Early effects of oestrogen treatment on lipogenesis de novo and on biosynthesis of triacylglycerol from fatty acids in male chick liver

Courtney, Sarah; Talbot, S.; Manning, Ray

doi:10.1016/0020-711x(88)90013-4

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Estrogen treatment has been found to increase fat content in the liver of male chicks (Courtney et al, 1988) and immature male turkeys (Dashti et al, 1983). High energy consumption was also shown to increase the relative weights of abdominal fat (Deaton and Lott, 1985; Jones and Wiseman, 1985).…”

Section: Resultsmentioning

confidence: 99%

“…Considering the prior experiment, the acceleration of fatty acid and triacylglycerol synthesis in estrogenized hens in the present study may be a result of increase of hepatic triacylglycerol content. Indeed, intramuscular 17-β estradiol administration induced fatty acid synthesis and triacylglycerol synthesis, and increased enzyme activity (Courtney et al, 1988). …”

Section: Resultsmentioning

confidence: 99%

“…Consistent with the results of the present study, activities of ACC and FAS mRNA were increased in estrogen-injected male chicks (Manning et al, 1989). Similarly, lipid metabolism was elevated in hens intramuscularly treated with 17-β-estrogen (Courtney et al, 1988). …”

Section: Resultsmentioning

confidence: 99%

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Nutritional and Hormonal Induction of Fatty Liver Syndrome and Effects of Dietary Lipotropic Factors in Egg-type Male Chicks

Choi¹,

Ahn²,

Lee³

et al. 2012

Asian Australas. J. Anim. Sci

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This experiment was conducted with male chicks to investigate the influence of hormones and nutrients on the development of fatty liver syndrome (FLS) as well as the effects of dietary lipotropic factors on hepatic fat accumulation and lipogenic enzyme gene expression. A total of two-hundred sixteen 4-wk-old Hy-Line male chicks were divided into six groups and fed an experimental diet (T1, low-energy diet with low levels of lipotropic factors; T2, high-energy diet with low levels of lipotropic factors; T3 and T5, low-energy diet with high levels of lipotropic factors; T4 and T6, high-energy diet with high levels of lipotropic factors) for six weeks. The chicks in T5 and T6 groups were treated with intramuscular injections of estradiol benzoate for three days prior to biopsy and clinical analysis of FLS. Chicks treated with estrogen had significantly greater liver weights than untreated chicks. The abdominal fat contents were increased in chicks consuming high-energy diets as compared to those consuming low-energy diets. Treatment with estrogen significantly increased the concentrations of serum cholesterol, triacylglycerol and phospholipid (p<0.05). The hepatic triacylglycerol levels were tenfold higher in the estrogen treated chicks than in the untreated chicks. There were no significant differences in malondialdehyde levels between the treatment groups. Estrogen treatment dramatically increased the levels of fatty acid synthetase, acetyl-CoA carboxylase and ApoB mRNA. The results indicated that treatment with exogenous estrogen in growing male chicks induced hepatic fat accumulation, which might be partially due to increased lipogenic enzyme gene expression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutritional and Hormonal Induction of Fatty Liver Syndrome and Effects of Dietary Lipotropic Factors in Egg-type Male Chicks

Choi¹,

Ahn²,

Lee³

et al. 2012

Asian Australas. J. Anim. Sci

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“…Modification of the egg production period by changing the lighting program improves goose egg production rate and changes serum hormone concentrations (Hsu et al, 1990a,b;Lai et al, 1996). Estrogen induces the expression of lipogenic and genes related to egg formation in the liver of the layers (Kudzma et al, 1975;Dashti et al, 1983;Courtney et al, 1988). We have previously demonstrated that estrogen injection increased the expression of very low density apolipoprotein II (apoVLDL II), vitellogenin I, and G-protein-γ5 subunit in prelay geese (Ding et al, 2007).…”

Section: Introductionmentioning

confidence: 93%

Abundantly expressed hepatic genes and their differential expression in liver of prelaying and laying geese

et al. 2009

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Geese have a short egg-laying period and a low egg production rate. To induce and maintain egg laying, genes related to generating hepatic lipid for yolk deposition should be adequately expressed. Liver mRNA from 6 laying geese was extracted and used for construction of a full-length enriched cDNA library. About 2,400 clones containing gene sequences were determined and National Center for Biotechnology Information Gallus gallus Gene Index databases were used to compare and analyze these sequences. Ten highly expressed genes were selected to determine the differential expression between laying and prelay goose liver. Tissue distribution data showed that very low density apolipoprotein II, liver type fatty acid binding protein, vitellogenin I, and vitellogenin II transcripts were specifically expressed in the liver of laying geese. Ovoinhibitor, preproalbumin, alpha-2-hs-glycoprotein, and vitamin D binding protein mRNA were highly expressed in the liver and to a lesser extent in other tissues. Ovotransferrin mRNA was expressed in liver, ovary, oviduct, shell gland, brain, and adipose tissues. The concentration of transthyretin mRNA was high in the liver and brain. The mRNA concentrations of liver type fatty acid binding protein, alpha-2-hs-glycoprotein, and transthyretin in the livers of laying and prelay geese were not different. The concentrations of hepatic ovotransferrin, ovoinhibitor, preproalbumin, very low density apolipoprotein II, vitellogenin I, vitellogenin II, and vitamin D binding protein mRNA were higher in the liver of laying geese than in prelay geese, suggesting that these genes may be involved in laying function or lipid metabolism related to egg formation.

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“…Estrogen signaling is important in both males and females in the regulation of lipogenesis, demonstrated by using animal models and human studies. Specifically, estrogens regulate the activity and expression of lipogenic genes to directly inhibit lipogenesis in several animal species [ 37 , 38 ]. Liver enzymes may also be regulated by circulating estrogen levels.…”

Section: The Role Of Estrogens In Regulating Liver Energy Homeostamentioning

confidence: 99%

Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis

Shen

Shi

2015

International Journal of Endocrinology

183

127

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The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological studies show sex difference in the prevalence in fatty liver disease and suggest that sex hormones may play vital roles in regulating hepatic steatosis. In this review, we summarize current literature and discuss the role of estrogens and androgens and the mechanisms through which estrogen receptors and androgen receptors regulate lipid and glucose metabolism in the liver. In females, estradiol regulates liver metabolism via estrogen receptors by decreasing lipogenesis, gluconeogenesis, and fatty acid uptake, while enhancing lipolysis, cholesterol secretion, and glucose catabolism. In males, testosterone works via androgen receptors to increase insulin receptor expression and glycogen synthesis, decrease glucose uptake and lipogenesis, and promote cholesterol storage in the liver. These recent integrated concepts suggest that sex hormone receptors could be potential promising targets for the prevention of hepatic steatosis.

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Early effects of oestrogen treatment on lipogenesis de novo and on biosynthesis of triacylglycerol from fatty acids in male chick liver

Cited by 11 publications

References 23 publications

Nutritional and Hormonal Induction of Fatty Liver Syndrome and Effects of Dietary Lipotropic Factors in Egg-type Male Chicks

Nutritional and Hormonal Induction of Fatty Liver Syndrome and Effects of Dietary Lipotropic Factors in Egg-type Male Chicks

Abundantly expressed hepatic genes and their differential expression in liver of prelaying and laying geese

Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis

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