2008
DOI: 10.1159/000113417
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Early Discriminatory Diagnosis of Dementia with Lewy Bodies

Abstract: Background: The clinical diagnostic criteria for dementia with Lewy bodies (DLB) have a low sensitivity, and there are no generally accepted biomarkers to distinguish DLB from other dementias. Our aim was to identify biomarkers that may differentiate DLB from Alzheimer’s disease (AD). Method: We performed a systematic literature search for studies of EEG, imaging techniques and genetic and CSF markers that provide sensitivity and specificity in the identification of DLB. Results: The best evidence was for scin… Show more

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Cited by 42 publications
(23 citation statements)
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References 180 publications
(103 reference statements)
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“…An early literature review highlighted preservation of the hippocampus and medial temporal lobe volume (see figure 3) in DLB in comparison with AD on structural MRI; however, these differences were on a group level between patients with DLB and AD, and sensitivity was found to be a low 40% 32…”
Section: Methodsmentioning
confidence: 99%
“…An early literature review highlighted preservation of the hippocampus and medial temporal lobe volume (see figure 3) in DLB in comparison with AD on structural MRI; however, these differences were on a group level between patients with DLB and AD, and sensitivity was found to be a low 40% 32…”
Section: Methodsmentioning
confidence: 99%
“…DLB is considered to be the second most common form of neurodegenerative dementia after Alzheimer's disease (AD) 1. Consensus criteria for the clinical diagnosis of DLB were proposed2; however, the problem in diagnosis is the relatively low sensitivity of the criteria despite the high specificity 1 3. There is considerable overlap of clinical manifestations as well as neuropathology between DLB and AD patients, which could lead to an inaccurate antemortem diagnosis 3…”
Section: Introductionmentioning
confidence: 99%
“…at serine 231 or threonine 181) provided additional sensitivity and helped differentiating AD from the most problematic differential diagnoses, as dementia in the course of Parkinson's disease, frontal lobe dementia [17][18][19] and even proteiform diseases such as dementia with lewy bodies (DLB - [20]). …”
mentioning
confidence: 99%