiotoxicity assessment related to anthracycline in children with leukemia. A Prospective Study

Ballesteros

Lobo²,

Valencia

et al. 2021

Colomb Med

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“…In contrast, a study carried out on 48 patients with DM-2 evidenced reduced values of ABI in half of them, with the prevalence of PAD being approximately 56.25% in patients with DM-2 [ 56 ]. The assessment of IMT and ABI as parameters of vascular remodeling were also analyzed in connection with other diseases, even with some specific therapies [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Militaru,

Lighezan,

Tudoran

et al. 2024

Biomedicines

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(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the association of DM-2 and AF favors a precocious onset of CD. (2) Methods: This study was conducted on 160 patients, featuring 50 with DM-2, 54 with DM-2 and AF, and 56 subjects without DM-2 and AF, all evaluated clinically and with five neuropsychiatric scales. (3) Results: The Mini-Mental-State-Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Score (ADL), Instrumental Activities of Daily Living Score (IADL), and Geriatric Depression Scale (GDS-15) were significantly altered in patients with DM-2 and AF in comparison to patients without these diseases. The logistic regression model indicated that, in patients with DM-2 and AF, an increase of one year in age is associated with a 7.3% augmentation of the risk of a precocious onset of CD (MMSE < 27). (4) Conclusions: CD is more frequent in patients with DM-2, especially when associated with AF, versus those without DM-2 and AF. Our findings suggest that an older age and associated dyslipidemia represent risk factors for CD in patients with DM-2.

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“…The health education paths for patients with chemotherapy were developed by the medical staff of the department, including disease cognition, medication management, diet management, and psychological nursing, and education was carried out through distribution of health promotion manuals and centralized or individual oral education. The patients also received monitoring of the vital signs, basic drug nursing and life nursing, and appropriate treatment of complications [ 12 – 14 ].…”

Section: Methodsmentioning

confidence: 99%

Application of High-Quality Nursing Intervention Based on Humanistic Care Combined with the Project Teaching Method in Patients with Acute Leukemia Undergoing Chemotherapy

Wang

2022

Journal of Healthcare Engineering

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Chemotherapy, the main treatment method of AL, can produce varying degrees of toxic and side effects on patients while killing tumor cells, resulting in decreased immune function of patients. We aim to explore the application effect of high-quality nursing intervention based on humanistic care combined with the project teaching method on patients with acute leukemia (AL) undergoing chemotherapy and its effect on their psychological state and satisfaction. 114 AL patients undergoing chemotherapy in the Department of Hematology of our hospital from July 2018 to July 2020 were chosen as the research objects and equally randomized into the experimental group (EG) and control group (CG). CG received routine nursing during chemotherapy, while EG received high-quality nursing intervention based on humanistic care combined with the project teaching method. Hospital Anxiety and Depression Scale (HAD) was adopted to evaluate the psychological state of patients in both groups after intervention, and the self-made nursing satisfaction questionnaire in our hospital was applied to evaluate the clinical nursing satisfaction. The HAD-A and HAD-D scores in the CG ( P < 0.001 ) were significantly higher than the HAD-A and HAD-D scores in the EG after intervention. The scores of various coping styles in the EG after intervention were better than those in the CG ( P < 0.05 ). Compared with the CG, the total nursing satisfaction after intervention was remarkably higher in the EG ( P < 0.001 ), while the total incidence of adverse reactions during intervention was notably lower ( P < 0.05 ). High-quality nursing intervention based on humanistic care combined with the project teaching method for AL patients undergoing chemotherapy can effectively relieve negative emotions, improve clinical nursing satisfaction, and reduce adverse reactions during chemotherapy.

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Early Diagnosis of Cardiotoxicity in Patients Undergoing Chemotherapy for Acute Lymphoblastic Leukemia

Cited by 7 publications

References 24 publications

Early-onset Cardiotoxicity assessment related to anthracycline in children with leukemia. A Prospective Study

Early-onset Cardiotoxicity assessment related to anthracycline in children with leukemia. A Prospective Study

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Application of High-Quality Nursing Intervention Based on Humanistic Care Combined with the Project Teaching Method in Patients with Acute Leukemia Undergoing Chemotherapy

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