Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus

Cao, Wenzhi; Duan, Juan; Wang, Xueqin; Zhong, Xiaolin; Hu, Zhao‐Lan; Huang, Fang; Wang, Hongtao; Zhang, Juan; Li, Fang; Zhang, Jianyi; Luo, Xi; Li, Chang-Qi

doi:10.1016/j.bbr.2014.02.022

Cited by 97 publications

(43 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that stressinduced increase of proBDNF is not due to the increased Bdnf transcription but is likely because of the inhibition of proteolytic processing of proBDNF. Interestingly, a number of studies have shown that antidepressants facilitate the conversion of proBDNF to BDNF by upregulation of the proteolytic cleavage enzymes of proBDNF (Cao et al, 2014;Sartori et al, 2011;Segawa et al, 2013), supporting our hypothesis. Furthermore, chronic stress in the present study decreased both transcriptional and translational levels of TrkB in the neocortex and hippocampus of rats, consistent with the previous findings that TrkB mRNA expression is reduced in pituitary gland of rats exposed to immobilization stress (Givalois et al, 2001).…”

Section: Discussionsupporting

confidence: 87%

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

Bai

Ruan

Yang

et al. 2016

Neuropsychopharmacol

104

View full text Add to dashboard Cite

Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this study, using an unpredictable chronic mild stress (UCMS) paradigm we found that the protein levels of proBDNF were increased in the neocortex and hippocampus of stressed mice and this UCMS-induced upregulation of proBDNF was abolished by chronic administration of fluoxetine. We then established a rat model of UCMS and found that the expression of proBDNF/p75 NTR /sortilin was upregulated, whereas the expression of mature BDNF and TrkB was downregulated in both neocortex and hippocampus of chronically stressed rats. Finally, we found that the injection of anti-proBDNF antibody via intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) approaches into the UCMS rats significantly reversed the stress-induced depression-like behavior and restored the exploratory activity and spine growth. Although intramuscular injection of AAV-proBDNF did not exacerbate the UCMS-elicited rat mood-related behavioral or pathological abnormalities, i.c.v. injection of AAV-proBDNF increased the depression-like behavior in naive rats. Our findings suggest that proBDNF plays a role in the development of chronic stress-induced mood disturbances in rodents. Central (i.c.v.) or peripheral (i.p.) inhibition of proBDNF by injecting specific antiproBDNF antibodies may provide a novel therapeutic approach for the treatment of stress-related mood disorders.

show abstract

Section: Discussionsupporting

confidence: 87%

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

Bai

Ruan

Yang

et al. 2016

Neuropsychopharmacol

104

View full text Add to dashboard Cite

show abstract

“…BDNF is cleaved from proBDNF by different proteases and in response to stimulation (62, 63). Though proBDNF has been shown to have opposite effects of BDNF in learning and memory, and despite the plethora of information tying BDNF to motor function, many articles investigating motor function and BDNF ignore proBDNF.…”

Section: Discussionmentioning

confidence: 99%

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

Suire

Eitan

Shaffer

et al. 2017

Experimental Gerontology

View full text Add to dashboard Cite

Background Brain-derived neurotrophic factor (BDNF) is produced by cleavage of proBDNF, and BDNF and proBDNF may play antagonistic roles in nervous system development, learning, memory and neuronal stress resistance. BDNF and proBDNF are present in blood, but the origin and relative contributions of soluble and extracellular vesicle (EV)-associated levels are unknown. Methods In this study we used validated immunoassays to measure proBDNF and BDNF levels in plasma, total plasma EVs and a subpopulation of EVs enriched for neuronal origin (expressing the neuronal marker L1CAM) in 150 Baltimore Longitudinal Study of Aging participants with and without decline in walking speed (reflecting aging-associated motor decline). Results Levels of BDNF and proBDNF were highest in L1CAM+ EVs. Participants with walking speed decline had higher levels of proBDNF in L1CAM+ EVs compared to non-decliners, but no differences in proBDNF levels in plasma and total EV. Conclusions Our findings suggest that levels of proBDNF and BDNF in circulating L1CAM+ EVs might be used as biomarkers for conditions involving altered BDNF signaling.

show abstract

“…At involution, the action of pro-apoptotic molecules could be counterbalanced by the neurotrophins. Moreover, during this period, in sheep mammary glands, the concomitant expression of insulin-like growth factor binding protein 5 (IGFBP5) and the nuclear positivity of ERα (Colitti and Farinacci 2009;Colitti and Parillo 2013) has been also related to plasminogen activation (Stefanon et al 2002;Nǿrgaard et al 2008) or to matrix metalloproteinases (MMP9) (Khokha and Werb 2011) that regulated the cleavage of pro-neurotrophins to the mature form (Lee et al 2001;Cao et al 2014). It could be of interest to detect at involution the expression of p75-NTR that induces apoptosis when binds BDNF.…”

Section: Discussionmentioning

confidence: 99%

Expression of NGF, BDNF and their high-affinity receptors in ovine mammary glands during development and lactation

Colitti

2015

Histochem Cell Biol

View full text Add to dashboard Cite

Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus

Cited by 97 publications

References 35 publications

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

Expression of NGF, BDNF and their high-affinity receptors in ovine mammary glands during development and lactation

Contact Info

Product

Resources

About