Early elevation of S-100B protein in blood after cardiac surgery is not a predictor of ischemic cerebral injury

Mißler, U.; Orlowski, Nicola; Nötzold, A.; Dibbelt, L.; Steinmeier, Elke; Wiesmann, Martin

doi:10.1016/s0009-8981(02)00061-x

Cited by 48 publications

(34 citation statements)

References 25 publications

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“…Recent evidence suggests that extracerebral sources may also influence serum S100B (21 ), although usually in a minor way. Moreover, S100B production by the fetus could also be feasibly playing a role in our findings because concentrations of the protein are known to be quite high in cord blood compared with those found in adult serum (22,23 ).…”

Section: Clinical Chemistry 50 No 2 2004mentioning

confidence: 99%

Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case–Control Study

et al. 2004

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precision has been stated to be 11.6 mol/L (10 ). The imprecision (CV) for total bilirubin measurements on the Olympus analyzer ranged from 4.2% at a concentration of 123.1 mol/L to 2.8% at a concentration of 372.8 mol/L.The ability to measure bilirubin concentrations in newborns simply, rapidly, accurately, cost-effectively, and with minimal risk or discomfort has taken on increased importance in the current environment of managed care, capitation, litigation, and brief postpartum hospitalization. Measurement of bilirubin by various transcutaneous techniques has been reported from several studies with mixed results (5,(7)(8)(9)(10)(15)(16)(17)(18)(19). Race, as assessed by skin color score, did not have an effect on the performance of the BiliCheck method. In addition, other potential confounding factors, such as birth weight, gestational age, and postnatal age, did not affect the BiliCheck device.The results of our study may have been influenced by several factors. Freezing and storage of samples for HPLC analysis might have led to some degradation of bilirubin. However, the data shown in the Bland-Altman difference plots suggest that bilirubin degradation was not a significant factor. Other factors that might have influenced our results were the demographics of newborns evaluated in our study. All infants were Ͼ32 weeks of gestational age, none had undergone phototherapy, and all were Ͻ4 days of age. In addition, all transcutaneous measurements were performed in duplicate by a single individual, whereas singleton determinations by multiple caregivers would most likely be performed in routine practice.Currently, measurement of total bilirubin in serum or plasma of newborns is the standard of care for the assessment of neonatal jaundice. Our results indicate that the transcutaneous measurement of bilirubin is as accurate as bilirubin measured in plasma in a hospital laboratory when HPLC is used as the comparison method. In conclusion, measurement of bilirubin by the BiliCheck device offers an accurate, rapid, and noninvasive means of assessing plasma bilirubin concentrations in neonates.We thank Respironics (Marietta, GA) for supplying the reagents used in this study. We also acknowledge the cooperation of the newborn nursing staff at Pitt County Memorial Hospital.

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Section: Clinical Chemistry 50 No 2 2004mentioning

confidence: 99%

Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case–Control Study

et al. 2004

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“…Although S100B is the most promising marker, conflicting results for increased serum S100B concentrations after cardiac injury (11,12 ) indicate that the specificity of this protein is limited.…”

mentioning

confidence: 99%

Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility

Pelsers¹,

Hanhoff

Voort³

et al. 2004

Clinical Chemistry

109

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“…Because all assays for the quantification of S100B are only specific for the b-chain they must detect S100a (a-b) as well as b-b. In our opinion this is an important reason for the increase of S100B during and early after cardiac surgery [2]. The antibody used in our current study (S-2657, Sigma-Aldrich, Seelze, Germany) was tested for cross-reactivity with other calcium-binding molecules of the EF hand type but no positive results could be seen.…”

Section: A Replymentioning

confidence: 89%

A response to ‘Cerebral and extracerebral release of protein S100B in cardiac surgical patients’, Snyder‐Ramos SA, Gruhlke T, Bauer H, Bauer M, Luntz AP, Motsch J, Martin E, Vahl CF, Missler U, Wiesmann M and Bottiger BW, Anaesthesia 2004; 59: 344–9

Janigro

2004

Anaesthesia

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Early elevation of S-100B protein in blood after cardiac surgery is not a predictor of ischemic cerebral injury

Cited by 48 publications

References 25 publications

Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case–Control Study

Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case–Control Study

Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility

A response to ‘Cerebral and extracerebral release of protein S100B in cardiac surgical patients’, Snyder‐Ramos SA, Gruhlke T, Bauer H, Bauer M, Luntz AP, Motsch J, Martin E, Vahl CF, Missler U, Wiesmann M and Bottiger BW, Anaesthesia 2004; 59: 344–9

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