Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application

Tascón, Javier; Prieto, Marta; Casanova, Alfredo G.; Sanz, Francisco; Mezquita, Miguel Hernández; Ferrero, Miguel Barrueco; Gómez‐Marcos, Manuel A.; Vicente-Vicente, Laura; Morales, Ana Isabel

doi:10.3390/jpm12071032

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Furthermore, smoking has an impact on CKD progression in patients [ 77 , 78 ], especially diagnosed with renal deterioration [ 79 ]. High glomerular filtration rate and greater prevalence of proteinuria in smokers suggests a hyperfiltration mechanism.…”

Section: Factors That May Be Deeply Related To Kidney Agingmentioning

confidence: 99%

Structural and Functional Changes in Aging Kidneys

Dybiec

Szlagor

Młynarska

et al. 2022

IJMS

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The renal condition is one of the crucial predictors of longevity; therefore, early diagnosis of any dysfunction plays an important role. Kidneys are highly susceptible to the aging process. Unfavorable conditions may lead to a significant disturbance of the body’s homeostasis. Apart from physiological changes, there are some conditions such as hypertension, diabetes or obesity which contribute to the acceleration of the aging process. A determination of macroscopic and microscopic changes is essential for assessing the progression of aging. With age, we observe a decrease in the volume of renal parenchyma and an increase in adipose tissue in the renal sinuses. Senescence may also be manifested by the roughness of the kidney surface or simple renal cysts. The main microscopic changes are a thickening of the glomerular basement membrane, nephrosclerosis, an accumulation of extracellular matrix, and mesangial widening. The principal aspect of stopping unfavorable changes is to maintain health. Studies have shown many useful ways to mitigate renal aging. This review is focused especially on medications such as renin-angiotensin-aldosterone system blockers or resveratrol, but even eating habits and lifestyle.

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Section: Factors That May Be Deeply Related To Kidney Agingmentioning

confidence: 99%

Structural and Functional Changes in Aging Kidneys

Dybiec

Szlagor

Młynarska

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…Tascón et al's (2022) study confirmed the effect of smoking on urinary albumin/protein excretion in persons from the general population with known normal renal functions also concluded that the albuminuria excretion rate was in correlation with the number of daily cigarettes smoking (measured as cotinine excretion). 19 …”

Section: Discussionmentioning

confidence: 99%

The Influence of Smoking on Renal Functions Among Apparently Healthy Smokers

Eid

Moazen

Elhussini

et al. 2022

JMDH

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Background Cigarette smoking is an important modifiable risk factor in kidney disease progression. Although long-term smoking has been associated with chronic kidney disease (CKD), its effect on kidney function in early stages has not been clarified. Objective To detect the early effects of smoking either active or passive on kidney functions. Methodology The current study was comparative cross sectional study conducted on 280 participants, 140 were non‑smokers and 140 were smokers (70 passive smokers and 70 active smokers). The two groups were comparable in terms of all parameters. We investigated the possible effects of smoking on kidney functions using both serum kidney function tests especially; serum urea, serum creatinine, serum cotinine levels and detection of albumin in urine. Smoking history, full Laboratory investigations, Ventilatory function test including (FEV1/FVC, FEV1, FEF 25–75%, VC and FVC) were done. Results Serum urea, serum creatinine, serum cotinine levels and urinary albumin were statistically significant higher in smokers group in comparison to nonsmokers, also the serum cotinine levels and urinary albumin were statistically significant in active smokers in comparison to passive smokers. There were positive correlations between the level of urinary albumin and pack/year (r = 0.9, p<0.05), smoking index (r = 0.9, p<0.05), smoking duration (r = 0.4, p<0.05), and serum cotinine (r = 0.6, p<0.050) with good statistical significance. The most significant predictive risk factors of microalbuminuria among smokers group in descending orders were active smoking, passive smoking, age and serum cotinine level. Conclusion Both active and passive smoking, especially among heavy smokers, is a significant risk factor for microalbuminuria. This finding increase the importance of early cessation of smoking in order to minimize early renal affection among healthy smokers that may not be discovered by routine renal function tests.

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“…Lifestyle choices and habits have a substantial influence on the development of CKD. The paper "Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application" accentuates a direct relationship between smoking and early subclinical kidney damage [7]. Significantly, the study has identified a panel of biomarkers capable of detecting this condition, including Neutrophil gelatinase-associated lipocalin, Kidney injury molecule-1, N-acetyl-beta-D-glucosaminidase, Transferrin, and Ganglioside-activating protein GM2.…”

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confidence: 99%