Early environmental quality and life-course mental health effects: The Equal-Life project

Kamp, Irene van; Waye, Kerstin Persson; Gulliver, John; Bozzon, Alessandro; Psyllidis, Achilleas; Boshuizen, Hendriek C.; Selander, Jenny; Hazel, Peter van den; Brambilla, Marco; Foraster, María; Júlvez, Jordi; Klatte, Maria; Jeram, Sonja; Botteldooren, Dick; Ристовска, Гордана; Kaprio, Jaakko; Schreckenberg, Dirk; Hornikx, Maarten; Fels, Janina; Weber, Miriam; Braat-Eggen, Ella; Hartmann, Julia; Clark, Charlotte; Vrijkotte, Tanja G. M.; Brown, Lex; Bolte, Gabriele

doi:10.1097/ee9.0000000000000183

Cited by 21 publications

(12 citation statements)

References 35 publications

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“…In total, we curated 385 environmental exposures under the concept of the Equal-Life project 42 from multiple sources and group them into 12 domains. Air pollution exposures came from the annual average air quality of each observation station from the Finnish Meteorological Institute.…”

Section: Methodsmentioning

confidence: 99%

Systematic evaluation of the environmental effect on depressive symptoms in late adolescence and early adulthood: exposome-wide association study and twin modeling

Wang

Zellers

Whipp

et al. 2023

Preprint

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The exposome represents the totality of environmental effects, but systematic evaluation between it and depressive symptoms is scant. We sought to comprehensively identify the association of the exposome with depressive symptoms in late adolescence and early adulthood and determine genetic and environmental covariances between them. Based on the population-based FinnTwin12 cohort (3025 participants in young adulthood and 4127 at age 17), the exposome-wide association study (ExWAS) design was used to identify significant exposures from 12 domains. Bivariate Cholesky twin models were fitted to an exposome score and depressive symptoms. In ExWASes, 29 and 46 exposures were significantly associated with depressive symptoms in young adulthood and at age 17, respectively, and family-related exposures were the most influential. Twin models indicated considerable genetic and environmental covariances between the exposome score and depressive symptoms. The findings underscore the systematic approach of the exposome and the consideration of relevant genetic effects.

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Section: Methodsmentioning

confidence: 99%

Systematic evaluation of the environmental effect on depressive symptoms in late adolescence and early adulthood: exposome-wide association study and twin modeling

Wang

Zellers

Whipp

et al. 2023

Preprint

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“…We gratefully acknowledge the contribution of the early environmental quality and life-course mental health effects (Equal-Life) project team and the laboratory assistance of Mirka Tikkanen. Equal-Life is part of the European Human Exposome Network comprehensively described by van Kamp et al [ 55 ].…”

Section: Acknowledgmentsmentioning

confidence: 99%

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

et al. 2023

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Adolescence is often a challenging time in which psychiatric issues have a strong connection to mental health disorders later in life. The early identification of the problems can reduce the burden of disease. To date, the effective identification of adolescents at risk of developing mental health problems remains understudied. Altogether, the interaction between circulating cell-free mtDNA (ccf-mtDNA) and inflammatory cytokines in adolescents is insufficiently understood regarding experienced mental health difficulties. Our study selected the participants based on the Strength and Difficulty Questionnaire (SDQ) score using the cut-off points of 3 and 18 for the low and the high score groups, respectively. The answers of the SDQ at the age of 12.2–15.7 years contributed to the investigation of (i) whether ccf-mtDNA units are associated with cytokines, and (ii) if an interaction model for predicting risk of mental health issues is observed. We discovered a sex-specific correlation between the screened markers associated with mental health problems in the low and high SDQ score groups among the male participants and in the low SDQ score group among the female participants. The mitochondrial MT-ND4 and MT-CO1 genes correlated significantly with interleukin-12p70 (IL-12p70) in males and with monocyte chemoattractant protein-1 (MCP-1) in females. Due to the nature of the explorative study, the studied markers alone did not indicate statistical significance for the prediction of mental health problems. Our analysis provided new insight into potential plasma-based biomarkers to predict mental health issues.

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“…The domain of the external exposome comprised a total of 65 exposures derived from two sources: Equal-life project (van Kamp et al, 2022) enrichment datasets and Statistics Finland. We used twin's geocodes in 2005-2006 to merge the exposures, which were extensively described elsewhere (Wang et al, 2023).…”

Section: External Exposomementioning

confidence: 99%

“…The specific external exposome includes specific environmental factors such as diet, occupational exposures and lifestyle factors (Debord et al, 2017). In the context of this paper, we distinguish between the internal and external exposome, the latter including social and physical exposomes (van Kamp et al, 2022) but not lifestyle. Finally, environmental imprints on omic profiles are commonly classified as part of the internal exposome, as omics data has been shown to be highly sensitive to the environment, and genetic factors only explain part of their variance.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

Drouard,

Wang,

Heikkinen

et al. 2023

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Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins’ exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.

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Early environmental quality and life-course mental health effects: The Equal-Life project

Cited by 21 publications

References 35 publications

Systematic evaluation of the environmental effect on depressive symptoms in late adolescence and early adulthood: exposome-wide association study and twin modeling

Systematic evaluation of the environmental effect on depressive symptoms in late adolescence and early adulthood: exposome-wide association study and twin modeling

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

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